Browsing HMS Scholarly Articles by Title

Now showing items 6261-6280 of 17922

    • Field Evaluation of a Prototype Paper-Based Point-of-Care Fingerstick Transaminase Test 

      Pollock, Nira R.; McGray, Sarah; Colby, Donn J.; Noubary, Farzad; Nguyen, Huyen; Nguyen, The Anh; Khormaee, Sariah; Jain, Sidhartha; Hawkins, Kenneth; Kumar, Shailendra; Rolland, Jason P.; Beattie, Patrick D.; Chau, Nguyen V.; Quang, Vo M.; Barfield, Cori; Tietje, Kathy; Steele, Matt; Weigl, Bernhard H. (Public Library of Science, 2013)
      Monitoring for drug-induced liver injury (DILI) via serial transaminase measurements in patients on potentially hepatotoxic medications (e.g., for HIV and tuberculosis) is routine in resource-rich nations, but often ...

    • Filamin A mediated Big2 dependent endocytosis: From apical abscission to periventricular heterotopia 

      Sheen, Volney L (Landes Bioscience, 2014)
      Periventricular heterotopia (PH) is one of the most common malformations of cortical development (MCD). Nodules along the lateral ventricles of the brain, disruption of the ventricular lining, and a reduced brain size are ...

    • Filamin B Regulates Chondrocyte Proliferation and Differentiation through Cdk1 Signaling 

      Hu, Jianjun; Lu, Jie; Lian, Gewei; Zhang, Jingping; Hecht, Jonathan L.; Sheen, Volney L. (Public Library of Science, 2014)
      Humans who harbor loss of function mutations in the actin-associated filamin B (FLNB) gene develop spondylocarpotarsal syndrome (SCT), a disorder characterized by dwarfism (delayed bone formation) and premature fusion of ...

    • Filamin-A Regulates Neutrophil Uropod Retraction through RhoA during Chemotaxis 

      Sun, Chunxiang; Forster, Carol; Nakamura, Fumihiko; Glogauer, Michael (Public Library of Science, 2013)
      Filamin-A (FLNa) has been shown to be a key cross-linker of actin filaments in the leading edge of a motile melanoma cell line, however its role in neutrophils undergoing chemotaxis is unknown. Using a murine transgenic ...

    • Filter Paper Blood Spot Enzyme Linked Immunoassay for Adiponectin and Application in the Evaluation of Determinants of Child Insulin Sensitivity 

      Martin, Richard M.; Patel, Rita; Oken, Emily; Thompson, Jennifer; Zinovik, Alexander; Kramer, Michael S.; Vilchuck, Konstantin; Bogdanovich, Natalia; Sergeichick, Natalia; Foo, Ying; Gusina, Nina (Public Library of Science, 2013)
      Background: Adiponectin is an adipocyte-derived hormone that acts as a marker of insulin sensitivity. Bloodspot sampling by fingerstick onto filter paper may increase the feasibility of large-scale studies of the determinants ...

    • Filter Paper Blood Spot Enzyme Linked Immunoassay for Insulin and Application in the Evaluation of Determinants of Child Insulin Resistance 

      Martin, Richard M.; Patel, Rita; Zinovik, Alexander; Kramer, Michael S.; Oken, Emily; Vilchuck, Konstantin; Bogdanovich, Natalia; Sergeichick, Natalia; Gunnarsson, Robert; Grufman, Lisa; Foo, Ying; Gusina, Nina (Public Library of Science, 2012)
      Background: In large-scale epidemiology, bloodspot sampling by fingerstick onto filter paper has many advantages, including ease and low costs of collection, processing and transport. We describe the development of an ...

    • A filtered approach to neural tractography using the Watson directional function 

      Malcolm, James G.; Michailovich, Oleg; Bouix, Sylvain; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Rathi, Yogesh (Elsevier BV, 2010)
      We propose a technique to simultaneously estimate the local fiber orientations and perform multifiber tractography. Existing techniques estimate the local fiber orientation at each voxel independently so there is no running ...

    • Filtered Multitensor Tractography 

      Malcolm, James G; Shenton, Martha Elizabeth; Rathi, Yogesh (Institute of Electrical & Electronics Engineers (IEEE), 2010)
      We describe a technique that uses tractography to drive the local fiber model estimation. Existing techniques use independent estimation at each voxel so there is no running knowledge of confidence in the estimated model ...

    • Financial contributions to global surgery: an analysis of 160 international charitable organizations 

      Gutnik, Lily; Yamey, Gavin; Riviello, Robert; Meara, John G.; Dare, Anna J.; Shrime, Mark G. (Springer International Publishing, 2016)
      Background: The non-profit and volunteer sector has made notable contributions to delivering surgical services in low-and middle-income countries (LMICs). As an estimated 55 % of surgical care delivered in some LMICs is ...

    • Finding New Order in Biological Functions from the Network Structure of Gene Annotations 

      Glass, Kimberly; Girvan, Michelle (Public Library of Science, 2015)
      The Gene Ontology (GO) provides biologists with a controlled terminology that describes how genes are associated with functions and how functional terms are related to one another. These term-term relationships encode how ...

    • Finding synchrony in the desynchronized EEG: the history and interpretation of gamma rhythms 

      Ahmed, Omar J.; Cash, Sydney S. (Frontiers Media S.A., 2013)
      Neocortical gamma (30–80 Hz) rhythms correlate with attention, movement and perception and are often disrupted in neurological and psychiatric disorders. Gamma primarily occurs during alert brain states characterized by ...

    • Finding the Best Thresholds of FEV1 and Dyspnea to Predict 5-Year Survival in COPD Patients: The COCOMICS Study 

      Almagro, Pere; Martinez-Camblor, Pablo; Soriano, Joan B.; Marin, Jose M.; Alfageme, Inmaculada; Casanova, Ciro; Esteban, Cristobal; Soler-Cataluña, Juan J.; de-Torres, Juan P.; Celli, Bartolome R.; Miravitlles, Marc (Public Library of Science, 2014)
      Background: FEV1 is universally used as a measure of severity in COPD. Current thresholds are based on expert opinion and not on evidence. Objectives: We aimed to identify the best FEV1 (% predicted) and dyspnea (mMRC) ...

    • Findings in Schizophrenia by Tract-Oriented DT-MRI Analysis 

      Maddah, Mahnaz; Kubicki, Marek R.; Wells, William Mercer; Westin, Carl-Fredrik; Shenton, Martha Elizabeth; Grimson, W. Eric L.; Grimson, Eric (Springer Science + Business Media, 2008)
      This paper presents a tract-oriented analysis of diffusion tensor (DT) images of the human brain. We demonstrate that unlike the commonly used ROI-based methods for population studies, our technique is sensitive to the ...

    • Fine Mapping of the GLC1K Juvenile Primary Open-Angle Glaucoma Locus and Exclusion of Candidate Genes 

      Sud, A.; Del Bono, E. A.; Haines, Jennifer; Wiggs, Janey Lee (Molecular Vision, 2008)
      Purpose: Primary open-angle glaucoma is a leading cause of blindness worldwide. We previously identified a region on chromosome 20p12 associated with juvenile-onset primary open-angle glaucoma (JOAG) that was designated ...

    • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers 

      Onengut-Gumuscu, Suna; Chen, Wei-Min; Burren, Oliver; Cooper, Nick J.; Quinlan, Aaron R.; Mychaleckyj, Josyf C.; Farber, Emily; Bonnie, Jessica K.; Szpak, Michal; Schofield, Ellen; Achuthan, Premanand; Guo, Hui; Fortune, Mary D.; Stevens, Helen; Walker, Neil M.; Ward, Luke D.; Kundaje, Anshul; Kellis, Manolis; Daly, Mark J.; Barrett, Jeffrey C.; Cooper, Jason D.; Deloukas, Panos; Todd, John A.; Wallace, Chris; Concannon, Patrick; Rich, Stephen S. (2015)
      Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions1,2 (www.T1DBase.org) revealing major pathways contributing to risk3, with some loci shared across immune disorders4–6. In order to make ...

    • Fine Mapping the \(KLK3\) Locus on Chromosome 19q13.33 Associated With Prostate Cancer Susceptibility and PSA Levels 

      Parikh, Hemang; Wang, Zhaoming; Pettigrew, Kerry A.; Jia, Jinping; Daugherty, Sarah; Yeager, Meredith; Jacobs, Kevin B.; Hutchinson, Amy; Burdett, Laura; Cullen, Michael; Qi, Liqun; Boland, Joseph; Collins, Irene; Albert, Thomas J.; Hveem, Kristian; Cancel-Tassin, Geraldine; Cussenot, Olivier; Valeri, Antoine; Virtamo, Jarmo; Thun, Michael J.; Feigelson, Heather Spencer; Diver, W. Ryan; Chatterjee, Nilanjan; Thomas, Gilles; Albanes, Demetrius; Chanock, Stephen J.; Hoover, Robert; Hayes, Richard B.; Berndt, Sonja I.; Sampson, Joshua; Amundadottir, Laufey; Vatten, Lars Johan; Hunter, David J.; Njølstad, Inger (Springer-Verlag, 2011)
      Measurements of serum prostate-specific antigen (PSA) protein levels form the basis for a widely used test to screen men for prostate cancer. Germline variants in the gene that encodes the PSA protein (\(KLK3\)) have been ...

    • Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment 

      Lizotte, Patrick H.; Jones, Robert E.; Keogh, Lauren; Ivanova, Elena; Liu, Hongye; Awad, Mark M.; Hammerman, Peter S.; Gill, Ritu R.; Richards, William G.; Barbie, David A.; Bass, Adam J.; Bueno, Raphael; English, Jessie M.; Bittinger, Mark; Wong, Kwok-Kin (Nature Publishing Group, 2016)
      With the emergence of checkpoint blockade and other immunotherapeutic drugs, and the growing adoption of smaller, more flexible adaptive clinical trial designs, there is an unmet need to develop diagnostics that can rapidly ...

    • Fine Structural Localization of Cholesterol-1,2-3h in Degenerating and Regenerating Mouse Sciatic Nerve 

      Rawlins, F. A.; Villegas, G. M.; Hedley-Whyte, E. Tessa; Uzman, B. G. (Rockefeller University Press, 1972)
      The localization of 3H-labeled cholesterol in nerves undergoing degeneration and regeneration was studied by radioautography at the electron microscope level. Two types of experiments were carried out: (a) Cholesterol-1,2-3H ...

    • Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2 

      Orr, Nick; Dudbridge, Frank; Dryden, Nicola; Maguire, Sarah; Novo, Daniela; Perrakis, Eleni; Johnson, Nichola; Ghoussaini, Maya; Hopper, John L.; Southey, Melissa C.; Apicella, Carmel; Stone, Jennifer; Schmidt, Marjanka K.; Broeks, Annegien; Van't Veer, Laura J.; Hogervorst, Frans B.; Fasching, Peter A.; Haeberle, Lothar; Ekici, Arif B.; Beckmann, Matthias W.; Gibson, Lorna; Aitken, Zoe; Warren, Helen; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Burwinkel, Barbara; Marme, Frederik; Schneeweiss, Andreas; Sohn, Chistof; Guénel, Pascal; Truong, Thérèse; Cordina-Duverger, Emilie; Sanchez, Marie; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Benitez, Javier; Zamora, Maria Pilar; Arias Perez, Jose Ignacio; Menéndez, Primitiva; Anton-Culver, Hoda; Neuhausen, Susan L.; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Hamann, Ute; Brauch, Hiltrud; Justenhoven, Christina; Brüning, Thomas; Ko, Yon-Dschun; Nevanlinna, Heli; Aittomäki, Kristiina; Blomqvist, Carl; Khan, Sofia; Bogdanova, Natalia; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Chenevix-Trench, Georgia; Beesley, Jonathan; Lambrechts, Diether; Moisse, Matthieu; Floris, Guiseppe; Beuselinck, Benoit; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Peissel, Bernard; Pensotti, Valeria; Couch, Fergus J.; Olson, Janet E.; Slettedahl, Seth; Vachon, Celine; Giles, Graham G.; Milne, Roger L.; McLean, Catriona; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Kristensen, Vessela; Alnæs, Grethe Grenaker; Nord, Silje; Borresen-Dale, Anne-Lise; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Tchatchou, Sandrine; Devilee, Peter; Tollenaar, Robertus A. E. M.; Seynaeve, Caroline M.; Van Asperen, Christi J.; Garcia-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Klevebring, Daniel; Hooning, Maartje J.; Hollestelle, Antoinette; van Deurzen, Carolien H. M.; Kriege, Mieke; Hall, Per; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Pharoah, Paul D. P.; Dunning, Alison M.; Shah, Mitul; Perkins, Barbara J.; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Ashworth, Alan; Swerdlow, Anthony; Jones, Michael; Schoemaker, Minouk J.; Meindl, Alfons; Schmutzler, Rita K.; Olswold, Curtis; Slager, Susan; Toland, Amanda E.; Yannoukakos, Drakoulis; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Matsuo, Keitaro; Ito, Hidema; Iwata, Hiroji; Ishiguro, Junko; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Teo, Soo Hwang; Yip, Cheng Har; Kang, Peter; Ikram, Mohammad Kamran; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Kang, Daehee; Choi, Ji-Yeob; Park, Sue K.; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Lim, Wei Yen; Lee, Soo Chin; Sangrajrang, Suleeporn; Gaborieau, Valerie; Brennan, Paul; Mckay, James; Wu, Pei-Ei; Hou, Ming-Feng; Yu, Jyh-Cherng; Shen, Chen-Yang; Blot, William; Cai, Qiuyin; Signorello, Lisa B.; Luccarini, Craig; Bayes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S.; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Hunter, David J.; Lindstrom, Sara; Dennis, Joe; Michailidou, Kyriaki; Bolla, Manjeet K.; Easton, Douglas F.; dos Santos Silva, Isabel; Fletcher, Olivia; Peto, Julian (Oxford University Press, 2015)
      We recently identified a novel susceptibility variant, rs865686, for estrogen-receptor positive breast cancer at 9q31.2. Here, we report a fine-mapping analysis of the 9q31.2 susceptibility locus using 43 160 cases and 42 ...

    • Fine-mapping in the MHC region accounts for 18% additional genetic risk for celiac disease 

      Gutierrez-Achury, Javier; Zhernakova, Alexandra; Pulit, Sara L.; Trynka, Gosia; Hunt, Karen A.; Romanos, Jihane; Raychaudhuri, Soumya; van Heel, David A.; Wijmenga, Cisca; de Bakker, Paul I.W. (2015)
      Although dietary gluten is the trigger, celiac disease risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine-mapped the MHC association signal to identify additional ...