Browsing HMS Scholarly Articles by Title

Now showing items 9259-9278 of 17922

    • Investigation of Founder Effects for the Thr377Met Myocilin Mutation in Glaucoma Families from Differing Ethnic Backgrounds 

      Hewitt, Alex W.; Samples, John R.; Allingham, R. Rand; Järvelä, Irma; Kitsos, George; Krishnadas, Subbaiah R.; Richards, Julia E.; Lichter, Paul R.; Petersen, Michael B.; Sundaresan, Periasamy; Mackey, David A.; Wirtz, Mary K.; Wiggs, Janey Lee (Molecular Vision, 2007)
      Purpose: The aim of this study was to determine if there is a common founder for the Thr377Met myocilin mutation in primary open angle glaucoma (POAG) families with various ethnic backgrounds. Methods: Genomic DNA of 24 ...

    • Investigation of Genetic Variation Underlying Central Obesity amongst South Asians 

      Scott, William R.; Zhang, Weihua; Loh, Marie; Tan, Sian-Tsung; Lehne, Benjamin; Afzal, Uzma; Peralta, Juan; Saxena, Richa; Ralhan, Sarju; Wander, Gurpreet S.; Bozaoglu, Kiymet; Sanghera, Dharambir K.; Elliott, Paul; Scott, James; Chambers, John C.; Kooner, Jaspal S. (Public Library of Science, 2016)
      South Asians are 1/4 of the world’s population and have increased susceptibility to central obesity and related cardiometabolic disease. Knowledge of genetic variants affecting risk of central obesity is largely based on ...

    • Investigation of KIF6 Trp719Arg in a Case-Control Study of Myocardial Infarction: A Costa Rican Population 

      Bare, Lance A.; Ruiz-Narvaéz, Edward A.; Tong, Carmen H.; Arellano, Andre R.; Rowland, Charles M.; Catanese, Joseph J.; Sacks, Frank Martin; Devlin, James J.; Campos, Hannia (Public Library of Science (PLoS), 2010)
      Background and Methodology The 719Arg allele of KIF6 (rs20455) was associated with coronary events in Caucasian participants of five prospective studies. We investigated whether this KIF6 variant was associated with ...

    • Investigation of Transmembrane Proteins Using a Computational Approach 

      Yang, Jack Y; Yang, Mary Qu; Dunker, A Keith; Deng, Youping; Huang, Xudong (BioMed Central, 2008)
      Background: An important subfamily of membrane proteins are the transmembrane α-helical proteins, in which the membrane-spanning regions are made up of α-helices. Given the obvious biological and medical significance of ...

    • Investment in HIV/AIDS programs: Does it help strengthen health systems in developing countries? 

      Yu, Dongbao; Souteyrand, Yves; Banda, Mazuwa A; Kaufman, Joan A.; Perriëns, Joseph H (BioMed Central, 2008)
      Background: There is increasing debate about whether the scaled-up investment in HIV/AIDS programs is strengthening or weakening the fragile health systems of many developing countries. This article examines and assesses ...

    • Involvement of Arabidopsis RACK1 in Protein Translation and Its Regulation by Abscisic Acid 

      Guo, Jianjun; Wang, Shuqi; Valerius, Oliver; Hall, Hardy; Zeng, Qingning; Li, Jian-Feng; Weston, David J.; Ellis, Brian E.; Chen, Jin-Gui (American Society of Plant Biologists, 2010)
      Earlier studies have shown that RACK1 functions as a negative regulator of abscisic acid (ABA) responses in Arabidopsis (Arabidopsis thaliana), but the molecular mechanism of the action of RACK1 in these processes remains ...

    • Involvement of Corneal Lymphangiogenesis in a Mouse Model of Allergic Eye Disease 

      Lee, Hyun-Soo; Hos, Deniz; Blanco, Tomas; Bock, Felix; Reyes, Nancy J.; Mathew, Rose; Cursiefen, Claus; Dana, Reza; Saban, Daniel R. (Association for Research in Vision and Ophthalmology (ARVO), 2015)
      Purpose. The contribution of lymphangiogenesis (LA) to allergy has received considerable attention and therapeutic inhibition of this process via targeting VEGF has been considered. Likewise, certain inflammatory settings ...

    • Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells 

      Kim, Mi-Kyoung; Park, Hyun-Joo; Kim, Su-Ryun; Choi, Yoon Kyung; Bae, Soo-Kyung; Bae, Moon-Kyoung (The Korean Physiological Society and The Korean Society of Pharmacology, 2015)
      The cytoprotective enzyme heme oxygenase-1 (HO-1) influences endothelial cell survival, proliferation, inflammatory response, and angiogenesis in response to various angiogenic stimuli. In this study, we investigate the ...

    • Involvement of low- and middle-income countries in randomized controlled trial publications in oncology 

      Wong, Janice C; Fernandes, Kimberly A; Amin, Shubarna; Lwin, Zarnie; Krzyzanowska, Monika K (BioMed Central, 2014)
      Background: We describe trends in participation by investigators from low- and middle-income countries (LMCs) in publications describing oncology randomized control trials (RCTs) over a decade. Methods: We used Medline to ...

    • Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis 

      Tricarico, Rossella; Cortellino, Salvatore; Riccio, Antonio; Jagmohan-Changur, Shantie; van der Klift, Heleen; Wijnen, Juul; Turner, David; Ventura, Andrea; Rovella, Valentina; Percesepe, Antonio; Lucci-Cordisco, Emanuela; Radice, Paolo; Bertario, Lucio; Pedroni, Monica; de Leon, Maurizio Ponz; Mancuso, Pietro; Devarajan, Karthik; Cai, Kathy Q.; Klein-Szanto, Andres J.P.; Neri, Giovanni; Møller, Pål; Viel, Alessandra; Genuardi, Maurizio; Fodde, Riccardo; Bellacosa, Alfonso (Impact Journals LLC, 2015)
      The DNA glycosylase gene MBD4 safeguards genomic stability at CpG sites and is frequently mutated at coding poly-A tracks in mismatch repair (MMR)-defective colorectal tumors (CRC). Mbd4 biallelic inactivation in mice ...

    • The Involvement of Protease Nexin-1 (PN1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration 

      Wu, Xinghuo; Liu, Wei; Duan, Zhenfeng; Gao, Yong; Li, Shuai; Wang, Kun; Song, Yu; Shao, Zengwu; Yang, Shuhua; Yang, Cao (Nature Publishing Group, 2016)
      Protease nexin-1 (PN-1) is a serine protease inhibitor belonging to the serpin superfamily. This study was undertaken to investigate the regulatory role of PN-1 in the pathogenesis of intervertebral disk (IVD) degeneration. ...

    • Involvement of Skeletal Muscle Gene Regulatory Network in Susceptibility to Wound Infection Following Trauma 

      Apidianakis, Yiorgos; Mindrinos, Michael N.; Xiao, Wenzhong; Tegos, George; Papisov, Mikhail Ivanovich; Hamblin, Michael; Davis, Ronald W.; Tompkins, Ronald Gary; Rahme, Laurence G. (Public Library of Science, 2007)
      Despite recent advances in our understanding the pathophysiology of trauma, the basis of the predisposition of trauma patients to infection remains unclear. A Drosophila melanogaster/Pseudomonas aeruginosa injury and ...

    • Involvement of soluble guanylate cyclase α1 and α2, and SKCa channels in NANC relaxation of mouse distal colon 

      Dhaese, Ingeborg; Vanneste, Gwen; Sips, Patrick; Buys, Emmanuel; Brouckaert, Peter; Lefebvre, Romain A. (Elsevier BV, 2008)
      In distal colon, both nitric oxide (NO) and ATP are involved in non-adrenergic non-cholinergic (NANC) inhibitory neurotransmission. The role of the soluble guanylate cyclase (sGC) isoforms α1β1 and α2β1, and of the small ...

    • Involvement of the TCR Cβ FG Loop in Thymic Selection and T Cell Function 

      Sasada, Tetsuro; Touma, Maki; Chang, Hsiu-Ching; Clayton, Linda K.; Wang, Jia-huai; Reinherz, Ellis L. (Rockefeller University Press, 2002)
      The asymmetric disposition of T cell receptor (TCR) Cbeta and Calpha ectodomains creates a cavity with a side-wall formed by the rigid Cbeta FG loop. To investigate the significance of this conserved structure, we generated ...

    • The Involving Roles of Intrahepatic and Extrahepatic Stem/Progenitor Cells (SPCs) to Liver Regeneration 

      Liu, Wei-hui; Ren, Li-na; Wang, Tao; Navarro-Alvarez, Nalu; Tang, Li-jun (Ivyspring International Publisher, 2016)
      Liver regeneration is usually attributed to mature hepatocytes, which possess a remarkable potential to proliferate under mild to moderate injury. However, when the liver is severely damaged or hepatocyte proliferation is ...

    • In Vitro Fertilization in Women With Inflammatory Bowel Disease Is as Successful as in Women From the General Infertility Population 

      Oza, Sveta Shah; Pabby, Vikas; Moragianni, Vasiliki A.; Correia, Katharine; Ibrahim, Yetunde; Penzias, Alan S.; Burakoff, Robert; Friedman, Sonia; Cheifetz, Adam S.; Hacker, Michele; Dodge, Laura; Missmer, Stacey; Fox, Janis (Elsevier BV, 2015-09)
      BACKGROUND and AIMS: Inflammatory bowel disease (IBD) affects women of reproductive age, so there are concerns about its effects on fertility. We investigated the success of in vitro fertilization (IVF) in patients with ...

    • In Vivo Confocal Microscopic Changes of the Corneal Epithelium and Stroma in Patients With Herpes Zoster Ophthalmicus 

      Hamrah, Pedram; Sahin, Afsun; Dastjerdi, Mohammad H.; Shahatit, Bashar M.; Bayhan, Hasan A.; Dana, Reza; Pavan-Langston, Deborah (Elsevier BV, 2015)
      Purpose To analyze the density and morphology of corneal epithelial cells and keratocytes by in vivo confocal microscopy (IVCM) in patients with herpes zoster ophthalmicus (HZO) as associated with corneal innervation. ...

    • Iodinated Contrast Opacification Gradients in Normal Coronary Arteries Imaged With Prospectively ECG-Gated Single Heart Beat 320-Detector Row Computed Tomography 

      Steigner, Michael L.; Mitsouras, Dimitrios; Whitmore, A. G.; Otero, H. J.; Wang, C.; Buckley, O.; Levit, N. A.; Hussain, A. Z.; Cai, Tianxi; Mather, R. T.; Smedby, O.; DiCarli, M. F.; Rybicki, F (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background To define and evaluate coronary contrast opacification gradients using prospectively ECG-gated single heart beat 320-detector row coronary angiography (CTA). Methods and Results Thirty-six patients with ...

    • Ion channels and calcium signaling in motile cilia 

      Doerner, Julia F; Delling, Markus; Clapham, David E (eLife Sciences Publications, Ltd, 2015)
      The beating of motile cilia generates fluid flow over epithelia in brain ventricles, airways, and Fallopian tubes. Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function ...

    • Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment 

      Budczies, Jan; Pfarr, Nicole; Stenzinger, Albrecht; Treue, Denise; Endris, Volker; Ismaeel, Fakher; Bangemann, Nikola; Blohmer, Jens-Uwe; Dietel, Manfred; Loibl, Sibylle; Klauschen, Frederick; Weichert, Wilko; Denkert, Carsten (Impact Journals LLC, 2016)
      Recently, it has been demonstrated that calling of copy number alterations (CNAs) from amplicon sequencing (AS) data is feasible. Most approaches, however, require non-tumor (germline) DNA for data normalization. Here, we ...