Browsing Harvard Medical School by Keyword "chemoresistance"

Now showing items 1-3 of 3

    • Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway 

      Wu, Qiong; Wang, Rui; Yang, Qingling; Hou, Xin; Chen, Sulian; Hou, Yueyue; Chen, Changjie; Yang, Yan; Miele, Lucio; Sarkar, Fazlul H; Chen, Yuqing; Wang, Zhiwei (Impact Journals LLC, 2013)
      Hepatocellular carcinoma (HCC) is one of the common malignances in the world and has high mortality in part due to development of acquired drug resistance. Therefore, it is urgent to investigate the molecular mechanism of ...

    • Inhibition of Notch Signaling in Combination with Paclitaxel Reduces Platinum-Resistant Ovarian Tumor Growth 

      Groeneweg, Jolijn W.; DiGloria, Celeste M.; Yuan, Jing; Richardson, William S.; Growdon, Whitfield B.; Sathyanarayanan, Sriram; Foster, Rosemary; Rueda, Bo R. (Frontiers Media S.A., 2014)
      Introduction: Ovarian cancer (OvCa) is the most lethal gynecologic malignancy in the United States because of chemoresistant recurrent disease. Our objective was to investigate the efficacy of inhibiting the Notch pathway ...

    • SALL4 is a new target in endometrial cancer 

      Li, Ailing; Jiao, Yisheng; Yong, Kol Jia; Wang, Fei; Gao, Chong; Yan, Benedict; Srivastava, Supriya; Lim, Gkeok Stzuan Diana; Tang, Ping; Yang, Henry; Tenen, Daniel G; Chai, Li (2014)
      Aggressive cancers and embryonic stem (ES) cells share a common gene expression signature. Identifying the key factors/pathway(s) within this ES signature responsible for the aggressiveness of cancers can lead to a potential ...