Browsing Harvard Medical School by Keyword "nitric oxide"
Now showing items 1-18 of 18
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Association of Expired Nitric Oxide with Occupational Particulate Exposure
(2003)Particulate air pollution has been associated with adverse respiratory health effects. This study assessed the utility of expired nitric oxide to detect acute airway responses to metal-containing fine particulates. Using ... -
Evaluation of Endoscopic Vein Extraction on Structural and Functional Viability of Saphenous Vein Endothelium
(BioMed Central, 2011)Objectives: Endothelial injury during harvest influences graft patency post CABG. We have previously shown that endoscopic harvest causes structural and functional damage to the saphenous vein (SV) endothelium. However, ... -
Female resistance to pneumonia identifies lung macrophage nitric oxide synthase-3 as a therapeutic target
(eLife Sciences Publications, Ltd, 2014)To identify new approaches to enhance innate immunity to bacterial pneumonia, we investigated the natural experiment of gender differences in resistance to infections. Female and estrogen-treated male mice show greater ... -
Functional role of the soluble guanylyl cyclase α1 subunit in vascular smooth muscle relaxation
(Oxford University Press (OUP), 2007)Objective: Soluble guanylyl cyclase (sGC), the predominant receptor for nitric oxide (NO), exists in 2 active isoforms (α2β1 and α1β1). In vascular tissue sGCα1β1 is believed to be the most important. The aim of our study ... -
Gender-specific hypertension and responsiveness to nitric oxide in sGCa1 knockout mice
(Oxford University Press (OUP), 2008)Aim: The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the α1β1 isoform of soluble guanylate cyclase (sGC). Because available sGC inhibitors are neither enzyme- nor ... -
Heme deficiency of soluble guanylate cyclase induces gastroparesis
(Wiley-Blackwell, 2013)Background: Soluble guanylate cyclase (sGC) is the principal target of nitric oxide (NO) to control gastrointestinal motility. The consequence on nitrergic signaling and gut motility of inducing a heme-free status of sGC, ... -
In vitro and in vivo studies on the importance of the soluble guanylyl cyclase a1 subunit in penile erection
(Springer Nature, 2010)Purpose: Soluble guanylyl cyclase (sGC), which plays a pivotal role in penile erection, is a heterodimer build up by an α and a β subunit. For both subunits two isoforms have been characterized, but only the sGCα1β1 and ... -
Inhibition of VEGF or TGF- Signaling Activates Endothelium and Increases Leukocyte Rolling
(Ovid Technologies (Wolters Kluwer Health), 2009)Objective Motivated by the central roles that VEGF and TGF-β play in the assembly and maintenance of the vasculature, we examined the impact of systemic VEGF or TGF-β signal inhibition on endothelial activation as ... -
Involvement of soluble guanylate cyclase α1 and α2, and SKCa channels in NANC relaxation of mouse distal colon
(Elsevier BV, 2008)In distal colon, both nitric oxide (NO) and ATP are involved in non-adrenergic non-cholinergic (NANC) inhibitory neurotransmission. The role of the soluble guanylate cyclase (sGC) isoforms α1β1 and α2β1, and of the small ... -
New insights into the role of soluble guanylate cyclase in blood pressure regulation
(Ovid Technologies (Wolters Kluwer Health), 2014)Purpose of review: Nitric oxide (NO) – soluble guanylate cyclase (sGC)-dependent signaling mechanisms have a profound effect on the regulation of blood pressure. In this review, we will discuss recent findings in the field ... -
Nitric oxide and mitochondria in metabolic syndrome
(Frontiers Media S.A., 2015)Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in ... -
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines
(American Society for Clinical Investigation, 1995)To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects on the inducible expression ... -
Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice*
(Ovid Technologies (Wolters Kluwer Health), 2009)Objectives: Despite advances in resuscitation methods, survival after out-of-hospital cardiac arrest remains low, at least in part, due to postcardiac arrest circulatory and neurologic failure. To elucidate the role of ... -
Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma
(Frontiers Media S.A., 2014)Glaucoma is a progressive optic neuropathy characterized by visual field defects that ultimately lead to irreversible blindness (Alward, 2000; Anderson et al., 2006). By the year 2020, an estimated 80 million people will ... -
The Role of Shear-Induced Transforming Growth Factor-? Signaling in the EndotheliumSignificance
(Ovid Technologies (Wolters Kluwer Health), 2013)Objective Vascular endothelial cells (ECs) are continuously exposed to blood flow that contributes to the maintenance of vessel structure and function; however, the effect of hemodynamic forces on transforming growth ... -
Role of the soluble guanylyl cyclase α1-subunit in mice corpus cavernosum smooth muscle relaxation
(Springer Nature, 2007)Soluble guanylyl cyclase (sGC) is the major effector molecule for nitric oxide (NO) and as such an interesting therapeutic target for the treatment of erectile dysfunction. To assess the functional importance of the sGCα1β1 ... -
sGCα1 Mediates the Negative Inotropic Effects of NO in Cardiac Myocytes Independent of Changes in Calcium Handling
(American Physiological Society, 2011)In the heart, nitric oxide (NO) modulates contractile function; however, the mechanisms responsible for this effect are incompletely understood. NO can elicit effects via a variety of mechanisms including S-nitrosylation ... -
Soluble Guanylate Cyclase-alpha1 Deficiency Selectively Inhibits the Pulmonary Vasodilator Response to Nitric Oxide and Increases the Pulmonary Vascular Remodeling Response to Chronic Hypoxia
(Ovid Technologies (Wolters Kluwer Health), 2007)BACKGROUND: Nitric oxide (NO) activates soluble guanylate cyclase (sGC), a heterodimer composed of alpha- and beta-subunits, to produce cGMP. NO reduces pulmonary vascular remodeling, but the role of sGC in vascular responses ...