Browsing HMS Scholarly Articles by Author "Adams, Mark D."

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    • Assessing the Evolutionary Impact of Amino Acid Mutations in the Human Genome 

      Boyko, Adam R.; Indap, Amit R.; Degenhardt, Jeremiah D.; Hernandez, Ryan D.; Lohmueller, Kirk E.; Adams, Mark D.; Schmidt, Steffen; Sninsky, John J.; White, Thomas J.; Nielsen, Rasmus; Bustamante, Carlos D.; Williamson, Scott H.; Sunyaev, Shamil R.; Clark, Andrew G. (Public Library of Science, 2008)
      Quantifying the distribution of fitness effects among newly arising mutations in the human genome is key to resolving important debates in medical and evolutionary genetics. Here, we present a method for inferring this ...