Browsing HMS Scholarly Articles by Author "Murugaiyan, Gopal"

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    • Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation 

      Mazzola, Maria Antonietta; Raheja, Radhika; Murugaiyan, Gopal; Rajabi, Hasan; Kumar, Deepak; Pertel, Thomas; Regev, Keren; Griffin, Russell; Aly, Lilian; Kivisakk, Pia; Nejad, Parham; Patel, Bonny; Gwanyalla, Nguendab; Hei, Hillary; Glanz, Bonnie; Chitnis, Tanuja; Weiner, Howard L.; Gandhi, Roopali (BioMed Central, 2015)
      Background: Fingolimod (FTY720), the first oral treatment for multiple sclerosis (MS), blocks immune cell trafficking and prevents disease relapses by downregulation of sphingosine-1-phosphate receptor. We determined the ...