Browsing HMS Scholarly Articles by Author "Alt, Frederick W."

Now showing items 1-7 of 7

    • 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis 

      Morales, Julio C.; Franco, Sonia; Murphy, Michael M.; Bassing, Craig H.; Mills, Kevin D.; Adams, Melissa M.; Walsh, Nicole C.; Manis, John P.; Rassidakis, George Z.; Alt, Frederick W.; Carpenter, Phillip B. (National Academy of Sciences, 2006)
      p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded breaks where it associates with various DNA repair/cell cycle factors including the H2AX histone variant. Mice deficient for 53BP1 ...

    • Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4 

      Boboila, Cristian; Yan, Catherine; Wesemann, Duane R.; Jankovic, Mila; Wang, Jing H.; Manis, John; Nussenzweig, Andre; Nussenzweig, Michel; Alt, Frederick W. (Rockefeller University Press, 2010)
      The classical nonhomologous end-joining (C-NHEJ) DNA double-strand break (DSB) repair pathway employs the Ku70/80 complex (Ku) for DSB recognition and the XRCC4/DNA ligase 4 (Lig4) complex for ligation. During IgH class ...

    • Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development 

      Rooney, Sean; Alt, Frederick W.; Sekiguchi, JoAnn; Manis, John P. (National Academy of Sciences, 2005)
      Assembly of Ig genes in B lineage cells involves two distinct DNA rearrangements. In early B cell development, site-specific double strand breaks (DSBs) at germ-line V, D, and J gene segments are joined via nonhomologous ...

    • Deficiencies of GM-CSF and Interferon γ Link Inflammation and Cancer 

      Enzler, Thomas; Gillessen, Silke; Manis, John P.; Ferguson, David; Fleming, James; Alt, Frederick W.; Mihm, Martin; Dranoff, Glenn (Rockefeller University Press, 2003)
      Chronic inflammation contributes to carcinogenesis, but the underlying mechanisms are poorly understood. We report that aged granulocyte-macrophage colony stimulating factor (GM-CSF)-deficient mice develop a systemic lupus ...

    • Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice 

      Cheng, Hwei-Ling; Mostoslavsky, Raul; Saito, Shin'ichi; Manis, John P.; Gu, Yansong; Patel, Parin; Bronson, Roderick; Appella, Ettore; Alt, Frederick W.; Chua, Katrin F. (National Academy of Sciences, 2003)
      SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in deacetylating the p53 tumor suppressor protein ...

    • The Fundamental Role of Chromatin Loop Extrusion in Physiological V(D)J Recombination 

      Zhang, Yu; Zhang, Xuefei; Ba, Zhaoqing; Liang, Zhuoyi; Hu, Hongli; Lou, Jiangman; Kyritsis, Nia; Zurita, Jeffrey; Shamim, Muhammad S.; Presser Aiden, Aviva; Lieberman Aiden, Erez; Alt, Frederick W.; Dring, Edward (Springer Science and Business Media LLC, 2019-09)
      RAG endonuclease initiates IgH locus (Igh) V(D)J assembly in progenitor (pro)-B cells by joining Ds to JHs, before joining upstream VHs to DJH intermediates1. In mouse pro-B cells, the CTCF-binding element (CBE)-anchored ...

    • Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program 

      Green, Michael R.; Monti, Stefano; Dalla-Favera, Riccardo; Pasqualucci, Laura; Walsh, Nicole C.; Schmidt-Supprian, Marc; Kutok, Jeffery L.; Rodig, Scott J.; Neuberg, Donna S.; Rajewsky, Klaus; Golub, Todd R.; Alt, Frederick W.; Shipp, Margaret A.; Manis, John P. (National Academy of Sciences, 2011)
      We utilized gene expression profiling of a comprehensive panel of purified developmentally defined normal murine B cells to identify unique transcriptional signatures for each subset. To elucidate transcription factor ...