Browsing HMS Scholarly Articles by Author "Murugan, Rajamanickam"
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On the Minimization of Fluctuations in the Response Times of Autoregulatory Gene Networks
Murugan, Rajamanickam; Kreiman, Gabriel (Elsevier BV, 2011)The temporal dynamics of the concentrations of several proteins are tightly regulated, particularly for critical nodes in biological networks such as transcription factors. An important mechanism to control transcription ... -
Theory on the Coupled Stochastic Dynamics of Transcription and Splice-Site Recognition
Murugan, Rajamanickam; Kreiman, Gabriel (Public Library of Science, 2012)Eukaryotic genes are typically split into exons that need to be spliced together to form the mature mRNA. The splicing process depends on the dynamics and interactions among transcription by the RNA polymerase II complex ...