Browsing HMS Scholarly Articles by Title

Now showing items 269-288 of 17922

    • Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme 

      Jun, Hyun Jung; Acquaviva, Jaime; Chi, Dorcas; Lessard, Julie; Zhu, Haihao; Woolfenden, Steve; Bronson, Roderick T.; Pfannl, Rolf; White, Forest; Housman, David E.; Iyer, Lakshmanan; Whittaker, Charles A.; Boskovitz, Abraham; Raval, Ami; Charest, Alain (2013)
      Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. ...

    • Across-cohort QC analyses of GWAS summary statistics from complex traits 

      Chen, Guo-Bo; Lee, Sang Hong; Robinson, Matthew R; Trzaskowski, Maciej; Zhu, Zhi-Xiang; Winkler, Thomas W; Day, Felix R; Croteau-Chonka, Damien C; Wood, Andrew R; Locke, Adam E; Kutalik, Zoltán; Loos, Ruth J F; Frayling, Timothy M; Hirschhorn, Joel N; Yang, Jian; Wray, Naomi R; Visscher, Peter M (Nature Publishing Group, 2017)
      Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires ...

    • Actin Binding Domains Direct Actin-Binding Proteins to Different Cytoskeletal Locations 

      Washington, Raymond William; Knecht, David A (BioMed Central, 2008)
      Background: Filamin (FLN) and non-muscle α-actinin are members of a family of F-actin cross-linking proteins that utilize Calponin Homology domains (CH-domain) for actin binding. Although these two proteins have been ...

    • Actin Disassembly by Cofilin, Coronin, and Aip1 Occurs in Bursts and Is Inhibited by Barbed-end Cappers 

      Kueh, Hao Yuan; Charras, Guillaume T.; Mitchison, Timothy J.; Brieher, William M. (The Rockefeller University Press, 2008)
      Turnover of actin filaments in cells requires rapid actin disassembly in a cytoplasmic environment that thermodynamically favors assembly because of high concentrations of polymerizable monomers. We here image the disassembly ...

    • Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway 

      Kumari, Sudha; Depoil, David; Martinelli, Roberta; Judokusumo, Edward; Carmona, Guillaume; Gertler, Frank B; Kam, Lance C; Carman, Christopher V; Burkhardt, Janis K; Irvine, Darrell J; Dustin, Michael L (eLife Sciences Publications, Ltd, 2015)
      Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway ...

    • Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion 

      Rullo, Jacob; Becker, Henry; Hyduk, Sharon J.; Wong, Janice C.; Digby, Genevieve; Arora, Pamma D.; Cano, Adrianet Puig; Hartwig, John Henry; McCulloch, Christopher A.; Cybulsky, Myron I. (The Rockefeller University Press, 2012)
      Leukocytes arrested on inflamed endothelium via integrins are subjected to force imparted by flowing blood. How leukocytes respond to this force and resist detachment is poorly understood. Live-cell imaging with ...

    • An Actin-Based Wave Generator Organizes Cell Motility 

      Weiner, Orion D; Marganski, William A; Wu, Lani F; Altschuler, Steven J; Kirschner, Marc W. (Public Library of Science, 2007)
      Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the spatial dynamics of a key ...

    • Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function 

      Pacak, Christina A.; Preble, Janine M.; Kondo, Hiroshi; Seibel, Peter; Levitsky, Sidney; del Nido, Pedro J.; Cowan, Douglas B.; McCully, James D. (The Company of Biologists, 2015)
      Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by ...

    • Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery: A Clinical Report and Literature Review 

      Hong, Jiaxu; Xu, Jianjiang; Cao, Wenjun; Ji, Jian; Sun, Xinghuai (Wolters Kluwer Health, 2016)
      Abstract Actinobacillus actinomycetemcomitans infection is a rare and easily misdiagnosed ocular disease. In this article, the authors report a chronic, purulent, and difficult-to-treat case of A actinomycetemcomitans ...

    • Action Initiation in the Human Dorsal Anterior Cingulate Cortex 

      Srinivasan, Lakshminarayan; Asaad, Wael F.; Ginat, Daniel T; Gale, John T.; Dougherty, Darin Dean; Williams, Ziv; Sejnowski, Terrence J.; Eskandar, Emad (Public Library of Science, 2013)
      The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC to the temporal onset of ...

    • Action video game play and transfer of navigation and spatial cognition skills in adolescents who are blind 

      Connors, Erin C.; Chrastil, Elizabeth R.; Sánchez, Jaime; Merabet, Lotfi B. (Frontiers Media S.A., 2014)
      For individuals who are blind, navigating independently in an unfamiliar environment represents a considerable challenge. Inspired by the rising popularity of video games, we have developed a novel approach to train ...

    • Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19 

      Gaziano, Liam; Giambartolomei, Claudia; Pereira, Alexandre C.; Gaulton, Anna; Posner, Daniel C.; Swanson, Sonja A.; Ho, Yuk-Lam; Iyengar, Sudha K.; Kosik, Nicole M.; Vujkovic, Marijana; Gagnon, David R.; Bento, A. Patrícia; Barrio-Hernandez, Inigo; Rönnblom, Lars; Hagberg, Niklas; Lundtoft, Christian; Langenberg, Claudia; Pietzner, Maik; Valentine, Dennis; Gustincich, Stefano; Tartaglia, Gian Gaetano; Allara, Elias; Surendran, Praveen; Burgess, Stephen; Zhao, Jing Hua; Peters, James E.; Prins, Bram P.; Angelantonio, Emanuele Di; Devineni, Poornima; Shi, Yunling; Lynch, Kristine E.; DuVall, Scott L.; Garcon, Helene; Thomann, Lauren O.; Zhou, Jin J.; Gorman, Bryan R.; Huffman, Jennifer E.; O’Donnell, Christopher J.; Tsao, Philip S.; Beckham, Jean C.; Pyarajan, Saiju; Muralidhar, Sumitra; Huang, Grant D.; Ramoni, Rachel; Beltrao, Pedro; Danesh, John; Hung, Adriana M.; Chang, Kyong-Mi; Sun, Yan V.; Joseph, Jacob; Leach, Andrew R.; Edwards, Todd L.; Cho, Kelly; Gaziano, J. Michael; Butterworth, Adam S.; Casas, Juan P.; Casas (Springer Science and Business Media LLC, 2021-04)

    • Activated carbon for aerobic oxidation: Benign approach toward 2-benzoylbenzimidazoles and 2-benzoylbenzoxazoles synthesis 

      Bao, Kai; Li, Fuqing; Liu, Hanjing; Wang, Zhiwei; Shen, Qirong; Wang, Jian; Zhang, Weige (Nature Publishing Group, 2015)
      A general strategy involving a novel and highly efficient aerobic benzylic oxidation promoted by cheap, reusable activated carbon in water is developed. Application of this method has been demonstrated in the benign synthesis ...

    • Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms 

      Schneider, Rebekka K; Ziegler, Susanne; Leisten, Isabelle; Ferreira, Monica SV; Schumacher, Anne; Rath, Björn; Fahrenkamp, Dirk; Müller-Newen, Gerhard; Crysandt, Martina; Wilop, Stefan; Jost, Edgar; Koschmieder, Steffen; Knüchel, Ruth; Brümmendorf, Tim H; Ziegler, Patrick (BioMed Central, 2014)
      We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units of normal ...

    • Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling 

      Beynon, Vanessa; Quintana, Francisco Javier; Weiner, Howard Lee (Public Library of Science, 2012)
      Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1β. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in ...

    • Activated mouse \(CD4^+Foxp3^−\) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity 

      Wang, Xiaojuan; Cui, Yanyan; Luo, Gaoxing; Wang, Qinghong; Hu, Jie; He, Weifeng; Yuan, Jun; Zhou, Junyi; Wu, Yan; Sun, Xiaofeng; Robson, Simon C; Li, Xianchang; Tan, Jiangling; Peng, Yanmeng; Xue, Gang; Lu, Linrong; Gao, Wenda; Wu, Jun (Nature Publishing Group, 2012)
      The regulatory activities of mouse \(CD^4+Foxp3^+\) T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional \(CD4^+Foxp3^−\) T cells in the periphery are able to ...

    • Activated N-Ras signaling regulates arterial-venous specification in zebrafish 

      Ren, Chun-Guang; Wang, Lei; Jia, Xiao-E; Liu, Yi-Jie; Dong, Zhi-Wei; Jin, Yi; Chen, Yi; Deng, Min; Zhou, Yong; Zhou, Yi; Ren, Rui-Bao; Pan, Wei-Jun; Liu, Ting-Xi (BioMed Central, 2013)
      Background: The aberrant activation of Ras signaling is associated with human diseases including hematological malignancies and vascular disorders. So far the pathological roles of activated Ras signaling in hematopoiesis ...

    • Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium 

      Zhang, Lifang; Wang, Dan; Jiang, Wei; Edwards, Dale; Qiu, Weiliang; Barroilhet, Lisa M; Rho, Jung-hyun; Jin, Lianjin; Seethappan, Vanitha; Vitonis, Allison; Wang, Jianliu; Mok, Samuel C; Crum, Christopher Paul; Cramer, Daniel William; Ye, Bin (Springer Science + Business Media, 2010)
      Objectives It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular ...

    • Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies 

      Bulliard, Yannick; Jolicoeur, Rose; Windman, Maurice; Rue, Sarah M.; Ettenberg, Seth; Knee, Deborah A.; Wilson, Nicholas S.; Dranoff, Glenn; Brogdon, Jennifer L. (The Rockefeller University Press, 2013)
      Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown ...

    • Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment 

      Herter-Sprie, Grit S.; Greulich, Heidi E.; Wong, Kwok-Kin (Frontiers Media S.A., 2013)
      Despite the ongoing “war on cancer,” cancer remains one of the major causes of human morbidity and mortality. A new paradigm of targeted therapies holds the most promise for the future, making identification of tumor-specific ...