Browsing HMS Scholarly Articles by Keyword "deubiquitinase"

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    • Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling 

      Jung, H; Kim, B-G; Han, W H; Lee, J H; Cho, J-Y; Park, W S; Maurice, M M; Han, J-K; Lee, M J; Finley, D; Jho, E-h (Nature Publishing Group, 2013)
      Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. Mutations ...