Browsing HMS Scholarly Articles by Keyword "bioinformatics"
Now showing items 21-32 of 32
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Integrative Genomic Data Mining for Discovery of Potential Blood-Borne Biomarkers for Early Diagnosis of Cancer
(Public Library of Science, 2008)Background: With the arrival of the postgenomic era, there is increasing interest in the discovery of biomarkers for the accurate diagnosis, prognosis, and early detection of cancer. Blood-borne cancer markers are favored ... -
Meta-analysis of transcriptome data identifies a novel 5-gene pancreatic adenocarcinoma classifier
(Impact Journals LLC, 2016)Purpose Pancreatic ductal adenocarcinoma (PDAC) is largely incurable due to late diagnosis. Superior early detection biomarkers are critical to improving PDAC survival and risk stratification. Experimental Design Optimized ... -
A Network of Conserved Damage Survival Pathways Revealed by a Genomic RNAi Screen
(Public Library of Science, 2009)Damage initiates a pleiotropic cellular response aimed at cellular survival when appropriate. To identify genes required for damage survival, we used a cell-based RNAi screen against the Drosophila genome and the alkylating ... -
A novel analytical framework for dissecting the genetic architecture of behavioral symptoms in neuropsychiatric disorders
(Public Library of Science, 2010)Background: For diagnosis of neuropsychiatric disorders, a categorical classification system is often utilized as a simple way for conceptualizing an often complex clinical picture. This approach provides an unsatisfactory ... -
A Practical Platform for Blood Biomarker Study by Using Global Gene Expression Profiling of Peripheral Whole Blood
(Public Library of Science, 2009)Background: Although microarray technology has become the most common method for studying global gene expression, a plethora of technical factors across the experiment contribute to the variable of genome gene expression ... -
Sensitive Detection of Chromosomal Segments of Distinct Ancestry in Admixed Populations
(Public Library of Science, 2009)Identifying the ancestry of chromosomal segments of distinct ancestry has a wide range of applications from disease mapping to learning about history. Most methods require the use of unlinked markers; but, using all markers ... -
Statistical Resolution of Ambiguous HLA Typing Data
(Public Library of Science, 2008)High-resolution HLA typing plays a central role in many areas of immunology, such as in identifying immunogenetic risk factors for disease, in studying how the genomes of pathogens evolve in response to immune selection ... -
Systematic Evaluation of Factors Influencing ChIP-Seq Fidelity
(Nature Publishing Group, 2012)We performed a systematic evaluation of how variations in sequencing depth and other parameters influence interpretation of Chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) experiments. Using Drosophila ... -
Tissue and Process Specific microRNA–mRNA Co-Expression in Mammalian Development and Malignancy
(Public Library of Science, 2009)An association between enrichment and depletion of microRNA (miRNA) binding sites, 3′ UTR length, and mRNA expression has been demonstrated in various developing tissues and tissues from different mature organs; but ... -
A Tool to Utilize Adverse Effect Profiles to Identify Brain-Active Medications for Repurposing
(Oxford University Press, 2015)Background: To shorten the time required to bring new treatments to clinics, recent efforts have focused on repurposing existing Food and Drug Administration (FDA)-approved drugs with established safety data for new ... -
Towards a Rigorous Assessment of Systems Biology Models: The DREAM3 Challenges
(Public Library of Science, 2010)Background: Systems biology has embraced computational modeling in response to the quantitative nature and increasing scale of contemporary data sets. The onslaught of data is accelerating as molecular profiling technology ... -
Transmission of Vibrio cholerae Is Antagonized by Lytic Phage and Entry into the Aquatic Environment
(Public Library of Science, 2008)Cholera outbreaks are proposed to propagate in explosive cycles powered by hyperinfectious Vibrio cholerae and quenched by lytic vibriophage. However, studies to elucidate how these factors affect transmission are lacking ...