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    • Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE 

      Nguyen, H. Bryant; Jaehne, Anja Kathrin; Jayaprakash, Namita; Semler, Matthew W.; Hegab, Sara; Yataco, Angel Coz; Tatem, Geneva; Salem, Dhafer; Moore, Steven; Boka, Kamran; Gill, Jasreen Kaur; Gardner-Gray, Jayna; Pflaum, Jacqueline; Domecq, Juan Pablo; Hurst, Gina; Belsky, Justin B.; Fowkes, Raymond; Elkin, Ronald B.; Simpson, Steven Q.; Falk, Jay L.; Singer, Daniel J.; Rivers, Emanuel P. (BioMed Central, 2016)
      Prior to 2001 there was no standard for early management of severe sepsis and septic shock in the emergency department. In the presence of standard or usual care, the prevailing mortality was over 40-50 %. In response, a ...