Browsing HMS Scholarly Articles by Author "Hutchinson, John"
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Allele-Specific Methylation Occurs at Genetic Variants Associated with Complex Disease
Hutchinson, John N.; Raj, Towfique; Fagerness, Jes; Stahl, Eli; Viloria, Fernando T.; Gimelbrant, Alexander; Seddon, Johanna; Daly, Mark; Chess, Andrew; Plenge, Robert (Public Library of Science, 2014)We hypothesize that the phenomenon of allele-specific methylation (ASM) may underlie the phenotypic effects of multiple variants identified by Genome-Wide Association studies (GWAS). We evaluate ASM in a human population ... -
Comparison of multiplexed reduced representation bisulfite sequencing (mRRBS) with the 450K Illumina Human BeadChip: from concordance to practical applications for methylomic profiling in epigenetic epidemiologic studies
Carmona, Juan Jose; Izzi, Benedetta; Just, Allan Carpenter; Barupal, Jitendra; Binder, Alexandra Margaret Lynn; Hutchinson, John N; Hofmann, Oliver Marc; Schwartz, Joel David; Baccarelli, Andrea; Michels, Karin B. (BioMed Central, 2013)