Browsing HMS Scholarly Articles by Title

Now showing items 9279-9298 of 17928

    • Iodinated Contrast Opacification Gradients in Normal Coronary Arteries Imaged With Prospectively ECG-Gated Single Heart Beat 320-Detector Row Computed Tomography 

      Steigner, Michael L.; Mitsouras, Dimitrios; Whitmore, A. G.; Otero, H. J.; Wang, C.; Buckley, O.; Levit, N. A.; Hussain, A. Z.; Cai, Tianxi; Mather, R. T.; Smedby, O.; DiCarli, M. F.; Rybicki, F (Ovid Technologies (Wolters Kluwer Health), 2009)
      Background To define and evaluate coronary contrast opacification gradients using prospectively ECG-gated single heart beat 320-detector row coronary angiography (CTA). Methods and Results Thirty-six patients with ...

    • Ion channels and calcium signaling in motile cilia 

      Doerner, Julia F; Delling, Markus; Clapham, David E (eLife Sciences Publications, Ltd, 2015)
      The beating of motile cilia generates fluid flow over epithelia in brain ventricles, airways, and Fallopian tubes. Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function ...

    • Ioncopy: a novel method for calling copy number alterations in amplicon sequencing data including significance assessment 

      Budczies, Jan; Pfarr, Nicole; Stenzinger, Albrecht; Treue, Denise; Endris, Volker; Ismaeel, Fakher; Bangemann, Nikola; Blohmer, Jens-Uwe; Dietel, Manfred; Loibl, Sibylle; Klauschen, Frederick; Weichert, Wilko; Denkert, Carsten (Impact Journals LLC, 2016)
      Recently, it has been demonstrated that calling of copy number alterations (CNAs) from amplicon sequencing (AS) data is feasible. Most approaches, however, require non-tumor (germline) DNA for data normalization. Here, we ...

    • Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus 

      DeCaen, Paul G; Takahashi, Yuka; Krulwich, Terry A; Ito, Masahiro; Clapham, David E (eLife Sciences Publications, Ltd, 2014)
      Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for ...

    • Ionizing Radiation Induces Stemness in Cancer Cells 

      Ghisolfi, Laura; Keates, Andrew C.; Hu, Xingwang; Lee, Dong-ki; Li, Chiang-Jia (Public Library of Science, 2012)
      The cancer stem cell (CSC) model posits the presence of a small number of CSCs in the heterogeneous cancer cell population that are ultimately responsible for tumor initiation, as well as cancer recurrence and metastasis. ...

    • Ionizing Radiation Stimulates a Grb2-mediated Association of the Stress-activated Protein Kinase with Phosphatidylinositol 3-Kinase 

      Kharbanda, Surender; Saleem, Ahamed; Shafman, Timothy; Emoto, Yutaka; Taneja, Neelam; Rubin, Eric; Weichselbaum, Ralph; Woodgett, James; Avruch, Joseph; Kyriakis, John; Kufe, Donald (American Society for Biochemistry and Molecular Biology, 1995)

    • Ionoacoustic tomography of the proton Bragg peak in combination with ultrasound and optoacoustic imaging 

      Kellnberger, Stephan; Assmann, Walter; Lehrack, Sebastian; Reinhardt, Sabine; Thirolf, Peter; Queirós, Daniel; Sergiadis, George; Dollinger, Günther; Parodi, Katia; Ntziachristos, Vasilis (Nature Publishing Group, 2016)
      Ions provide a more advantageous dose distribution than photons for external beam radiotherapy, due to their so-called inverse depth dose deposition and, in particular a characteristic dose maximum at their end-of-range ...

    • An iOS Framework for the Indivo X Personally Controlled Health Record 

      Pfiffner, Pascal B; Mandl, Kenneth D (American Medical Informatics Association, 2013)
      The Indivo X personally controlled health record creates a channel between researchers and the patient/subject in several large scale projects. Indivo enables patients to access their health data through a web interface ...

    • The Iowa Gambling Task and the three fallacies of dopamine in gambling disorder 

      Linnet, Jakob (Frontiers Media S.A., 2013)
      Gambling disorder sufferers prefer immediately larger rewards despite long term losses on the Iowa Gambling Task (IGT), and these impairments are associated with dopamine dysfunctions. Dopamine is a neurotransmitter linked ...

    • Ipilimumab administration for advanced melanoma in patients with pre-existing Hepatitis B or C infection: a multicenter, retrospective case series 

      Ravi, Sowmya; Spencer, Kristen; Ruisi, Mary; Ibrahim, Nageatte; Luke, Jason J; Thompson, John A; Shirai, Keisuke; Lawson, David; Bartell, Heddy; Kudchadkar, Ragini; Gunter, Ngoc Thi; Mehnert, Janice M; Lipson, Evan J (BioMed Central, 2014)
      Ipilimumab is a fully human, monoclonal antibody directed against Cytotoxic T Lymphocyte Antigen-4 (CTLA-4) that has demonstrated a survival benefit and durable disease control in patients with advanced melanoma. Ipilimumab ...

    • Ipilimumab in the treatment of metastatic melanoma: management of adverse events 

      Della Vittoria Scarpati, Giuseppina; Fusciello, Celeste; Perri, Francesco; Sabbatino, Francesco; Ferrone, Soldano; Carlomagno, Chiara; Pepe, Stefano (Dove Medical Press, 2014)
      Recently, “ipilimumab,” an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. “CTLA-4” is an immune-checkpoint molecule that ...

    • Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review 

      Schoenfeld, Jonathan D.; Mahadevan, Anand; Floyd, Scott R.; Dyer, Michael A.; Catalano, Paul J.; Alexander, Brian M.; McDermott, David F.; Kaplan, Irving D. (BioMed Central, 2015)
      Background: Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor survival and are often treated with radiation. Therefore, ...

    • iProteinDB: An Integrative Database of Drosophila Post-translational Modifications 

      Hu, Yanhui; Sopko, Richelle; Chung, Verena; Foos, Marianna; Studer, Romain A.; Landry, Sean D.; Liu, Daniel; Rabinow, Leonard; Gnad, Florian; Beltrao, Pedro; Perrimon, Norbert (Genetics Society of America, 2018-11-05)
      Post-translational modification (PTM) serves as a regulatory mechanism for protein function, influencing their stability, interactions, activity and localization, and is critical in many signaling pathways. The best ...

    • IQGAP1 and IQGAP2 are Reciprocally Altered in Hepatocellular Carcinoma 

      White, Colin David; Khurana, Hema; Gnatenko, Dmitri V; Li, Zhigang; Odze, Robert D.; Sacks, David Barry; Schmidt, Valentina A (BioMed Central, 2010)
      Background: IQGAP1 and IQGAP2 are homologous members of the IQGAP family of scaffold proteins. Accumulating evidence implicates IQGAPs in tumorigenesis. We recently reported that IQGAP2 deficiency leads to the development ...

    • IQGAP1-Dependent Signaling Pathway Regulates Endothelial Cell Proliferation and Angiogenesis 

      Meyer, Rosana D.; Sacks, David Barry; Rahimi, Nader (Public Library of Science, 2008)
      Background: Vascular endothelial growth factor receptor-2 (VEGFR-2) signaling is an obligate requirement for normal development and pathological angiogenesis such as cancer and age-related macular degeneration. Although ...

    • IRE1α Activation Protects Mice Against Acetaminophen-Induced Hepatotoxicity 

      Hur, Kyu Yeon; So, Jae-Seon; Ruda, Vera; Frank-Kamenetsky, Maria; Fitzgerald, Kevin; Koteliansky, Victor; Iwawaki, Takao; Glimcher, Laurie Hollis; Lee, Ann-Hwee (The Rockefeller University Press, 2012)
      Mice lacking the transcription factor XBP1 exhibit constitutive activation of the stress sensor IRE1α and are protected from acetaminophen overdose–induced acute liver failure.

    • IRF3 and type I interferons fuel a fatal response to myocardial infarction 

      King, Kevin R; Aguirre, Aaron Dominic; Ye, Yu-Xiang; Sun, Yuan; Roh, Jason David; Ng, Richard Patrick; Kohler, Rainer H.; Arlauckas, Sean Philip; Iwamoto, Yoshiko; Savol, Andrej J; Sadreyev, Ruslan; Kelly, Mark; Fitzgibbons, Timothy P; Fitzgerald, Katherine A; Mitchison, Timothy J.; Libby, Peter; Nahrendorf, Matthias; Weissleder, Ralph (Springer Nature, 2017)
      Interferon regulatory factor 3 (IRF3) and type I interferons (IFNs) protect against infections and cancer, but excessive IRF3 activation and type I IFN production cause autoinflammatory conditions such as Aicardi–Goutières ...

    • Irisin and the therapeutic benefits of exercise 

      Spiegelman, Bruce Michael; Korsmeyer, Stanley J (BioMed Central, 2012)

    • Irisin Levels Are Lower in Young Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletes and Are Associated with Bone Density and Strength Estimates 

      Singhal, Vibha; Lawson, Elizabeth A.; Ackerman, Kathryn E.; Fazeli, Pouneh K.; Clarke, Hannah; Lee, Hang; Eddy, Kamryn; Marengi, Dean A.; Derrico, Nicholas P.; Bouxsein, Mary L.; Misra, Madhusmita (Public Library of Science, 2014)
      Irisin and FGF21 are novel hormones implicated in the “browning” of white fat, thermogenesis, and energy homeostasis. However, there are no data regarding these hormones in amenorrheic athletes (AA) (a chronic energy deficit ...

    • Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval 

      Park, Sung Kyun; Hu, Howard; Wright, Robert O.; Schwartz, Joel David; Cheng, Yawen; Sparrow, David; Vokonas, Pantel S; Weisskopf, Marc G. (National Institute of Environmental Health Sciences, 2008)
      Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance ...