Browsing HMS Scholarly Articles by Title
Now showing items 3233-3252 of 17922
-
Computational Prediction of Transcription-Factor Binding Site Locations
(BioMed Central, 2003)Identifying genomic locations of transcription-factor binding sites, particularly in higher eukaryotic genomes, has been an enormous challenge. Various experimental and computational approaches have been used to detect ... -
Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer
(Public Library of Science, 2016)Molecular research in cancer is one of the largest areas of bioinformatic investigation, but it remains a challenge to understand biomolecular mechanisms in cancer-related pathways from high-throughput genomic data. This ... -
A Computational Screen for Regulators of Oxidative Phosphorylation Implicates SLIRP in Mitochondrial RNA Homeostasis
(Public Library of Science, 2009)The human oxidative phosphorylation (OxPhos) system consists of approximately 90 proteins encoded by nuclear and mitochondrial genomes and serves as the primary cellular pathway for ATP biosynthesis. While the core protein ... -
Computationally designed antibody–drug conjugates self-assembled via affinity ligands
(Springer Science and Business Media LLC, 2019-11-04)Antibody–drug conjugates (ADCs) combine the high specificity of antibodies with cytotoxic payloads. However, current strategies for the synthesis of ADCs either yield unstable or heterogeneous products or involve complex ... -
Computationally Guided High-Throughput Design of Self-Assembling Drug Nanoparticles
(Nature Publishing Group, Springer, 2021-03-25)Nanoformulations of therapeutic drugs are transforming our ability to effectively deliver and treat a myriad of conditions. Often, however, they are complex to produce and exhibit low drug loading, except for nanoparticles ... -
Computed modeling of alternating electric fields therapy for recurrent glioblastoma
(John Wiley & Sons, Ltd, 2015)Tumor treating fields (TTFields) are alternating electric fields frequency tuned to 200 kHz for the treatment of recurrent glioblastoma. We report a patient treated with TTFields and determined the distribution of TTFields ... -
Computed Tomography-Based Muscle Attenuation and Electrical Impedance Myography as Indicators of Trunk Muscle Strength Independent of Muscle Size in Older Adults
(Ovid Technologies (Wolters Kluwer Health), 2014)Objective—To examine the associations of computed tomography (CT) -based x-ray attenuation and paraspinal electrical impedance myography (EIM) measures of trunk muscles with absolute and relative (normalized by body weight) ... -
Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma
(Public Library of Science, 2016)Introduction: Confocal laser endomicroscopy (CLE) is becoming a popular method for optical biopsy of digestive mucosa for both diagnostic and therapeutic procedures. Computer aided diagnosis of CLE images, using image ... -
A computer program for the estimation of protein and nucleic acid sequence diversity in random point mutagenesis libraries
(Oxford University Press, 2005)A computer program for the generation and analysis of in silico random point mutagenesis libraries is described. The program operates by mutagenizing an input nucleic acid sequence according to mutation parameters specified ... -
Computer vision and augmented reality in gastrointestinal endoscopy
(Oxford University Press, 2015)Augmented reality (AR) is an environment-enhancing technology, widely applied in the computer sciences, which has only recently begun to permeate the medical field. Gastrointestinal endoscopy—which relies on the integration ... -
Computer-Based Drug-Utilization Review — Risk, Benefit, or Boondoggle?
(New England Journal of Medicine (NEJM/MMS), 1995)On October 28, 1990, with little debate, Congress passed the Omnibus Budget Reconciliation Act, requiring the states to provide claims-based drug-utilization review to approximately 34 million Medicaid enrollees. The ... -
Computerized Cognitive Training with Older Adults: A Systematic Review
(Public Library of Science, 2012)A systematic review to examine the efficacy of computer-based cognitive interventions for cognitively healthy older adults was conducted. Studies were included if they met the following criteria: average sample age of at ... -
Computing DNA Duplex Instability Profiles Efficiently with a Two-State Model: Trends of Promoters and Binding Sites
(BioMed Central, 2010)Background: DNA instability profiles have been used recently for predicting the transcriptional start site and the location of core promoters, and to gain insight into promoter action. It was also shown that the use of ... -
Computing Health Quality Measures Using Informatics for Integrating Biology and the Bedside
(JMIR Publications Inc., 2013)Background: The Health Quality Measures Format (HQMF) is a Health Level 7 (HL7) standard for expressing computable Clinical Quality Measures (CQMs). Creating tools to process HQMF queries in clinical databases will become ... -
COMT Genetic Variation Confers Risk for Psychotic and Affective Disorders: A Case Control Study
(BioMed Central, 2005)Background: Variation in the COMT gene has been implicated in a number of psychiatric disorders, including psychotic, affective and anxiety disorders. The majority of these studies have focused on the functional Val108/158Met ... -
COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study
(Dove Medical Press, 2014)We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene, and white matter changes ... -
Concentrated Ambient Particles Alter Myocardial Blood Flow During Acute Ischemia in Conscious Canines
(National Institute of Environmental Health Sciences, 2008)Background: Experimental and observational studies have demonstrated that short-term exposure to ambient particulate matter (PM) exacerbates myocardial ischemia. Objectives: We conducted this study to investigate the effects ... -
The Concentration-Response Relation Between PM\(_{2.5}\) and Daily Deaths.
(National Institute of Environmental Health Sciences, 2002)Particulate air pollution at commonly occurring concentrations is associated with daily deaths. Recent attention has focused on the shape of the concentration-response curve, particularly at low doses. Several recent ... -
Concentric Tube Robot Design and Optimization Based on Task and Anatomical Constraints
(Institute of Electrical and Electronics Engineers (IEEE), 2015)Concentric tube robots are catheter-sized continuum robots that are well suited for minimally invasive surgery inside confined body cavities. These robots are constructed from sets of pre-curved superelastic tubes and are ... -
Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies
(BioMed Central, 2015)Background: In addition to HLA genetic incompatibility, non-HLA difference between donor and recipients of transplantation leading to allograft rejection are now becoming evident. We aimed to create a unique genome-wide ...