Browsing HMS Scholarly Articles by Author "Borsook, David"
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Abdominal Pain, the Adolescent and Altered Brain Structure and Function
Hubbard, Catherine S.; Becerra, Lino; Heinz, Nicole; Ludwick, Allison; Rasooly, Tali; Wu, Rina; Johnson, Adriana; Schechter, Neil L.; Borsook, David; Nurko, Samuel (Public Library of Science, 2016)Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder of unknown etiology. Although relatively common in children, how this condition affects brain structure and function in a pediatric population ... -
Altered Hypothalamic Functional Connectivity with Autonomic Circuits and the Locus Coeruleus in Migraine
Moulton, Eric A.; Becerra, Lino; Johnson, Adriana; Burstein, Rami; Borsook, David (Public Library of Science, 2014)The hypothalamus has been implicated in migraine based on the manifestation of autonomic symptoms with the disease, as well as neuroimaging evidence of hypothalamic activation during attacks. Our objective was to determine ... -
An Approach to Localizing Corneal Pain Representation in Human Primary Somatosensory Cortex
Moulton, Eric Alan; Becerra, Lino Renan; Rosenthal, Perry; Borsook, David (Public Library of Science, 2012)The cornea has been a focus of animal electrophysiological research for decades, but little is known regarding its cortical representation in the human brain. This study attempts to localize the somatotopic representation ... -
Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal
Hubbard, Catherine S.; Becerra, Lino; Smith, Jonathan H.; DeLange, Justin M.; Smith, Ryan M.; Black, David F.; Welker, Kirk M.; Burstein, Rami; Cutrer, Fred M.; Borsook, David (Frontiers Media S.A., 2016)The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥15 headache days/month) to episodic (EM; <15 headache days/month) migraine following prophylactic ... -
Calcitonin Gene-Related Peptide Modulates Heat Nociception in the Human Brain - An fMRI Study in Healthy Volunteers
Asghar, Mohammad Sohail; Becerra, Lino; Larsson, Henrik B. W.; Borsook, David; Ashina, Messoud (Public Library of Science, 2016)Background: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP ... -
Capturing Pain in the Cortex during General Anesthesia: Near Infrared Spectroscopy Measures in Patients Undergoing Catheter Ablation of Arrhythmias
Kussman, Barry D.; Aasted, Christopher M.; Yücel, Meryem A.; Steele, Sarah C.; Alexander, Mark E.; Boas, David A.; Borsook, David; Becerra, Lino (Public Library of Science, 2016)The predictability of pain makes surgery an ideal model for the study of pain and the development of strategies for analgesia and reduction of perioperative pain. As functional near-infrared spectroscopy reproduces the ... -
Colocalized Structural and Functional Changes in the Cortex of Patients with Trigeminal Neuropathic Pain
DaSilva, Alexandre F.; Becerra, Lino Renan; Pendse, Gautam; Chizh, Boris; Tully, Shannon; Borsook, David (Public Library of Science, 2008)Background: Recent data suggests that in chronic pain there are changes in gray matter consistent with decreased brain volume, indicating that the disease process may produce morphological changes in the brains of those ... -
Comparison of Evoked vs. Spontaneous Tics in a Patient with Trigeminal Neuralgia (Tic Doloureux)
Borsook, David; Moulton, Eric Alan; Pendse, Gautam; Morris, Susie; Cole, Sadie Hannah; Aiello-Lammens, Matthew; Scrivani, Steven; Becerra, Lino Renan (BioMed Central, 2007)A 53-year old woman with tic doloureaux, affecting her right maxillary division of the trigeminal nerve (V2), could elicit shooting pains by slightly tapping her teeth when off medication. The pains, which she normally ... -
Cortico–Cortical Connections of Primary Sensory Areas and Associated Symptoms in Migraine
Hodkinson, Duncan J.; Veggeberg, Rosanna; Kucyi, Aaron; van Dijk, Koene R. A.; Wilcox, Sophie L.; Scrivani, Steven J.; Burstein, Rami; Becerra, Lino; Borsook, David (Society for Neuroscience, 2016)Abstract Migraine is a recurring, episodic neurological disorder characterized by headache, nausea, vomiting, and sensory disturbances. These events are thought to arise from the activation and sensitization of neurons ... -
Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow
Linnman, Clas; Catana, Ciprian; Svärdsudd, Kurt; Appel, Lieuwe; Engler, Henry; Långström, Bengt; Sörensen, Jens; Furmark, Tomas; Fredrikson, Mats; Borsook, David; Peterson, Magnus (Public Library of Science, 2016)Substance P is released in painful and inflammatory conditions, affecting both peripheral processes and the central nervous system neurokinin 1 (NK1) receptor. There is a paucity of data on human brain alterations in NK1 ... -
Diffuse Optical Tomography Activation in the Somatosensory Cortex: Specific Activation by Painful vs. Non-Painful Thermal Stimuli
Becerra, Lino Renan; Harris, William Hamilton; Grant, Margaret; George, Edward E.; Boas, David A.; Borsook, David (Public Library of Science, 2009)Background: Pain is difficult to assess due to the subjective nature of self-reporting. The lack of objective measures of pain has hampered the development of new treatments as well as the evaluation of current ones. ... -
Excitatory Neurotransmitters in Brain Regions in Interictal Migraine Patients
Prescot, Andrew; Becerra, Lino Renan; Pendse, Gautam; Tully, Shannon; Jensen, Eric; Hargreaves, Richard; Renshaw, Perry Franklin; Burstein, Rami; Borsook, David (BioMed Central, 2009)Objective: To examine biochemical differences in the anterior cingulate cortex (ACC) and insula during the interictal phase of migraine patients. We hypothesized that there may be differences in levels of excitatory amino ... -
Frontal Lobe Hemodynamic Responses to Painful Stimulation: A Potential Brain Marker of Nociception
Aasted, Christopher M.; Yücel, Meryem A.; Steele, Sarah C.; Peng, Ke; Boas, David A.; Becerra, Lino; Borsook, David (Public Library of Science, 2016)The purpose of this study was to use functional near-infrared spectroscopy (fNIRS) to examine patterns of both activation and deactivation that occur in the frontal lobe in response to noxious stimuli. The frontal lobe was ... -
Increased Functional Activation of Limbic Brain Regions during Negative Emotional Processing in Migraine
Wilcox, Sophie L.; Veggeberg, Rosanna; Lemme, Jordan; Hodkinson, Duncan J.; Scrivani, Steven; Burstein, Rami; Becerra, Lino; Borsook, David (Frontiers Media S.A., 2016)Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light, and sound) has been extensively ... -
Interictal dysfunction of a brainstem descending modulatory center in migraine patients
Tully, Shannon; Hargreaves, Richard; Matsunami, Hiroaki; Moulton, Eric Alan; Burstein, Rami; Becerra, Lino Renan; Borsook, David (Public Library of Science, 2008)Background: The brainstem contains descending circuitry that can modulate nociceptive processing (neural signals associated with pain) in the dorsal horn of the spinal cord and the medullary dorsal horn. In migraineurs, ... -
A Key Role of the Basal Ganglia in Pain and Analgesia - Insights Gained Through Human Functional Imaging
Borsook, David; Upadhyay, Jaymin; Chudler, Eric H; Becerra, Lino Renan (BioMed Central, 2010)The basal ganglia (BG) are composed of several nuclei involved in neural processing related to the execution of motor, cognitive and emotional activities. Preclinical and clinical data have implicated a role for these ... -
Neurochemical Pathways That Converge on Thalamic Trigeminovascular Neurons: Potential Substrate for Modulation of Migraine by Sleep, Food Intake, Stress and Anxiety
Noseda, Rodrigo; Kainz, Vanessa; Borsook, David; Burstein, Rami (Public Library of Science, 2014)Dynamic thalamic regulation of sensory signals allows the cortex to adjust better to rapidly changing behavioral, physiological and environmental demands. To fulfill this role, thalamic neurons must themselves be subjected ... -
Nocebo Effect in Randomized Clinical Trials of Antidepressants in Children and Adolescents: Systematic Review and Meta-Analysis
Rojas-Mirquez, Johanna Carolina; Rodriguez-Zuñiga, Milton Jose Max; Bonilla-Escobar, Francisco Javier; Garcia-Perdomo, Herney Andres; Petkov, Mike; Becerra, Lino; Borsook, David; Linnman, Clas (Frontiers Media S.A., 2014)Objective:: To compare the incidence of adverse events between active and placebo arms of randomized clinical trials in depressive children and adolescents (C&A) with antidepressant treatments, in order to look for ... -
Ocular neuropathic pain
Rosenthal, Perry; Borsook, David (BMJ Publishing Group, 2015)As the biological alarm of impending or actual tissue damage, pain is essential for our survival. However, when it is initiated and/or sustained by dysfunctional elements in the nociceptive system, it is itself a disease ... -
Oculofacial Pain: Corneal Nerve Damage Leading to Pain Beyond the Eye
Rosenthal, Perry; Borsook, David; Moulton, Eric A. (The Association for Research in Vision and Ophthalmology, 2016)The cornea is supplied principally by the ophthalmic branch of the trigeminal nerve and is the most densely innervated organ in the human body. Under normal conditions, the corneal nerve terminals incorporate sensors that ...