Browsing Harvard Medical School by Keyword "brain"
Now showing items 1-20 of 21
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Age at Developmental Cortical Injury Differentially Alters Corpus Callosum Volume in the Rat
(BioMed Central, 2007)Background: Freezing lesions to developing rat cortex induced between postnatal day (P) one and three (P1 – 3) lead to malformations similar to human microgyria, and further correspond to reductions in brain weight and ... -
Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei
(Proceedings of the National Academy of Sciences, 2001)Microarray technology represents a potentially powerful method for identifying cell type- and regionally restricted genes expressed in the brain. Here we have combined a microarray analysis of differential gene expression ... -
Barriers, Benefits, and Beliefs of Brain Training Smartphone Apps: An Internet Survey of Younger US Consumers
(Frontiers Media SA, 2016)Background: While clinical evidence for the efficacy of brain training remains in question, numerous smartphone applications (apps) already offer brain training directly to consumers. Little is known about why consumers ... -
Brain temperature and its fundamental properties: a review for clinical neuroscientists
(Frontiers Media S.A., 2014)Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although ... -
Cognitive Enhancement Therapy Improves Frontolimbic Regulation of Emotion in Alcohol and/or Cannabis Misusing Schizophrenia: A Preliminary Study
(Frontiers Media S.A., 2016)Individuals with schizophrenia who misuse substances are burdened with impairments in emotion regulation. Cognitive enhancement therapy (CET) may address these problems by enhancing prefrontal brain function. A small sample ... -
The Contribution of Cortical Lesions to a Composite MRI Scale of Disease Severity in Multiple Sclerosis
(Frontiers Media S.A., 2016)Objective: To test a new version of the Magnetic Resonance Disease Severity Scale (v.3 = MRDSS3) for multiple sclerosis (MS), incorporating cortical gray matter lesions (CLs) from 3T magnetic resonance imaging (MRI). ... -
Diffusion tensor and volumetric magnetic resonance imaging using an MR-compatible hand-induced robotic device suggests training-induced neuroplasticity in patients with chronic stroke
(D.A. Spandidos, 2013)Stroke is the third leading cause of mortality and a frequent cause of long-term adult impairment. Improved strategies to enhance motor function in individuals with chronic disability from stroke are thus required. Post-stroke ... -
The E-NTPDase Family of Ectonucleotidases: Structure Function Relationships and Pathophysiological Significance
(Springer Netherlands, 2006)Ectonucleotidases are ectoenzymes that hydrolyze extracellular nucleotides to the respective nucleosides. Within the past decade, ectonucleotidases belonging to several enzyme families have been discovered, cloned and ... -
Evidence for Acquired Pregenual Anterior Cingulate Gray Matter Loss from a Twin Study of Combat-Related Posttraumatic Stress Disorder
(Elsevier BV, 2008)Background Controversy exists over the nature and origin of reduced regional brain volumes in posttraumatic stress disorder (PTSD). At issue is whether these reductions represent preexisting vulnerability factors for ... -
An expanded composite scale of MRI-defined disease severity in multiple sclerosis: MRDSS2
(Lippincott Williams & Wilkins, 2014)The objective of this study was to test a new version of the Magnetic Resonance Disease Severity Scale (MRDSS2), incorporating cerebral gray matter (GM) and spinal cord involvement from 3 T MRI, in modeling the relationship ... -
Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots
(Bentham Open, 2008)We monitored brain activation after chronic stroke by combining functional magnetic resonance imaging (fMRI) with a novel MR-compatible, hand-induced, robotic device (MR_CHIROD). We evaluated 60 fMRI datasets on a 3 T MR ... -
Histone Deacetylase Inhibitor MS-275 Exhibits Poor Brain Penetration: Pharmacokinetic Studies of [ 11 C]MS-275 using Positron Emission Tomography
(American Chemical Society (ACS), 2010)MS-275 (entinostat) is a histone deacetylase (HDAC) inhibitor currently in clinical trials for the treatment of several types of cancer. Recent reports have noted that MS-275 can cross the blood−brain barrier (BBB) and ... -
Is There a Role for Treating Inflammation in Moyamoya Disease?: A Review of Histopathology, Genetics, and Signaling Cascades
(Frontiers Media S.A., 2013)Moyamoya disease is a slowly progressing steno-occlusive condition affecting the cerebrovasculature. Affecting the terminal internal carotid arteries (ICA) and there branches, bilaterally, a resulting in a fine vascular ... -
An MRI study of spatial probability brain map differences between first-episode schizophrenia and normal controls
(Elsevier BV, 2004)We created a spatial probability atlas of schizophrenia to provide information about the neuroanatomic variability of brain regions of patients with the disorder. Probability maps of 16 regions of interest (ROIs) were ... -
Nonthermal ablation of deep brain targets: A simulation study on a large animal model
(American Association of Physicists in Medicine, 2016)Purpose: Thermal ablation with transcranial MRI-guided focused ultrasound (FUS) is currently limited to central brain targets because of heating and other beam effects caused by the presence of the skull. Recently, it was ... -
Quality assessment and control of tissue specific RNA-seq libraries of Drosophila transgenic RNAi models
(Frontiers Media S.A., 2014)RNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce ... -
Resolving rates of mutation in the brain using single-neuron genomics
(eLife Sciences Publications, Ltd, 2016)Whether somatic mutations contribute functional diversity to brain cells is a long-standing question. Single-neuron genomics enables direct measurement of somatic mutation rates in human brain and promises to answer this ... -
Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases
(Libertas Academica, 2015)The nuclear hormone receptor (NHR) superfamily is composed of a wide range of receptors involved in a myriad of important biological processes, including development, growth, metabolism, and maintenance. Regulation of such ... -
Simultaneous EEG Monitoring During Transcranial Direct Current Stimulation
(MyJove Corporation, 2013)Transcranial direct current stimulation (tDCS) is a technique that delivers weak electric currents through the scalp. This constant electric current induces shifts in neuronal membrane excitability, resulting in secondary ... -
Systems approach to the study of brain damage in the very preterm newborn
(Frontiers Media S.A., 2015)Background:: A systems approach to the study of brain damage in very preterm newborns has been lacking. Methods:: In this perspective piece, we offer encephalopathy of prematurity as an example of the complexity and ...