Browsing HMS Scholarly Articles by Author "Ma, Gaoen"
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The Clustered, Regularly Interspaced, Short Palindromic Repeats-associated Endonuclease 9 (CRISPR/Cas9)-created MDM2T309G Mutation Enhances Vitreous-induced Expression of MDM2 and Proliferation and Survival of Cells
Duan, Yajian; Ma, Gaoen; Huang, Xionggao; D'Amore, Patricia Ann; Zhang, Feng; Lei, Hetian (American Society for Biochemistry & Molecular Biology (ASBMB), 2016)The 309G allele of single nucleotide polymorphisms (SNPs) in the mouse double minute (MDM2) promoter locus is associated with a higher risk of cancer and proliferative vitreoretinopathy (PVR), but as to whether this SNP ... -
Prevention of Proliferative Vitreoretinopathy by Suppression of Phosphatidylinositol 5-Phosphate 4-Kinases
Ma, Gaoen; Duan, Yajian; Huang, Xionggao; Qian, Cynthia X.; Chee, Yewlin; Mukai, Shizuo; Cui, Jing; Samad, Arif; Matsubara, Joanne Aiko; Kazlauskas, Andrius; D'Amore, Patricia A.; Gu, Shuyan; Lei, Hetian (The Association for Research in Vision and Ophthalmology, 2016)Purpose Previous studies have shown that vitreous stimulates degradation of the tumor suppressor protein p53 and that knockdown of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Kα and -β) abrogates proliferation of ...