Browsing HMS Scholarly Articles by Author "Li, Chun"

Now showing items 1-4 of 4

    • Functional Characterization of HLA-G+ Regulatory T Cells in HIV-1 Infection 

      Li, Chun; Toth, Ilona; Schulze zur Wiesch, Julian; Pereyra, Florencia; Rychert, Jennifer Ann; Rosenberg, Eric Scott; van Lunzen, Jan; Lichterfeld, Mathias; Yu, Xu (Public Library of Science, 2013)
      Regulatory T cells represent a specialized subpopulation of T lymphocytes that may modulate spontaneous HIV-1 disease progression by suppressing immune activation or inhibiting antiviral T cell immune responses. While the ...

    • HIV-1 persistence in CD4+ T cells with stem cell-like properties 

      Buzon, Maria J.; Sun, Hong; Li, Chun; Shaw, Amy; Seiss, Katherine; Ouyang, Zhengyu; Martin-Gayo, Enrique; Leng, Jin; Henrich, Timothy J.; Li, Jonathan Z.; Pereyra, Florencia; Zurakowski, Ryan; Walker, Bruce D.; Rosenberg, Eric S.; Yu, Xu G.; Lichterfeld, Mathias (2014)
      Cellular HIV-1 reservoirs that persist despite antiretroviral treatment are incompletely defined. We show that during suppressive antiretroviral therapy, CD4+ T memory stem cells (TSCM) harbor high per-cell levels of HIV-1 ...

    • Identification of New Genetic Risk Variants for Type 2 Diabetes 

      Shu, Xiao Ou; Long, Jirong; Cai, Qiuyin; Xiang, Yong-Bing; Tai, E. Shyong; Li, Xiangyang; Lin, Xu; Chow, Wong-Ho; Go, Min Jin; Seielstad, Mark; Li, Huaixing; Yu, Kai; Wen, Wanqing; Shi, Jiajun; Han, Bok-Ghee; Sim, Xue Ling; Liu, Liegang; Kim, Hyung-Lae; Ng, Daniel P. K.; Lee, Jong-Young; Gao, Yu-Tang; Visscher, Peter M.; Qi, Lu; Cho, Yoon-Jae; Bao, Wei; Cornelis, Marilyn; Qi, Qibin; Kim, Young Jin; Li, Chun; Zheng, Wei; Hu, Frank B. (Public Library of Science, 2010)
      Although more than 20 genetic susceptibility loci have been reported for type 2 diabetes (T2D), most reported variants have small to moderate effects and account for only a small proportion of the heritability of T2D, ...

    • Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk 

      Zhang, Ben; Jia, Wei-Hua; Matsuda, Koichi; Kweon, Sun-Seog; Matsuo, Keitaro; Xiang, Yong-Bing; Shin, Aesun; Jee, Sun Ha; Kim, Dong-Hyun; Cai, Qiuyin; Long, Jirong; Shi, Jiajun; Wen, Wanqing; Yang, Gong; Zhang, Yanfeng; Li, Chun; Li, Bingshan; Guo, Yan; Ren, Zefang; Ji, Bu-Tian; Pan, Zhi-Zhong; Takahashi, Atsushi; Shin, Min-Ho; Matsuda, Fumihiko; Gao, Yu-Tang; Oh, Jae Hwan; Kim, Soriul; Ahn, Yoon-Ok; Chan, Andrew T; Chang-Claude, Jenny; Slattery, Martha L.; Gruber, Stephen B.; Schumacher, Fredrick R.; Stenzel, Stephanie L.; Casey, Graham; Kim, Hyeong-Rok; Jeong, Jin-Young; Park, Ji Won; Li, Hong-Lan; Hosono, Satoyo; Cho, Sang-Hee; Kubo, Michiaki; Shu, Xiao-Ou; Zeng, Yi-Xin; Zheng, Wei (2014)
      Known genetic loci explain only a small proportion of the familial relative risk of colorectal cancer (CRC). We conducted the largest genome-wide association study in East Asians with 14,963 CRC cases and 31,945 controls ...