Browsing HMS Scholarly Articles by Keyword "Hemostasis"

Now showing items 1-3 of 3

    • Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium 

      Jain, Abhishek; van der Meer, Andries D.; Papa, Anne-Laure; Barrile, Riccardo; Lai, Angela; Schlechter, Benjamin L.; Otieno, Monicah A.; Louden, Calvert S.; Hamilton, Geraldine A.; Michelson, Alan D.; Frelinger, Andrew L.; Ingber, Donald E. (Springer US, 2016)
      The vascular endothelium and shear stress are critical determinants of physiological hemostasis and platelet function in vivo, yet current diagnostic and monitoring devices do not fully incorporate endothelial function ...

    • The efficacy of a lysine-based dendritic hydrogel does not differ from those of commercially available tissue sealants and adhesives: an ex vivo study 

      Villa-Camacho, Juan C; Ghobril, Cynthia; Anez-Bustillos, Lorenzo; Grinstaff, Mark W; Rodríguez, Edward K; Nazarian, Ara (BioMed Central, 2015)
      Background: Hemostatic agents, tissue adhesives and sealants may contribute to a reduction in hemorrhage-associated morbidity and mortality. Towards this end, we have recently developed a lysine-based dendritic hydrogel ...

    • Self-propelled particles that transport cargo through flowing blood and halt hemorrhage 

      Baylis, James R.; Yeon, Ju Hun; Thomson, Max H.; Kazerooni, Amir; Wang, Xu; St. John, Alex E.; Lim, Esther B.; Chien, Diana; Lee, Anna; Zhang, Jesse Q.; Piret, James M.; Machan, Lindsay S.; Burke, Thomas F.; White, Nathan J.; Kastrup, Christian J. (American Association for the Advancement of Science, 2015)
      Delivering therapeutics deep into damaged tissue during bleeding is challenging because of the outward flow of blood. When coagulants cannot reach and clot blood at its source, uncontrolled bleeding can occur and increase ...