Browsing HMS Scholarly Articles by Title

Now showing items 2196-2215 of 17922

    • Causes of Death on Antiretroviral Therapy: A Post-Mortem Study from South Africa 

      Wong, Emily Beth; Omar, Tanvier; Setlhako, Gosetsemang J.; Osih, Regina; Feldman, Charles; Murdoch, David M.; Martinson, Neil A.; Bangsberg, David Roy; Venter, W. D. F. (Public Library of Science, 2012)
      Background: Mortality in the first months of antiretroviral therapy (ART) is a significant clinical problem in sub-Saharan Africa. To date, no post-mortem study has investigated the causes of mortality in these patients. ...

    • Causes of Maternal and Child Mortality Among Cambodian Sex Workers and Their Children: A Cross Sectional Study 

      Willis, Brian; Onda, Saki; Stoklosa, Hanni (BMC, 2016-11-21)
      Background: To reach global and national goals for maternal and child mortality, countries must identify vulnerable populations, which includes sex workers and their children. The objective of this study was to identify ...

    • The cavefish genome reveals candidate genes for eye loss 

      McGaugh, Suzanne E.; Gross, Joshua B.; Aken, Bronwen; Blin, Maryline; Borowsky, Richard; Chalopin, Domitille; Hinaux, Hélène; Jeffery, William R.; Keene, Alex; Ma, Li; Minx, Patrick; Murphy, Daniel; O’Quin, Kelly E.; Rétaux, Sylvie; Rohner, Nicolas; Searle, Steve M. J.; Stahl, Bethany A.; Tabin, Cliff; Volff, Jean-Nicolas; Yoshizawa, Masato; Warren, Wesley C. (Nature Pub. Group, 2014)
      Natural populations subjected to strong environmental selection pressures offer a window into the genetic underpinnings of evolutionary change. Cavefish populations, Astyanax mexicanus (Teleostei: Characiphysi), exhibit ...

    • Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis 

      Baudrand, Rene; Gupta, Nidhi; Garza, Amanda E.; Vaidya, Anand; Leopold, Jane A.; Hopkins, Paul N.; Jeunemaitre, Xavier; Ferri, Claudio; Romero, Jose R.; Williams, Jonathan; Loscalzo, Joseph; Adler, Gail K.; Williams, Gordon H.; Pojoga, Luminita H. (John Wiley and Sons Inc., 2016)
      Background: Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR ...

    • Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells 

      Yousuf, Mohammad A.; Zhou, Xiaohong; Mukherjee, Santanu; Chintakuntlawar, Ashish V.; Lee, Jeong Yoon; Ramke, Mirja; Chodosh, James; Rajaiya, Jaya (Public Library of Science, 2013)
      The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection. Epidemic keratoconjunctivitis ...

    • Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2) 

      Li, W.; Liu, H.; Zhou, J.-S.; Cao, J.-F.; Zhou, Xiaobo; Choi, A. M. K.; Chen, Z.-H.; Shen, H.-H. (American Society for Biochemistry & Molecular Biology (ASBMB), 2012)
      The Nrf2 (nuclear erythroid 2 p45-related factor-2) signaling pathway is known to play a pivotal role in a variety of oxidative stress-related human disorders. It has been reported recently that the plasma membrane resident ...

    • Caveolin-1 Is a Critical Determinant of Autophagy, Metabolic Switching, and Oxidative Stress in Vascular Endothelium 

      Shiroto, Takashi; Romero, Natalia; Sugiyama, Toru; Sartoretto, Juliano L.; Kalwa, Hermann; Yan, Zhonghua; Shimokawa, Hiroaki; Michel, Thomas (Public Library of Science, 2014)
      Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1null mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood. ...

    • Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study 

      Kasai, Kiyoto; McCarley, Robert William; Salisbury, Dean F.; Onitsuka, Toshiaki; Demeo, Susan; Yurgelun-Todd, Deborah; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (Elsevier BV, 2004)
      A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical ...

    • Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder 

      May, Flavia S; Chen, Q.Cece; Gilbertson, Mark; Shenton, Martha Elizabeth; Pitman, roger Keith (Elsevier BV, 2004)
      Background Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain. Methods: We utilized magnetic resonance imaging to measure ...

    • CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases 

      Tan, Yi-Hung Carol; Krishnaswamy, Soundararajan; Nandi, Suvobroto; Kanteti, Rajani; Vora, Sapana; Onel, Kenan; Hasina, Rifat; Lo, Fang-Yi; El-Hashani, Essam; Cervantes, Gustavo; Lipkowitz, Stanley; Karrison, Theodore; Vokes, Everett E.; Wang, Yi-Ching; Salgia, Ravi; Najbauer, Joseph; Robinson, Matthew; Kales, Stephen C.; Sattler, Martin (Public Library of Science, 2010)
      Background: Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis ...

    • CC2D1A Regulates Human Intellectual and Social Function as well as NF-κB Signaling Homeostasis 

      Manzini, M. Chiara; Xiong, Lan; Shaheen, Ranad; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Ghaziuddin, Mohammed; Christian, Mehtab; Jiang, Qin; Laurent, Sandra; Nanjiani, Zohair A.; Rasheed, Saima; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Salih, Mustafa A.; Alkuraya, Fowzan S.; Walsh, Christopher A. (2015)
      SUMMARY Autism spectrum disorder (ASD) and intellectual disability (ID) are often comorbid, but the extent to which they share common genetic causes remains controversial. Here, we present two autosomal-recessive “founder” ...

    • CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma 

      Cai, Yi; Hirata, Ayako; Nakayama, Sohei; VanderLaan, Paul A.; Levantini, Elena; Yamamoto, Mihoko; Hirai, Hideyo; Wong, Kwok-Kin; Costa, Daniel B.; Watanabe, Hideo; Kobayashi, Susumu S. (Public Library of Science, 2015)
      Lung cancer is the leading cause of cancer death worldwide. Although disruption of normal proliferation and differentiation is a vital component of tumorigenesis, the mechanisms of this process in lung cancer are still ...

    • CCAAT/Enhancer-Binding Protein \(\gamma\) Is a Critical Regulator of IL-1\(\beta\)-Induced IL-6 Production in Alveolar Epithelial Cells 

      Yan, Chunguang; Wang, Ximo; Cao, Jay; Wu, Min; Gao, Hongwei (Public Library of Science, 2012)
      CCAAT/enhancer binding protein \(\gamma\) (C/EBPγ) is a member of the C/EBP family of transcription factors, which lacks known activation domains. C/EBP\(\gamma\) was originally described as an inhibitor of C/EBP transactivation ...

    • CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model 

      Scaiewicz, Viviana; Nahmias, Avital; Chung, Raymond T.; Mueller, Tobias; Tirosh, Boaz; Shibolet, Oren (Public Library of Science, 2013)
      Background and Aims C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism. ...

    • Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53 

      Sorrells, Shelly; Carbonneau, Seth; Harrington, Erik; Chen, Aye T.; Hast, Bridgid; Milash, Brett; Major, Michael B.; Stewart, Rodney A.; Jette, Cicely; Pyati, Ujwal Jagdeesh; Zon, Leonard Ira; Look, A. Thomas; Zhou, Yi (Public Library of Science, 2012)
      DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought ...

    • CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue 

      Chauhan, Sunil Kumar; Saban, Daniel R.; Dohlman, Thomas H.; Dana, Reza (The American Association of Immunologists, 2013)
      Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with antigen-presenting cells (APC) and T cells, interactions ...

    • CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function 

      Chun, Eunyoung; Lavoie, Sydney; Michaud, Monia; Gallini, Carey Ann; Kim, Jason; Soucy, Genevieve; Odze, Robert; Glickman, Jonathan N.; Garrett, Wendy S. (2015)
      Summary Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that ...

    • CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice 

      Chen, Xuguang; Wang, Yunyue; Nelson, David; Tian, Sara; Mulvey, Erin; Patel, Bhumi; Conti, Ilaria; Jaen, Juan; Rollins, Barrett J. (Public Library of Science, 2016)
      Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report ...

    • CCN1 Secretion Induced by Cigarette Smoking Extracts Augments IL-8 Release from Bronchial Epithelial Cells 

      Moon, Hyung-Geun; Zheng, Yijie; An, Chang Hyeok; Kim, Yoon-Keun; Jin, Yang (Public Library of Science, 2013)
      Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS ...

    • CCR5 Chemokine Receptor Mediates Recruitment of MHC Class II-Positive Langerhans Cells in the Mouse Corneal Epithelium 

      Yamagami, Satoru; Hamrah, Pedram; Miyamoto, Kazuhisa; Miyazaki, Dai; Dekaris, Iva; Dawson, Tracey; Lu, Bao; Gerard, Craig; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2005)
      purpose. To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-α, on the recruitment of MHC class II+ Langerhans ...