Browsing HMS Scholarly Articles by Author "Friesen, Max"
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Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9
Mandal, Pankaj Kumar; Ferreira, Leonardo Manuel Ramos; Collins, Ryan; Meissner, Torsten B; Boutwell, C; Friesen, Max; Vrbanac, Vladimir; Garrison, Brian Scott; Stortchevoi, Alexei; Bryder, David; Musunuru, Kiran; Brand, Harrison Andrew; Tager, Andrew Martin; Allen, Todd; Talkowski, Michael Edward; Rossi, Derrick J; Cowan, Chad A. (Elsevier BV, 2014)Genome editing via CRISPR/Cas9 has rapidly become the tool of choice by virtue of its efficacy and ease of use. However, CRISPR/Cas9-mediated genome editing in clinically relevant human somatic cells remains untested. Here, ...