Browsing HMS Scholarly Articles by Title

Now showing items 981-1000 of 17922

    • Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae 

      Hu, Yanhui; Rolfs, Andreas; Bhullar, Bhupinder; Murthy, Tellamraju S.; Zhu, Cong; Berger, Michael F.; Camargo, Anamaria A.; Kelley, Fontina; McCarron, Seamus; Jepson, Daniel; Richardson, Aaron; Raphael, Jacob; Moreira, Donna; Taycher, Elena; Zuo, Dongmei; Mohr, Stephanie; Kane, Michael F.; Williamson, Janice; Simpson, Andrew; Bulyk, Martha L.; Harlow, Edward; Marsischky, Gerald; Kolodner, Richard D.; LaBaer, Joshua (Cold Spring Harbor Laboratory Press, 2007)
      The availability of an annotated genome sequence for the yeast Saccharomyces cerevisiae has made possible the proteome-scale study of protein function and protein-protein interactions. These studies rely on availability ...

    • “Appropriate” diagnostic testing: supporting diagnostics with evidence-based medicine and shared decision making 

      Polaris, Julian JZ; Katz, Jeffrey N (BioMed Central, 2014)
      Background: Evidence-based medicine is an important approach to avoiding care that is unlikely to benefit patients in both the treatment and the diagnostic context. The medical evidence alone may not determine the most ...

    • APRIL Signaling via TACI Mediates Immunosuppression by T Regulatory Cells in Multiple Myeloma: Therapeutic Implications 

      Tai, Yu-Tzu; Lin, Liang; Xing, Lijie; Cho, Shih-Feng; Yu, Tengteng; Acharya, Chirag; Wen, Kenneth; Hsieh, Phillip A.; Dulos, John; van Elsas, Andrea; Munshi, Nikhil; Richardson, Paul; Anderson, Kenneth (Springer Science and Business Media LLC, 2019-02-01)
      We here investigate how APRIL impacts immune regulatory T cells and directly contributes to the immunosuppressive multiple myeloma (MM) bone marrow (BM) microenvironment. First, APRIL receptor TACI expression is significantly ...

    • Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities 

      Xiao, Zeyu; Farokhzad, Omid (American Chemical Society (ACS), 2012-05-10)
      With advances in aptamer selection technologies and nanomedicine, aptamer-functionalized nanoparticles are being explored as promising platforms for targeted therapeutic and diagnostic applications. In this Perspective, ...

    • AQP2 is Necessary for Vasopressin- and Forskolin-Mediated Filamentous Actin Depolymerization in Renal Epithelial Cells 

      Yui, Naofumi; Lu, Hua A Jenny; Bouley, Richard; Brown, Dennis (The Company of Biologists, 2011)
      Remodeling of the actin cytoskeleton is required for vasopressin (VP)‐induced aquaporin 2 (AQP2) trafficking. Here, we asked whether VP and forskolin (FK)‐mediated F‐actin depolymerization depends on AQP2 expression. Using ...

    • An Aquaporin 3-Notch1 Axis in Keratinocyte Differentiation and Inflammation 

      Guo, Liqiong; Chen, Hongxiang; Li, Yongsheng; Zhou, Qixing; Sui, Yang (Public Library of Science, 2013)
      Aquaporin 3 (AQP3) is an aquaglyceroporin which transports water, glycerol and small solutes across the plasma membrane. Its functions are not limited to fluid transport but also involve the regulation of cell proliferation, ...

    • Aquaporin 4 is a Ubiquitously Expressed Isoform in the Dogfish (Squalus acanthias) Shark 

      Cutler, Christopher P; MacIver, Bryce; Cramb, Gordon; Zeidel, Mark Lawrence (Frontiers Research Foundation, 2012)
      The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing. The complete coding region was then obtained using 5′ and 3′ RACE techniques. Alignment of the ...

    • Aqueous Dissolution of Alzheimer’s Disease Aβ Amyloid Deposits by Biometal Depletion 

      Cherny, Robert A.; Legg, Jacinta T.; McLean, Catriona A.; Fairlie, David P.; Huang, Xudong; Atwood, Craig S.; Beyreuther, Konrad; Tanzi, Rudolph E.; Masters, Colin L.; Bush, Ashley (American Society for Biochemistry & Molecular Biology (ASBMB), 1999-08-13)
      Zn(II) and Cu(II) precipitate Aβ in vitro into insoluble aggregates that are dissolved by metal chelators. We now report evidence that these biometals also mediate the deposition of Aβ amyloid in Alzheimer’s disease, since ...

    • AR, the Cell Cycle, and Prostate Cancer 

      Balk, Steven Paul; Knudsen, Karen E. (The Nuclear Receptor Signaling Atlas, 2008)
      The androgen receptor (AR) is a critical effector of prostate cancer development and progression. The dependence of this tumor type on AR activity is exploited in treatment of disseminated prostate cancers, wherein ablation ...

    • Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein 

      Iljina, Marija; Tosatto, Laura; Choi, Minee L.; Sang, Jason C.; Ye, Yu; Hughes, Craig D.; Bryant, Clare E.; Gandhi, Sonia; Klenerman, David (Nature Publishing Group, 2016)
      The protein alpha-synuclein (αS) self-assembles into toxic beta-sheet aggregates in Parkinson’s disease, while it is proposed that αS forms soluble alpha-helical multimers in healthy neurons. Here, we have made αS multimers ...

    • Architecture and Function of Mechanosensitive Membrane Protein Lattices 

      Kahraman, Osman; Koch, Peter D.; Klug, William S.; Haselwandter, Christoph A. (Nature Publishing Group, 2016)
      Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to modulate protein function. However, the physical ...

    • Architecture of Autoinhibited and Active BRAF–MEK1–14-3-3 Complexes 

      Rawson, Shaun; Kim, Byeong-Won; Sharif, Humayun; Jeon, Hyesung; Park, Eunyoung; Li, Kunhua; Ficarro, Scott; Gonzalez-De Pino, Gonzalo; Marto, Jarrod; Eck, Michael (Springer Science and Business Media LLC, 2019-10-03)
      RAF family kinases are RAS-activated switches that initiate signaling through the MAP kinase cascade to control cellular proliferation, differentiation and survival1-3. RAF activity is tightly regulated and inappropriate ...

    • Architecture of the Mitochondrial Calcium Uniporter 

      Oxenoid, Kirill; Dong, Ying; Cao, Chan; Cui, Tanxing; Sancak, Yasemin; Markhard, Andrew L.; Grabarek, Zenon; Kong, Liangliang; Liu, Zhijun; Ouyang, Bo; Cong, Yao; Mootha, Vamsi K.; Chou, James J. (2016)
      Mitochondria from multiple, eukaryotic clades uptake and buffer large amounts of calcium (Ca2+) via an inner membrane transporter called the uniporter. Early studies demonstrated that this transport requires a mitochondrial ...

    • Arctigenin alleviates ER stress via activating AMPK 

      Gu, Yuan; Yuan, Jun-ying; Sun, Xiao-xiao; Ye, Ji-ming; He, Li; Yan, Shou-sheng; Zhang, Hao-hao; Hu, Li-hong; Yu, Qiang (Nature Publishing Group, 2012)
      Aim: To investigate the protective effects of arctigenin (ATG), a phenylpropanoid dibenzylbutyrolactone lignan from Arctium lappa L (Compositae), against ER stress in vitro and the underlying mechanisms. Methods: A cell-based ...

    • Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales 

      Mandelblat-Cerf, Yael; Ramesh, Rohan N; Burgess, Christian R; Patella, Paola; Yang, Zongfang; Lowell, Bradford B; Andermann, Mark L (eLife Sciences Publications, Ltd, 2015)
      Agouti-related-peptide (AgRP) neurons—interoceptive neurons in the arcuate nucleus of the hypothalamus (ARC)—are both necessary and sufficient for driving feeding behavior. To better understand the functional roles of AgRP ...

    • Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association 

      Kong, Jian; Spaeth, Rosa; Cook, Amanda; Kirsch, Irving; Claggett, Brian; Vangel, Mark; Gollub, Randy L.; Smoller, Jordan W.; Kaptchuk, Ted J. (Public Library of Science, 2013)
      Placebo treatments and healing rituals have been used to treat pain throughout history. The present within-subject crossover study examines the variability in individual responses to placebo treatment with verbal suggestion ...

    • Are Chinese pediatricians missing the opportunity to help parents quit smoking? 

      Liao, Jing; Winickoff, Jonathan P.; Nong, Guangmin; Huang, Kaiyong; Yang, Li; Zhang, Zhiyong; Abdullah, Abu S. (BioMed Central, 2016)
      Background: Secondhand smoke (SHS) exposure of children due to parental tobacco use is a particularly prevalent health issue and is associated with adverse health outcomes. Following the US Clinical Practice guidelines, ...

    • Are Clinical Genomes Already Becoming Semi-Routine For Patient Care? 

      Boguski, Mark S. (BioMed Central, 2011)

    • Are Complementary Therapies and Integrative Care Cost-Effective? A Systematic Review of Economic Evaluations 

      Herman, Patricia M; Poindexter, Beth L; Witt, Claudia M; Eisenberg, David Miles (BMJ Group, 2012)
      Objective: A comprehensive systematic review of economic evaluations of complementary and integrative medicine (CIM) to establish the value of these therapies to health reform efforts. Data sources PubMed, CINAHL, AMED, ...

    • Are Dietary Bioactives Ready for Recommended Intakes?12 

      Gaine, P. Courtney; Balentine, Douglas A.; Erdman, John W.; Dwyer, Johanna T.; Ellwood, Kathleen C.; Hu, Frank B.; Russell, Robert M. (American Society for Nutrition, 2013)
      Research has shown that numerous dietary bioactive components that are not considered essential may still be beneficial to health. The dietary reference intake (DRI) process has been applied to nonessential nutrients, such ...