Browsing Harvard Medical School by Keyword "drug research and development"

Now showing items 1-3 of 3

    • Enhancement of Naringenin Bioavailability by Complexation with Hydroxypropoyl-β-Cyclodextrin 

      Shulman, Maria; Cohen, Merav; Soto-Gutierrez, Alejandro; Yagi, Hiroshi; Wang, Hongyun; Goldwasser, Jonathan; Lee-Parsons, Carolyn W.; Benny-Ratsaby, Ofra; Yarmush, Martin Leon; Nahmias, Yaakov (Public Library of Science, 2011)
      The abundant flavonoid aglycone, naringenin, which is responsible for the bitter taste in grapefruits, has been shown to possess hypolipidemic and anti-inflammatory effects both in vitro and in vivo. Recently, our group ...

    • A High-Throughput Screen Identifies a New Natural Product with Broad-Spectrum Antibacterial Activity 

      Ymele-Leki, Patrick; Cao, Shugeng; Sharp, Jared D'Alonzo; Lambert, Kathleen G; McAdam, Alexander John; Husson, Robert N; Tamayo, Giselle; Clardy, Jon C.; Watnick, Paula Ivonne (Public Library of Science, 2012)
      Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and ...

    • The Prevalence and Cost of Unapproved Uses of Top-Selling Orphan Drugs 

      Kesselheim, Aaron Seth; Myers, Jessica Amelia; Solomon, Daniel Hal; Winkelmayer, Wolfgang C.; Levin, Raisa; Avorn, Jerry (Public Library of Science, 2012)
      Introduction: The Orphan Drug Act encourages drug development for rare conditions. However, some orphan drugs become top sellers for unclear reasons. We sought to evaluate the extent and cost of approved and unapproved ...