Browsing HMS Scholarly Articles by Title
Now showing items 6728-6747 of 17922
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A general semi-parametric approach to the analysis of genetic association studies in population-based designs
(BioMed Central, 2013)Background: For genetic association studies in designs of unrelated individuals, current statistical methodology typically models the phenotype of interest as a function of the genotype and assumes a known statistical model ... -
General Strategy for Decoration of Enveloped Viruses with Functionally Active Lipid-Modified Cytokines
(American Society for Microbiology, 2007)Viral particles preferentially incorporate extra- and intracellular constituents of host cell lipid rafts, a phenomenon central to pseudotyping. Based on this mechanism, we have developed a system for the predictable ... -
A general strategy to construct small molecule biosensors in eukaryotes
(eLife Sciences Publications, Ltd, 2015)Biosensors for small molecules can be used in applications that range from metabolic engineering to orthogonal control of transcription. Here, we produce biosensors based on a ligand-binding domain (LBD) by using a method ... -
Generalization of adiposity genetic loci to US Hispanic women
(Nature Publishing Group, 2013)BACKGROUND: Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which is the largest US minority group, remains largely unknown. OBJECTIVE: ... -
The Generalized Discrimination of Facial Expressions by Seven-Month-Old Infants
(Wiley, 1985)2 experiments were conducted to examine 7-month-old infants' perception of the facial expressions happy and fear. Using a paired-comparison procedure, infants in the first experiment were able to generalize their discrimination ... -
Generalized Multiscale Entropy Analysis: Application to Quantifying the Complex Volatility of Human Heartbeat Time Series
(2016)We introduce a generalization of multiscale entropy (MSE) analysis. The method is termed MSEn, where the subscript denotes the moment used to coarse-grain a time series. MSEμ, described previously, uses the mean value ... -
Generating extracellular amyloid aggregates using E. coli cells
(Cold Spring Harbor Laboratory Press, 2012)Diverse proteins are known to be capable of forming amyloid aggregates, self-seeding fibrillar assemblies that may be biologically functional or pathological. Well-known examples include neurodegenerative disease-associated ... -
Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
(Springer Science and Business Media LLC, 2022-03-23)Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator, and stimuli sensor. The large-scale generation of human skin with these appendages would ... -
Generation and Regulation of CD8+ Regulatory T Cells
(Nature Publishing Group, 2008)Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been ... -
Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly
(eLife Sciences Publications, Ltd, 2015)Adhesion and morphogenesis of many non-muscle cells are guided by contractile actomyosin bundles called ventral stress fibers. While it is well established that stress fibers are mechanosensitive structures, physical ... -
Generation of kidney tubular organoids from human pluripotent stem cells
(Nature Publishing Group, 2016)Recent advances in stem cell research have resulted in methods to generate kidney organoids from human pluripotent stem cells (hPSCs), which contain cells of multiple lineages including nephron epithelial cells. Methods ... -
Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity
(American Society for Microbiology, 2016)ABSTRACT An effective preventive vaccine is highly sought after in order to stem the current HIV-1 pandemic. Both conservation of contiguous gp41 membrane-proximal external region (MPER) amino acid sequences across HIV-1 ... -
Generation of Mice with a Conditional Foxp2 Null Allele
(Wiley-Blackwell, 2007)Disruptions of the human FOXP2 gene cause problems with articulation of complex speech sounds, accompanied by impairment in many aspects of language ability. The FOXP2/Foxp2 transcription factor is highly similar in humans ... -
Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing
(2014)Genome sequencing studies have shown that human malignancies often bear mutations in four or more driver genes1, but it is difficult to recapitulate this degree of genetic complexity in mouse models using conventional ... -
Generation of nonidentical compartments in vesicular transport systems
(Rockefeller University Press, 2005)How can organelles communicate by bidirectional vesicle transport and yet maintain different protein compositions? We show by mathematical modeling that a minimal system, in which the basic variables are cytosolic coats ... -
Generation of stem cell-derived β-cells from patients with type 1 diabetes
(Nature Publishing Group, 2016)We recently reported the scalable in vitro production of functional stem cell-derived β-cells (SC-β cells). Here we extend this approach to generate the first SC-β cells from type 1 diabetic patients (T1D). β-cells are ... -
Generational influence on patient learning preferences in dermatology
(Elsevier BV, 2018) -
Genes and Environment in Multiple Sclerosis Project: A Platform to Investigate Multiple Sclerosis Risk
(Wiley, 2016-02)The Genes and Environment in Multiple Sclerosis (GEMS) project establishes a platform to investigate the events leading to MS in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using ... -
Genes Associated with Prognosis after Surgery for Malignant Pleural Mesothelioma Promote Tumor Cell Survival In Vitro
(BioMed Central, 2011)Background: Mesothelioma is an aggressive neoplasm with few effective treatments, one being cytoreductive surgery. We previously described a test, based on differential expression levels of four genes, to predict clinical ... -
Genes Contributing to Staphylococcus aureus Fitness in Abscess- and Infection-Related Ecologies
(American Society of Microbiology, 2014)ABSTRACT Staphylococcus aureus is a leading cause of both community- and hospital-acquired infections that are increasingly antibiotic resistant. The emergence of S. aureus resistance to even last-line antibiotics heightens ...