Browsing HMS Scholarly Articles by Keyword "differentiation"

Now showing items 1-14 of 14

    • Characterization of the Filum terminale as a neural progenitor cell niche in both rats and humans 

      Chrenek, Ryan; Magnotti, Laura M.; Herrera, Gabriella R.; Jha, Ruchira M.; Cardozo, David L. (John Wiley and Sons Inc., 2016)
      Abstract Neural stem cells (NSCs) reside in a unique microenvironment within the central nervous system (CNS) called the NSC niche. Although they are relatively rare, niches have been previously characterized in both the ...

    • CITED2 Cooperates with ISL1 and Promotes Cardiac Differentiation of Mouse Embryonic Stem Cells 

      Pacheco-Leyva, Ivette; Matias, Ana Catarina; Oliveira, Daniel V.; Santos, João M.A.; Nascimento, Rita; Guerreiro, Eduarda; Michell, Anna C.; van De Vrugt, Annebel M.; Machado-Oliveira, Gisela; Ferreira, Guilherme; Domian, Ibrahim; Bragança, José (Elsevier, 2016)
      Summary The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of CITED2 in the specification of cardiac cell fate from mouse embryonic stem cells (ESC). The overexpression ...

    • Enhancer regions show high histone H3.3 turnover that changes during differentiation 

      Deaton, Aimee M; Gómez-Rodríguez, Mariluz; Mieczkowski, Jakub; Tolstorukov, Michael Y; Kundu, Sharmistha; Sadreyev, Ruslan I; Jansen, Lars ET; Kingston, Robert E (eLife Sciences Publications, Ltd, 2016)
      The organization of DNA into chromatin is dynamic; nucleosomes are frequently displaced to facilitate the ability of regulatory proteins to access specific DNA elements. To gain insight into nucleosome dynamics, and to ...

    • Heme oxygenase-1 derived carbon monoxide permits maturation of myeloid cells 

      Wegiel, B; Hedblom, A; Li, M; Gallo, D; Csizmadia, E; Harris, C; Nemeth, Z; Zuckerbraun, B S; Soares, M; Persson, J L; Otterbein, L E (Nature Publishing Group, 2014)
      Critical functions of the immune system are maintained by the ability of myeloid progenitors to differentiate and mature into macrophages. We hypothesized that the cytoprotective gas molecule carbon monoxide (CO), generated ...

    • Hypermaintenance and hypofunction of aged spermatogonia: insight from age-related increase of Plzf expression 

      Ferder, Ianina C.; Wang, Ning (Impact Journals LLC, 2015)
      Like stem cells in other tissues, spermatogonia, including spermatogonial stem cells (SSCs) at the foundation of differentiation hierarchy, undergo age-related decline in function. The promyelocytic leukemia zinc finger ...

    • Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas 

      Shahrabi-Farahani, Shokoufeh; Wang, Lili; Zwaans, Bernadette M. M.; Santana, Jeans M.; Shimizu, Akio; Takashima, Seiji; Kreuter, Michael; Coultas, Leigh; D'Amore, Patricia A.; Arbeit, Jeffrey M.; Akslen, Lars A.; Bielenberg, Diane R. (2014)
      Neuropilins (NRP) are cell surface receptors for VEGF and SEMA3 family members. The role of NRP in neurons and endothelial cells has been investigated, but the expression and role of NRP in epithelial cells is much less ...

    • A Novel Whole-Cell Lysate Kinase Assay Identifies Substrates of the p38 MAPK in Differentiating Myoblasts 

      Knight, James DR; Tian, Ruijun; Wang, Fangjun; Beauvais, Ariane; Zou, Hanfa; Megeney, Lynn A; Gingras, Anne-Claude; Pawson, Tony; Figeys, Daniel; Kothary, Rashmi; Lee, Robin (BioMed Central, 2012)
      Background: The p38\(\alpha\) mitogen-activated protein kinase (MAPK) is a critical mediator of myoblast differentiation, and does so in part through the phosphorylation and regulation of several transcription factors and ...

    • Organized Skin Structure Is Regenerated In Vivo from Collagen-GAG Matrices Seeded with Autologous Keratinocytes 

      Compton, Carolyn C.; Butler, Charles E.; Yannas, Ioannis V.; Warland, Gretchen; Orgill, Dennis Paul (Nature Publishing Group, 1998)
      A well-characterized collagen-glycosaminoglycan matrix (CGM) that has been shown to function as a dermal analog was seeded with freshly disaggregated autologous keratinocytes and applied to full-thickness wounds in a porcine ...

    • Patents on Technologies of Human Tissue and Organ Regeneration from Pluripotent Human Embryonic Stem Cells 

      Parsons, Xuejun H; Teng, Yang D; Moore, Dennis A; Snyder, Evan Y (Bentham Science Publishers Ltd, 2011)
      Human embryonic stem cells (hESCs) are genetically stable with unlimited expansion ability and unrestricted plasticity, proffering a pluripotent reservoir for in vitro derivation of a large supply of disease-targeted human ...

    • Sox2 maintains self-renewal of tumor initiating cells in osteosarcomas 

      Basu-Roy, Upal; Seo, Eunjeong; Ramanathapuram, Lalitha; Rapp, Timothy B.; Perry, Jennifer; Orkin, Stuart Holland; Mansukhani, Alka; Basilico, Claudio (2011)
      Tumors are thought to be sustained by a reservoir of self-renewing cells, termed tumor initiating cells or cancer stem cells. Osteosarcomas are high-grade sarcomas derived from osteoblast progenitor cells and are the most ...

    • TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival 

      Walshe, T.E.; Leach, L. L.; D'Amore, Patricia Ann (Elsevier BV, 2011)
      Purpose To determine the role of TGF-β1 in the maintenance of retinal ganglion cell line (RGC-5) differentiation and integrity. Methods RGC-5 cells were differentiated in media conditioned by human non-pigmented ...

    • Transgenic Overexpression of miR-133a in Skeletal Muscle 

      Deng, Zhongliang; Chen, Jian-Fu; Wang, Da-Zhi (BioMed Central, 2011)
      Background: MicroRNAs (miRNAs) are a class of non-coding regulatory RNAs of ~22 nucleotides in length. miRNAs regulate gene expression post-transcriptionally, primarily by associating with the 3' untranslated region (UTR) ...

    • Unraveling the Transcriptional Network Controlling ES Cell Pluripotency 

      Rao, Sridhar; Orkin, Stuart Holland (BioMed Central, 2006)
      Embryonic stem cells (ES cells) are powerful tools for genetic engineering and hold significant potential for regenerative medicine. Recent work provides new insights into ES cell pluripotency and delineates separate ...

    • β-cell dedifferentiation in diabetes is important, but what is it? 

      Weir, Gordon C; Aguayo-Mazzucato, Cristina; Bonner-Weir, Susan (Landes Bioscience, 2013)
      This commentary discusses the concept of β-cell dedifferentiation in diabetes, which is important but not well defined. A broad interpretation is that a state of differentiation has been lost, which means changes in gene ...