Browsing HMS Scholarly Articles by Title
Now showing items 8098-8117 of 17922
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Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
(American Association for the Advancement of Science, 2015)The tuberous sclerosis complex (TSC) family of tumor suppressors, TSC1 and TSC2, function together in an evolutionarily conserved protein complex that is a point of convergence for major cell signaling pathways that regulate ... -
The Identification of Prognostic Factors and Survival Statistics of Conventional Central Chondrosarcoma
(Hindawi Publishing Corporation, 2015)Introduction:. Chondrosarcomas are malignant bone tumors that are characterized by the production of chondroid tissue. Since radiation therapy and chemotherapy have limited effect on chondrosarcoma, treatment of most ... -
Identification of Protective Pneumococcal \(T_{H}17\) Antigens from the Soluble Fraction of a Killed Whole Cell Vaccine
(Public Library of Science, 2012)Mucosal or parenteral immunization with a killed unencapsulated pneumococcal whole cell antigen (WCA) with an adjuvant protects mice from colonization by a \(T_{H}17\) CD4+ cell-mediated mechanism. Using preparative SDS ... -
Identification of proteins found to be significantly altered when comparing the serum proteome from Multiple Myeloma patients with varying degrees of bone disease
(BioMed Central, 2014)Background: Bone destruction is a feature of multiple myeloma, characterised by osteolytic bone destruction due to increased osteoclast activity and suppressed or absent osteoblast activity. Almost all multiple myeloma ... -
Identification of Proteins Likely to Be Involved in Morphogenesis, Cell Division, and Signal Transduction in Planctomycetes by Comparative Genomics
(American Society for Microbiology, 2012)Members of the Planctomycetes clade share many unusual features for bacteria. Their cytoplasm contains membrane-bound compartments, they lack peptidoglycan and FtsZ, they divide by polar budding, and they are capable of ... -
Identification of proteomic biomarkers predicting prostate cancer aggressiveness and lethality despite biopsy-sampling error
(Nature Publishing Group, 2014)Background: Key challenges of biopsy-based determination of prostate cancer aggressiveness include tumour heterogeneity, biopsy-sampling error, and variations in biopsy interpretation. The resulting uncertainty in risk ... -
Identification of Pseudomonas aeruginosa Phenazines that Kill Caenorhabditis elegans
(Public Library of Science, 2013)Pathogenic microbes employ a variety of methods to overcome host defenses, including the production and dispersal of molecules that are toxic to their hosts. Pseudomonas aeruginosa, a Gram-negative bacterium, is a pathogen ... -
Identification of Raf-1 S471 as a Novel Phosphorylation Site Critical for Raf-1 and B-Raf Kinase Activities and for MEK Binding
(American Society for Cell Biology, 2005)The Ras-Raf-MAPK cascade is a key growth-signaling pathway and its uncontrolled activation results in cell transformation. Although the general features of the signal transmission along the cascade are reasonably defined, ... -
Identification of rare germline copy number variations over-represented in five human cancer types
(BioMed Central, 2015)Background: Copy number variations (CNVs) are increasingly recognized as significant disease susceptibility markers in many complex disorders including cancer. The availability of a large number of chromosomal copy number ... -
Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function
(American Society for Microbiology, 2016)ABSTRACT The surface of most Gram-negative bacteria is covered with lipopolysaccharide (LPS), creating a permeability barrier against toxic molecules, including many antimicrobials. To assemble LPS on their surface, ... -
Identification of resolvin D2 receptor mediating resolution of infections and organ protection
(The Rockefeller University Press, 2015)Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in host defense and the return to homeostasis. Resolvin (Rv)D2 is a potent immunoresolvent biosynthesized during active resolution that ... -
Identification of ROCK1 kinase as a critical regulator of Beclin1 mediated autophagy during metabolic stress
(2013)The Ser/Thr Rho kinase 1 (ROCK1) is known to play major roles in a wide range of cellular activities, including those involved in tumor metastasis and apoptosis. Here we identify an indispensable function of ROCK1 in ... -
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
(2013)Somatic chromosomal deletions in cancer are thought to indicate the location of tumor suppressor genes, whereby complete loss of gene function occurs through biallelic deletion, point mutation, or epigenetic silencing, ... -
Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks
(National Academy of Sciences, 2016)The cellular response to DNA damage during S-phase regulates a complicated network of processes, including cell-cycle progression, gene expression, DNA replication kinetics, and DNA repair. In fission yeast, this S-phase ... -
Identification of serum endoglin as a novel prognostic marker after acute myocardial infarction
(Blackwell Publishing Ltd, 2008)Abstract Endoglin is a proliferation-associated and hypoxia-inducible protein expressed in endothelial cells. The levels of soluble circulating endoglin and their prognostic significance in patients with acute myocardial ... -
Identification of Small Molecule Inhibitors of Neurite Loss Induced by Aβ peptide using High Content Screening
(American Society for Biochemistry and Molecular Biology, 2012) -
Identification of Small Molecule Inhibitors of Pseudomonas aeruginosa Exoenzyme S Using a Yeast Phenotypic Screen
(Public Library of Science, 2008)Pseudomonas aeruginosa is an opportunistic human pathogen that is a key factor in the mortality of cystic fibrosis patients, and infection represents an increased threat for human health worldwide. Because resistance of ... -
Identification of small molecules for human hepatocyte expansion and iPS differentiation
(2013)Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...