Browsing HMS Scholarly Articles by Title
Now showing items 16269-16288 of 17928
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T Cell Activation Markers and African Mitochondrial DNA Haplogroups among Non-Hispanic Black Participants in AIDS Clinical Trials Group Study 384
(Public Library of Science, 2012)Introduction: Mitochondrial function influences T cell dynamics and is affected by mitochondrial DNA (mtDNA) variation. We previously reported an association between African mtDNA haplogroup L2 and less robust CD4 cell ... -
T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases
(Frontiers Research Foundation, 2012)A broad array of evidence indicates that T lymphocytes make significant contributions to vascular inflammation in the setting of atherosclerotic disease, hypertension, autoimmune vasculitis, and other disorders. Experimental ... -
T Cell Detection of a B-Cell Tropic Virus Infection: Newly-Synthesised versus Mature Viral Proteins as Antigen Sources for CD4 and CD8 Epitope Display
(Public Library of Science, 2009)Viruses that naturally infect cells expressing both MHC I and MHC II molecules render themselves potentially visible to both CD8+ and CD4+ T cells through the de novo expression of viral antigens. Here we use one such ... -
T cell receptor recognition of CD1b presenting a mycobacterial glycolipid
(Nature Publishing Group, 2016)CD1 proteins present microbial lipids to T cells. Germline-encoded mycolyl lipid-reactive (GEM) T cells with conserved αβ T cell receptors (TCRs) recognize CD1b presenting mycobacterial mycolates. As the molecular basis ... -
T Cell Transcriptomes Describe Patient Subtypes in Systemic Lupus Erythematosus
(Public Library of Science, 2015)Background: T cells regulate the adaptive immune response and have altered function in autoimmunity. Systemic Lupus Erythematosus (SLE) has great diversity of presentation and treatment response. Peripheral blood component ... -
T cell–derived inducible nitric oxide synthase switches off TH17 cell differentiation
(The Rockefeller University Press, 2013)RORγt is necessary for the generation of TH17 cells but the molecular mechanisms for the regulation of TH17 cells are still not fully understood. We show that activation of CD4+ T cells results in the expression of inducible ... -
T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice
(The Rockefeller University Press, 2014)T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell–derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, ... -
T granules in human platelets function in TLR9 organization and signaling
(The Rockefeller University Press, 2012)Human and murine platelets (PLTs) variably express toll-like receptors (TLRs), which link the innate and adaptive immune responses during infectious inflammation and atherosclerotic vascular disease. In this paper, we show ... -
T Lymphocyte–Endothelial Interactions: Emerging Understanding of Trafficking and Antigen-Specific Immunity
(Frontiers Media S.A., 2015)Antigen-specific immunity requires regulated trafficking of T cells in and out of diverse tissues in order to orchestrate lymphocyte development, immune surveillance, responses, and memory. The endothelium serves as a ... -
T-cell co-stimulatory blockade in kidney transplantation: back to the bench
(Nature Publishing Group, 2011)It is believed that blocking positive T-cell co-stimulatory pathways should lead to long-term graft acceptance. Despite the exciting initial achievements in experimental animal models, targeting co-stimulatory pathways has ... -
T-Cell Non-Hodgkin Lymphomas: Spectrum of Disease and the Role of Imaging in the Management of Common Subtypes
(The Korean Society of Radiology, 2017)T-cell non-Hodgkin lymphomas (NHLs) are biologically diverse, uncommon malignancies characterized by a spectrum of imaging findings according to subtype. The purpose of this review is to describe the common subtypes of ... -
T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy
(Springer Science and Business Media LLC, 2017-03-27)Advances in cancer immunotherapy have offered new hope for patients with metastatic disease. This unfolding success story has been exemplified by a growing arsenal of novel immunotherapeutics, including blocking antibodies ... -
T1- vs. T2-based MRI measures of spinal cord volume in healthy subjects and patients with multiple sclerosis
(BioMed Central, 2015)Background: The reliable and efficient measurement of spinal cord atrophy is of growing interest in monitoring disease progression in multiple sclerosis (MS). Methods: We compared T1- and T2-weighted MRI for measuring ... -
The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1
(Nature Publishing Group, 2016)A coding polymorphism of human ATG16L1 (rs2241880; T300A) increases the risk of Crohn's disease and it has been shown to enhance susceptibility of ATG16L1 to caspase cleavage. Here we show that T300A also alters the ability ... -
Tablet Keyboard Configuration Affects Performance, Discomfort and Task Difficulty for Thumb Typing in a Two-Handed Grip
(Public Library of Science, 2013)When holding a tablet computer with two hands, the touch keyboard configuration imposes postural constraints on the user because of the need to simultaneously hold the device and type with the thumbs. Designers have provided ... -
Tai Chi and Vestibular Rehabilitation Improve Vestibulopathic Gait via Different Neuromuscular Mechanisms: Preliminary Report
(BioMed Central, 2005)Background: Vestibular rehabilitation (VR) is a well-accepted exercise program intended to remedy balance impairment caused by damage to the peripheral vestibular system. Alternative therapies, such as Tai Chi (TC), have ... -
Tai Chi for Osteopenic Women: Design and Rationale of a Pragmatic Randomized Controlled Trial
(BioMed Central, 2010)Background: Post-menopausal osteopenic women are at increased risk for skeletal fractures. Current osteopenia treatment guidelines include exercise, however, optimal exercise regimens for attenuating bone mineral density ... -
Tai chi mind-body exercise in patients with COPD: study protocol for a randomized controlled trial
(BioMed Central, 2014)Background: Chronic obstructive pulmonary disease (COPD) is a chronic, progressively debilitating condition that is prevalent in the US and worldwide. Patients suffer from progressive dyspnea and exercise intolerance. ... -
Tai Chi Training may Reduce Dual Task Gait Variability, a Potential Mediator of Fall Risk, in Healthy Older Adults: Cross-Sectional and Randomized Trial Studies
(Frontiers Media S.A., 2015)Background: Tai Chi (TC) exercise improves balance and reduces falls in older, health-impaired adults. TC’s impact on dual task (DT) gait parameters predictive of falls, especially in healthy active older adults, however, ...