Browsing HMS Scholarly Articles by Title
Now showing items 9615-9634 of 17928
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Leukotriene B4-Driven Neutrophil Recruitment to the Skin Is Essential for Allergic Skin Inflammation
(Elsevier BV, 2012)Scratching triggers skin flares in atopic dermatitis. We demonstrate that scratching of human skin and tape stripping of mouse skin cause neutrophil influx. In mice, this influx was largely dependent on the generation of ... -
Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation
(The American Association of Immunologists, 2008)Foxp3 expressing CD4+CD25+ regulatory T cells (Tregs) have been shown to prevent allograft rejection in clinical and animal models of transplantation. However, the role of Foxp3 in regulating Treg function, and the kinetics ... -
Levels of Lead in Breast Milk and Their Relation to Maternal Blood and Bone Lead Levels at One Month Postpartum.
(National Institute of Environmental Health Sciences, 2004)Despite the many well-recognized benefits of breast-feeding for both mothers and infants, detectable levels of lead in breast milk have been documented in population studies of women with no current environmental or ... -
Levels of Oxidized LDL and Advanced Glycation End Products–Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes
(American Diabetes Association, 2011)OBJECTIVE High cholesterol levels in circulating immune complexes (IC), surrogate markers of modified LDL, are associated with increased carotid intima-media thickness (IMT) and cardiovascular events in type 1 diabetes. ... -
Levels of Vascular Endothelial Growth Factor-A165b (VEGF-A165b) are Elevated in Experimental Glaucoma
(Molecular Vision, 2008)Purpose: Although ischemia has previously been suggested to contribute to the pathogenesis of glaucoma, neovascularization is not implicated in glaucoma. Because vascular endothelial growth factor-A (VEGF-A) is a key ... -
Leveraging community health worker system to map a mountainous rural district in low resource setting: a low-cost approach to expand use of geographic information systems for public health
(BioMed Central, 2014)Background: Geographic Information Systems (GIS) have become an important tool in monitoring and improving health services, particularly at local levels. However, GIS data are often unavailable in rural settings and ... -
Leveraging Genetics to Advance Type 2 Diabetes Prevention
(Public Library of Science, 2016)In this Perspective, Jose Florez discusses how information from genetics and genomics may be able to contribute to prevention of type 2 diabetes and predicting individual responses to behavioral and other interventions. -
Leveraging population admixture to explain missing heritability of complex traits
(2014)Despite recent progress on estimating the heritability explained by genotyped SNPs (hg2), a large gap between hg2 and estimates of total narrow-sense heritability (h2) remains. Explanations for this gap include rare variants, ... -
Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea
(Elsevier, 2014)Summary The prevalence of hearing loss after damage to the mammalian cochlea has been thought to be due to a lack of spontaneous regeneration of hair cells, the primary receptor cells for sound. Here, we show that supporting ... -
LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11
(Society for Neuroscience, 2017)In the developing cerebral cortex, sequential transcriptional programs take neuroepithelial cells from proliferating progenitors to differentiated neurons with unique molecular identities. The regulatory changes that occur ... -
Liberation of desmosine and isodesmosine as amino acids from insoluble elastin by elastolytic proteases
(Elsevier BV, 2011)The development of atherosclerotic lesions and abdominal aortic aneurysms involves degradation and loss of extracellular matrix components, such as collagen and elastin. Releases of the elastin cross-links desmosine (DES) ... -
Life Course Socioeconomic Position and C-Reactive Protein: Mediating Role of Health-Risk Behaviors and Metabolic Alterations. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
(Public Library of Science, 2014)Background: Chronic inflammation has been postulated to be one mediating mechanism explaining the association between low socioeconomic position (SEP) and cardiovascular disease (CVD). We sought to examine the association ... -
Life Goals Collaborative Care for Patients With Bipolar Disorder and Cardiovascular Disease Risk
(American Psychiatric Publishing, 2012)Objectives The goal of this randomized controlled pilot study was to determine whether Life Goals Collaborative Care (LGCC) compared to enhanced treatment as usual, reduced cardiometabolic factors and improved outcomes ... -
Life Sciences and the web: a new era for collaboration
(Nature Publishing Group, 2008)The World Wide Web has revolutionized how researchers from various disciplines collaborate over long distances. This is nowhere more important than in the Life Sciences, where interdisciplinary approaches are becoming ... -
Life Without Perlecan Has Its Problems
(Rockefeller University Press, 1999-11-29)Perlecan plays an important tole in basement membranes and other extracellular matrices. Mice with a knockout gene for perlecan die at or before birth with severe defects in the brain, heart, and skeleton. -
The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed
(BioMed Central, 2014)Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors regulate the ... -
Lifespan Extension Conferred by Endoplasmic Reticulum Secretory Pathway Deficiency Requires Induction of the Unfolded Protein Response
(Public Library of Science, 2014)Cells respond to accumulation of misfolded proteins in the endoplasmic reticulum (ER) by activating the unfolded protein response (UPR) signaling pathway. The UPR restores ER homeostasis by degrading misfolded proteins, ... -
The Lifespan Extension Effects of Resveratrol are Conserved in the Honey Bee and May Be Driven by a Mechanism Related to Caloric Restriction
(Impact Journals LLC, 2012)Our interest in healthy aging and in evolutionarily conserved mechanisms of lifespan extension prompted us to investigate whether features of age-related decline in the honey bee could be attenuated with resveratrol. ... -
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability
(Public Library of Science, 2007)Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development are highly conserved ... -
Lifestyle Counseling in Routine Care and Long-Term Glucose, Blood Pressure, and Cholesterol Control in Patients With Diabetes
(American Diabetes Association, 2012)OBJECTIVE In clinical trials, diet, exercise, and weight counseling led to short-term improvements in blood glucose, blood pressure, and cholesterol levels in patients with diabetes. However, little is known about the ...