Browsing Harvard Medical School by Keyword "acute lymphoblastic leukemia"

Now showing items 1-2 of 2

    • Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction 

      Ge, Zheng; Gu, Yan; Xiao, Lichan; Han, Qi; Li, Jianyong; Chen, Baoan; Yu, James; Kawasawa, Yuka Imamura; Payne, Kimberly J.; Dovat, Sinisa; Song, Chunhua (Impact Journals LLC, 2016)
      Acute lymphoblastic leukemia (ALL) remains the leading cause of cancer-related death in children and young adults. Compared to ALL in children, adult ALL has a much lower cure rate. Therefore, it is important to understand ...

    • Survey of Activated FLT3 Signaling in Leukemia 

      Gu, Ting-lei; Nardone, Julie; Loriaux, Marc; Tucker, Meghan; Kornhauser, Jon; Ren, Jianmin; MacNeill, Joan; Druker, Brian J.; Heinrich, Michael C.; Rush, John; Polakiewicz, Roberto D.; Villén, Judit; Gygi, Steven P.; Beausoleil, Sean A; Wang, Yi (Public Library of Science, 2011)
      Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which ...