Browsing HMS Scholarly Articles by Author "Brain, Joseph"

Now showing items 1-13 of 13

    • The avian respiratory system: a unique model for studies of respiratory toxicosis and for monitoring air quality 

      Brown, Richard C; Brain, Joseph David; Wang, Ning (Environmental Health Perspectives, 1997)
      There are many distinct differences (morphologic, physiologic, and mechanical) between the bird's lung-air-sac respiratory system and the mammalian bronchoalveolar lung. In this paper, we review the physiology of the avian ...

    • Childhood Leukemia: Electric and Magnetic Fields as Possible Risk Factors 

      Brain, Joseph David; Kavet, Robert I.; McCormick, David L.; Poole, Charles; Silverman, Lewis Barry; Smith, Thomas J.; Valberg, Peter A.; Van Etten, R. A.; Weaver, James (Environmental Health Perspectives, 2003)
      Numerous epidemiologic studies have reported associations between measures of power-line electric or magnetic fields (EMFs) and childhood leukemia. The basis for such associations remains unexplained. In children, acute ...

    • Effects of a perfluorochemical emulsion on the fate of circulating Pseudomonas aeruginosa 

      Brain, Joseph David; Molina, Ramon M.; DeCamp, Malcolm; Warner, Angeline (American Physiology Association, 1999)
      Because mononuclear phagocytes take up perfluorochemical emulsions (PFCE), we examined how prior treatment with PFCE affects the fate of circulating bacteria. Rats were preinjected with three daily intravenous injections ...

    • Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis 

      Vandivier, R. William; Fadok, Valerie A.; Hoffmann, Peter R.; Bratton, Donna L.; Penvari, Churee; Brown, Kevin K.; Brain, Joseph David; Accurso, Frank J.; Henson, Peter M. (American Society for Clinical Investigation, 2002)
      Cystic fibrosis is characterized by an early and sustained influx of inflammatory cells into the airways and by release of proteases. Resolution of inflammation is normally associated with the orderly removal of dying ...

    • Engineering safer-by-design silica-coated ZnO nanorods with reduced DNA damage potential 

      Sotiriou, Georgios; Wright, Christa Young; Murdaugh, Kimberly; Darrah, Thomas H.; Pyrgiotakis, Georgios; Elder, Alison; Brain, Joseph David; Demokritou, Phil K. (Royal Society of Chemistry (RSC), 2014)
      Zinc oxide (ZnO) nanoparticles absorb UV light efficiently while remaining transparent in the visible light spectrum rendering them attractive in cosmetics and polymer films. Their broad use, however, raises concerns ...

    • Environmental Mold and Mycotoxin Exposures Elicit Specific Cytokine and Chemokine Responses 

      Rosenblum Lichtenstein, Jamie H.; Hsu, Yi-Hsiang; Gavin, Igor M.; Donaghey, Thomas C.; Molina, Ramon M.; Thompson, Khristy J.; Chi, Chih-Lin; Gillis, Bruce S.; Brain, Joseph D. (Public Library of Science, 2015)
      Background: Molds can cause respiratory symptoms and asthma. We sought to use isolated peripheral blood mononuclear cells (PBMCs) to understand changes in cytokine and chemokine levels in response to mold and mycotoxin ...

    • In vivo evaluation of chemical biopersistence of nonfibrous inorganic particles. 

      Brain, Joseph David; Godleski, John Joseph; Kreyling, W (1994)
      The lung's response to deposited particles may depend upon the physical-chemical properties of the particles, the amount initially deposited, and the persistence of the particles. Clearance involves mucociliary transport ...

    • Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring 

      Molina, Ramon M.; Phattanarudee, Siripan; Kim, Jonghan; Thompson, Khristy J.; Wessling-Resnick, Marianne; Maher, Timothy Richard; Brain, Joseph David (Elsevier BV, 2011)
      Manganese (Mn) and lead (Pb) exposures during developmental period can impair development by direct neurotoxicity or through interaction with iron metabolism. Therefore, we examined the effects of maternal ingestion of Mn ...

    • Macrophage Damage in Relation to the Pathogenesis of Lung Diseases 

      Brain, Joseph David (National Institute of Environmental Health Sciences, 1980)
      Pulnonary macrophages are important since their migratory patterns and behavior are often pivotal events in the pathogenesis of pulmonary disease. Alveolar macrophages act to decrease the probability of particle penetration ...

    • Pulmonary Toxicity in Hamsters of Smoke Particles from Kuwaiti Oil Fires. 

      Brain, Joseph David; Long, N. C.; Wolfthal, S F; Dumyahn, T; Dockery, Douglas W. (National Institute of Environmental Health Sciences, 1998)
      The Kuwaiti oil wells set on fire by retreating Iraqi troops at the end of the Persian Gulf War released complex particles, inorganic and organic gases, and hydrocarbons into the atmosphere, damaging the environment where ...

    • Reduction of Pulmonary Toxicity of Stachybotrys chartarum Spores by Methanol Extraction of Mycotoxins 

      Rao, Charles Albert Sakakini Nagaraja; Brain, Joseph David; Burge, Harriet Ann (American Society for Microbiology, 2000)
      The fungus Stachybotrys chartarum has been implicated in cases of nonspecific indoor air quality complaints in adults and in cases of pulmonary hemorrhaging in infants. The effects that have been described have been ...

    • The Respiratory Tract and the Environment 

      Brain, Joseph David (National Institute of Environmental Health Sciences, 1977)
      The primary determinants of pulmonary disease are environmental. The same thinness and delicacy of the air-blood barrier which allows rapid exchange of oxygen and carbon dioxide also reduce its effectiveness as a barrier ...

    • Strain Differences Influence Murine Pulmonary Responses to Stachybotrys chartarum 

      Rosenblum Lichtenstein, Jamie H.; Molina, Ramon M.; Donaghey, Thomas Clark; Brain, Joseph David (American Thoracic Society, 2006)
      When the fungus Stachybotrys chartarum is inhaled, its mycotoxins may cause lung injury and inflammation. The severity of human responses to S. chartarum in both occupational and home settings varies widely. To explore ...