Browsing SPH Scholarly Articles by Keyword "cellular microbiology and pathogenesis"

Now showing items 1-6 of 6

    • Comparative Proteomic Analysis of the PhoP Regulon in Salmonella enterica Serovar Typhi Versus Typhimurium 

      Lebrun, Lauren M.; Sheikh, Alaullah; Logvinenko, Tanya; Tarique, Abdullah; Krastins, Bryan; Qadri, Firdausi; Charles, Richelle Candice; Harris, Jason B.; Chase, Michael Richard; Larocque, Regina Celes; Rollins, Sean McKenzie; Hohmann, Elizabeth Louise; Rosenberg, Ian Morley; Sarracino, David A.; Calderwood, Stephen Beaven; Ryan, Edward Thomas (Public Library of Science, 2009)
      Background: S. Typhi, a human-restricted Salmonella enterica serovar, causes a systemic intracellular infection in humans (typhoid fever). In comparison, S. Typhimurium causes gastroenteritis in humans, but causes a systemic ...

    • In Vitro Priming Recapitulates In Vivo HIV-1 Specific T Cell Responses, Revealing Rapid Loss of Virus Reactive CD4+ T Cells in Acute HIV-1 Infection 

      Lubong Sabado, Rachel; Kavanagh, Daniel Garrett; Kaufmann, Daniel; Fru, Karlhans; Babcock, Ethan; Rosenberg, Eric Scott; Walker, Bruce David; Lifson, Jeffrey; Bhardwaj, Nina; Larsson, Marie (Public Library of Science, 2009)
      Background: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells ...

    • A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor 

      Hett, Erik Christian; Chao, Michael; Deng, Lynn L.; Rubin, Eric Joseph (Public Library of Science, 2008)
      The final stage of bacterial cell division requires the activity of one or more enzymes capable of degrading the layers of peptidoglycan connecting two recently developed daughter cells. Although this is a key step in cell ...

    • NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis 

      Pandey, Amit K.; Yang, Yibin; Jiang, Zhaozhao; Fortune, Sarah Merritt; Coulombe, Francois; Behr, Marcel A.; Fitzgerald, Katherine A.; Sassetti, Christopher M.; Kelliher, Michelle A. (Public Library of Science, 2009)
      While the recognition of microbial infection often occurs at the cell surface via Toll-like receptors, the cytosol of the cell is also under surveillance for microbial products that breach the cell membrane. An important ...

    • Plasma Gelsolin Depletion and Circulating Actin in Sepsis—A Pilot Study 

      Lee, Po-Shun; Patel, Sanjay R; Christiani, David C.; Bajwa, Ednan Khalid; Stossel, Thomas Peter; Waxman, Aaron Bradley (Public Library of Science, 2008)
      Background: Depletion of the circulating actin-binding protein, plasma gelsolin (pGSN) has been described in septic patients and animals. We hypothesized that the extent of pGSN reduction correlates with outcomes of septic ...

    • Systematic genetic nomenclature for type VII secretion systems 

      Bitter, Wilbert; Houben, Edith N. G.; Bottai, Daria; Brodin, Priscille; Cox, Jeffery S.; Derbyshire, Keith; Gao, Lian-Yong; Gey van Pittius, Nicolaas C.; Pym, Alexander S.; Cole, Stewart T.; Brosch, Roland; Rall, Glenn F.; Brown, Eric J.; Fortune, Sarah Merritt; Liu, Jun; Rubin, Eric Joseph; Sherman, David R. (Public Library of Science, 2009)