Browsing HMS Scholarly Articles by Author "Chung, Jaehoon"

Now showing items 1-13 of 13

    • Ascites analysis by a microfluidic chip allows tumor-cell profiling 

      Peterson, Vanessa M.; Castro, Cesar M.; Chung, Jaehoon; Miller, Nathan C.; Ullal, Adeeti V.; Castano, Maria D.; Penson, Richard T.; Lee, Hakho; Birrer, Michael J.; Weissleder, Ralph (National Academy of Sciences, 2013)
      Ascites tumor cells (ATCs) represent a potentially valuable source of cells for monitoring treatment of ovarian cancer as it would obviate the need for more invasive surgical biopsies. The ability to perform longitudinal ...

    • Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma 

      Shao, Huilin; Chung, Jaehoon; Lee, Kyungheon; Balaj, Leonora; Min, Changwook; Carter, Bob S.; Hochberg, Fred H.; Breakefield, Xandra O.; Lee, Hakho; Weissleder, Ralph (Nature Pub. Group, 2015)
      Real-time monitoring of drug efficacy in glioblastoma multiforme (GBM) is a major clinical problem as serial re-biopsy of primary tumours is often not a clinical option. MGMT (O6-methylguanine DNA methyltransferase) and ...

    • Diagnostic technologies for circulating tumour cells and exosomes 

      Shao, Huilin; Chung, Jaehoon; Issadore, David (Portland Press Ltd., 2016)
      Circulating tumour cells (CTCs) and exosomes are promising circulating biomarkers. They exist in easily accessible blood and carry large diversity of molecular information. As such, they can be easily and repeatedly obtained ...

    • Impact of cardiovascular magnetic resonance on management and clinical decision-making in heart failure patients 

      Abbasi, Siddique A; Ertel, Andrew; Shah, Ravi V; Dandekar, Vineet; Chung, Jaehoon; Bhat, Geetha; Desai, Ankit A; Kwong, Raymond Y; Farzaneh-Far, Afshin (BioMed Central, 2013)
      Background: Cardiovascular magnetic resonance (CMR) can provide important diagnostic and prognostic information in patients with heart failure. However, in the current health care environment, use of a new imaging modality ...

    • Magnetic Barcode Assay for Genetic Detection of Pathogens 

      Liong, Monty; Hoang, Anh N.; Chung, Jaehoon; Gural, Nil; Ford, Christopher B.; Min, Changwook; Shah, Rupal R.; Ahmad, Rushdy; Fernandez-Suarez, Marta; Fortune, Sarah M.; Toner, Mehmet; Lee, Hakho; Weissleder, Ralph (Nature Research (part of Springer Nature), 2013)
      The task of rapidly identifying patients infected with Mycobacterium tuberculosis in resource-constrained environments remains a challenge. A sensitive and robust platform that does not require bacterial isolation or culture ...

    • Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles 

      Rho, Junsung; Chung, Jaehoon; Im, Hyungsoon; Liong, Monty; Shao, Huilin; Castro, Cesar M.; Weissleder, Ralph; Lee, Hakho (American Chemical Society, 2013)
      During the course of their lifespan, erythrocytes actively shed phospholipid-bound microvesicles (MVs). In stored blood, the number of these erythrocyte-derived MVs has been observed to increase over time, suggesting their ...

    • Microfluidic Cell Sorter (μFCS) for On-chip Capture and Analysis of Single cells 

      Chung, Jaehoon; Shao, Huilin; Reiner, Thomas; Issadore, David; Weissleder, Ralph; Lee, Hakho (Wiley, 2012)

    • Miniature magnetic resonance system for point-of-care diagnostics 

      Issadore, David; Min, Changwook; Liong, Monty; Chung, Jaehoon; Weissleder, Ralph; Lee, Hakho (Royal Society of Chemistry, 2011)
      We have developed a next generation, miniaturized platform to diagnose disease at the point-of-care using diagnostic magnetic resonance (DMR-3). Utilizing a rapidly growing library of functionalized magnetic nanoparticles, ...

    • Miniaturized Nuclear Magnetic Resonance Platform for Detection and Profiling of Circulating Tumor Cells 

      Castro, Cesar; Ghazani, Arezou; Chung, Jaehoon; Shao, Huilin; Issadore, David; Yoon, Tae-Jong; Weissleder, Ralph; Lee, Hakho (Royal Society of Chemistry, 2014)

    • Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury 

      Chung, Hyun Jung; Pellegrini, Kathryn L.; Chung, Jaehoon; Wanigasuriya, Kamani; Jayawardene, Innocent; Lee, Kyungheon; Lee, Hakho; Vaidya, Vishal S.; Weissleder, Ralph (Public Library of Science, 2015)
      The high incidence of acute and chronic kidney injury due to various environmental factors such as heavy metals or chemicals has been a major problem in developing countries. However, the diagnosis of kidney injury in these ...

    • Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy 

      Shao, Huilin; Chung, Jaehoon; Balaj, Leonora; Charest, Alain; Bigner, Darell D.; Carter, Bob S.; Hochberg, Fred H.; Breakefield, Xandra O.; Weissleder, Ralph; Lee, Hakho (Nature Research, 2012)
      Glioblastomas shed large quantities of small, membrane-bound microvesicles into the circulation. Although these hold promise as potential biomarkers of therapeutic response, their identification and quantification remain ...

    • Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip 

      Chung, Jaehoon; Issadore, David; Ullal, Adeeti; Lee, Kyungheon; Weissleder, Ralph; Lee, Hakho (AIP Publishing, 2013)
      We present a hybrid magnetic/size-sorting (HMSS) chip for isolation and molecular analyses of circulating tumor cells (CTCs). The chip employs both negative and positive cell selection in order to provide high throughput, ...

    • Self-Assembled Magnetic Filter for Highly Efficient Immunomagnetic Separation 

      Issadore, David; Shao, Huilin; Chung, Jaehoon; Newton, Andita; Pittet, Mikael; Weissleder, Ralph; Lee, Hakho (Royal Society of Chemistry, 2011)
      We have developed a compact and inexpensive microfluidic chip, the self-assembled magnetic filter, to efficiently remove magnetically tagged cells from suspension. The self-assembled magnetic filter consists of a microfluidic ...