Browsing HMS Scholarly Articles by Author "Dunn, Gavin P."

Now showing items 1-3 of 3

    • Emerging insights into the molecular and cellular basis of glioblastoma 

      Dunn, Gavin P.; Rinne, Mikael L.; Wykosky, Jill; Genovese, Giannicola; Quayle, Steven N.; Dunn, Ian F.; Agarwalla, Pankaj K.; Chheda, Milan G.; Campos, Benito; Wang, Alan; Brennan, Cameron; Ligon, Keith L.; Furnari, Frank; Cavenee, Webster K.; Depinho, Ronald A.; Chin, Lynda; Hahn, William C. (Cold Spring Harbor Laboratory Press, 2012)
      Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. ...

    • In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene 

      Dunn, Gavin P.; Cheung, Hiu Wing; Agarwalla, Pankaj K.; Thomas, Sapana; Zektser, Yulia; Karst, Alison M.; Boehm, Jesse S.; Weir, Barbara A.; Berlin, Aaron M.; Zou, Lihua; Getz, Gad; Liu, Joyce F.; Hirsch, Michelle; Vazquez, Francisca; Root, David E.; Beroukhim, Rameen; Drapkin, Ronny; Hahn, William C. (National Academy of Sciences, 2014)
      High-grade serous ovarian cancers are characterized by widespread recurrent copy number alterations. Although some regions of copy number change harbor known oncogenes and tumor suppressor genes, the genes targeted by the ...

    • Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM 

      Wiedemeyer, W. Ruprecht; Dunn, Ian F.; Quayle, Steven N.; Zhang, Jianhua; Chheda, Milan G.; Dunn, Gavin P.; Zhuang, Li; Rosenbluh, Joseph; Chen, Shujuan; Xiao, Yonghong; Shapiro, Geoffrey I.; Hahn, William C.; Chin, Lynda (National Academy of Sciences, 2010)
      Glioblastoma multiforme (GBM) is a fatal primary brain tumor harboring myriad genetic and epigenetic alterations. The recent multidimensional analysis of the GBM genome has provided a more complete view of the landscape ...