Browsing SPH Scholarly Articles by Keyword "epigenetics"

Now showing items 1-20 of 21

    • Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context 

      Christensen, Brock C.; Marsit, Carmen J.; Zheng, Shichun; Wrensch, Margaret R.; Wiemels, Joseph L.; Nelson, Heather H.; Karagas, Margaret R.; Padbury, James F.; Yeh, Ru-Fang; Wiencke, John K.; Kelsey, Karl T.; Houseman, Eugene Andres; Bueno, Raphael; Sugarbaker, David John (Public Library of Science, 2009)
      Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human ...

    • Biomarkers of Lead Exposure and DNA Methylation within Retrotransposons 

      Bollati, Valentina; Tarantini, Letizia; Hu, Howard; Schwartz, Joel David; Wright, Rosalind Jo; Park, Sung Kyun; Sparrow, David; Vokonas, Pantel S; Baccarelli, Andrea; Wright, Robert O. (National Institute of Environmental Health Sciences, 2010)
      Background: DNA methylation is an epigenetic mark that regulates gene expression. Changes in DNA methylation within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a ...

    • Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake 

      Christensen, Brock C.; Kelsey, Karl T.; Zheng, Shichun; Marsit, Carmen J.; Wrensch, Margaret R.; Wiemels, Joseph L.; Nelson, Heather H.; Karagas, Margaret R.; Kushi, Lawrence H.; Kwan, Marilyn L.; Wiencke, John K.; Horwitz, Marshall S.; Houseman, Eugene Andres (Public Library of Science, 2010)
      Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor ...

    • Cardiac Autonomic Dysfunction: Particulate Air Pollution Effects Are Modulated by Epigenetic Immunoregulation of Toll‐like Receptor 2 and Dietary Flavonoid Intake 

      Zhong, Jia; Colicino, Elena; Lin, Xinyi; Mehta, Amar; Kloog, Itai; Zanobetti, Antonella; Byun, Hyang‐Min; Bind, Marie‐Abèle; Cantone, Laura; Prada, Diddier; Tarantini, Letizia; Trevisi, Letizia; Sparrow, David; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A. (Blackwell Publishing Ltd, 2015)
      Background: Short‐term fine particles (PM2.5) exposure is associated with reduced heart rate variability, a strong predictor of cardiac mortality among older people. Identifying modifiable factors that confer susceptibility ...

    • A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression 

      Guintivano, Jerry; Aryee, Martin J.; Kaminsky, Zachary A. (Landes Bioscience, 2013)
      Brain cellular heterogeneity may bias cell type specific DNA methylation patterns, influencing findings in psychiatric epigenetic studies. We performed fluorescence activated cell sorting (FACS) of neuronal nuclei and ...

    • Chromatin States Accurately Classify Cell Differentiation Stages 

      Larson, Jessica Lynn; Yuan, Guocheng (Public Library of Science, 2012)
      Gene expression is controlled by the concerted interactions between transcription factors and chromatin regulators. While recent studies have identified global chromatin state changes across cell-types, it remains unclear ...

    • A Comprehensive Map of Insulator Elements for the Drosophila Genome 

      Nègre, Nicolas; Kheradpour, Pouya; Morrison, Carolyn A.; Henikoff, Jorja G.; Feng, Xin; Ahmad, Kami; Stein, Lincoln; Henikoff, Steven; White, Kevin P.; Brown, Christopher D.; Shah, Parantu; Russell, Steven; White, Robert A. H.; Kellis, Manolis (Public Library of Science, 2010)
      Insulators are DNA sequences that control the interactions among genomic regulatory elements and act as chromatin boundaries. A thorough understanding of their location and function is necessary to address the complexities ...

    • DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments 

      Bellavia, Andrea; Urch, Bruce; Speck, Mary; Brook, Robert D.; Scott, Jeremy A.; Albetti, Benedetta; Behbod, Behrooz; North, Michelle; Valeri, Linda; Bertazzi, Pier Alberto; Silverman, Frances; Gold, Diane; A. Baccarelli, Andrea (Blackwell Publishing Ltd, 2013)
      Background: Short‐term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate‐matter (PM) have been related with increased blood pressure (BP) in controlled‐human exposure and community‐based studies. However, ...

    • DNA methylation-based measures of biological age: meta-analysis predicting time to death 

      Chen, Brian H.; Marioni, Riccardo E.; Colicino, Elena; Peters, Marjolein J.; Ward-Caviness, Cavin K.; Tsai, Pei-Chien; Roetker, Nicholas S.; Just, Allan C.; Demerath, Ellen W.; Guan, Weihua; Bressler, Jan; Fornage, Myriam; Studenski, Stephanie; Vandiver, Amy R.; Moore, Ann Zenobia; Tanaka, Toshiko; Kiel, Douglas P.; Liang, Liming; Vokonas, Pantel; Schwartz, Joel; Lunetta, Kathryn L.; Murabito, Joanne M.; Bandinelli, Stefania; Hernandez, Dena G.; Melzer, David; Nalls, Michael; Pilling, Luke C.; Price, Timothy R.; Singleton, Andrew B.; Gieger, Christian; Holle, Rolf; Kretschmer, Anja; Kronenberg, Florian; Kunze, Sonja; Linseisen, Jakob; Meisinger, Christine; Rathmann, Wolfgang; Waldenberger, Melanie; Visscher, Peter M.; Shah, Sonia; Wray, Naomi R.; McRae, Allan F.; Franco, Oscar H.; Hofman, Albert; Uitterlinden, André G.; Absher, Devin; Assimes, Themistocles; Levine, Morgan E.; Lu, Ake T.; Tsao, Philip S.; Hou, Lifang; Manson, JoAnn E.; Carty, Cara L.; LaCroix, Andrea Z.; Reiner, Alexander P.; Spector, Tim D.; Feinberg, Andrew P.; Levy, Daniel; Baccarelli, Andrea; van Meurs, Joyce; Bell, Jordana T.; Peters, Annette; Deary, Ian J.; Pankow, James S.; Ferrucci, Luigi; Horvath, Steve (Impact Journals LLC, 2016)
      Estimates of biological age based on DNA methylation patterns, often referred to as “epigenetic age”, “DNAm age”, have been shown to be robust biomarkers of age in humans. We previously demonstrated that independent of ...

    • Effects of Air Pollution and Blood Mitochondrial DNA Methylation on Markers of Heart Rate Variability 

      Byun, Hyang‐Min; Colicino, Elena; Trevisi, Letizia; Fan, Tianteng; Christiani, David C.; Baccarelli, Andrea A. (Wiley-Blackwell, 2016)
      Background: The mitochondrion is the primary target of oxidative stress in response to exogenous environments. Mitochondrial DNA (mtDNA) is independent from nuclear DNA and uses separate epigenetic machinery to regulate ...

    • Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation 

      Tarantini, Letizia; Bonzini, Matteo; Apostoli, Pietro; Pegoraro, Valeria; Bollati, Valentina; Marinelli, Barbara; Cantone, Laura; Rizzo, Giovanna; Hou, Lifang; Bertazzi, Pier Alberto; Schwartz, Joel David; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2008)
      Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined.Objectives We aimed at ...

    • Epigenetics—a potential mediator between air pollution and preterm birth 

      Lin, Vania W.; Baccarelli, Andrea A.; Burris, Heather H. (2016)
      Preterm birth is a major cause of infant morbidity and mortality and a potential risk factor for adult chronic disease. With over 15 million infants born preterm worldwide each year, preterm birth poses a global health ...

    • Exposure to Metal-rich Particulate Matter Modifies the Expression of Candidate Micrornas in Peripheral Blood Leukocytes 

      Bollati, Valentina; Marinelli, Barbara; Apostoli, Pietro; Bonzini, Matteo; Nordio, Francesco; Hoxha, Mirjam; Pegoraro, Valeria; Tarantini, Letizia; Cantone, Laura; Bertazzi, Pier Alberto; Motta, Valeria; Schwartz, Joel David; Baccarelli, Andrea (National Institute of Environmental Health Sciences, 2010)
      Background: Altered patterns of gene expression mediate the effects of particulate matter (PM) on human health, but mechanisms through which PM modifies gene expression are largely undetermined. MicroRNAs (miRNAs) are ...

    • Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted 

      Poage, Graham M.; Christensen, Brock C.; McClean, Michael D.; Wiencke, John K.; Posner, Marshall R.; Nelson, Heather H.; Marsit, Carmen J.; Kelsey, Karl T.; Hoheisel, Jörg; Houseman, Eugene Andres; Clark, John Ross (Public Library of Science, 2010)
      Background: Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously ...

    • Influence of Prenatal Lead Exposure on Genomic Methylation of Cord Blood DNA 

      Pilsner, J. Richard; Hu, Howard; Sánchez, Brisa N.; Cantonwine, David; Lazarus, Alicia; Lamadrid-Figueroa, Héctor; Mercado-García, Adriana; Téllez-Rojo, Martha Maria; Hernández-Avila, Mauricio; Ettinger, Adrienne S; Wright, Robert O. (National Institute of Environmental Health Sciences, 2009)
      Background: Fetal lead exposure is associated with adverse pregnancy outcomes and developmental and cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown. Epigenetic fetal ...

    • The metabolomics of asthma control: a promising link between genetics and disease 

      McGeachie, Michael J; Dahlin, Amber; Qiu, Weiliang; Croteau-Chonka, Damien C; Savage, Jessica; Wu, Ann Chen; Wan, Emily S; Sordillo, Joanne E; Al-Garawi, Amal; Martinez, Fernando D; Strunk, Robert C; Lemanske, Robert F; Liu, Andrew H; Raby, Benjamin A; Weiss, Scott; Clish, Clary B; Lasky-Su, Jessica A (John Wiley & Sons, Ltd, 2015)
      Short-acting β agonists (e.g., albuterol) are the most commonly used medications for asthma, a disease that affects over 300 million people in the world. Metabolomic profiling of asthmatics taking β agonists presents a new ...

    • Particulate Matter, DNA Methylation in Nitric Oxide Synthase, and Childhood Respiratory Disease 

      Breton, Carrie V.; Salam, Muhammad T.; Wang, Xinhui; Byun, Hyang-Min; Siegmund, Kimberly D.; Gilliland, Frank D. (National Institute of Environmental Health Sciences, 2012)
      Background: Air pollutants have been associated with childhood asthma and wheeze. Epigenetic regulation of nitric oxide synthase—the gene responsible for nitric oxide production—may be affected by air pollutants and ...

    • Placental mitochondrial methylation and exposure to airborne particulate matter in the early life environment: An ENVIRONAGE birth cohort study 

      Janssen, Bram G; Byun, Hyang-Min; Gyselaers, Wilfried; Lefebvre, Wouter; Baccarelli, Andrea A; Nawrot, Tim S (Taylor & Francis, 2015)
      Most research to date has focused on epigenetic modifications in the nuclear genome, with little attention devoted to mitochondrial DNA (mtDNA). Placental mtDNA content has been shown to respond to environmental exposures ...

    • PTSD and DNA Methylation in Select Immune Function Gene Promoter Regions: A Repeated Measures Case-Control Study of U.S. Military Service Members 

      Rusiecki, Jennifer A.; Byrne, Celia; Galdzicki, Zygmunt; Srikantan, Vasantha; Chen, Ligong; Poulin, Matthew; Yan, Liying; Baccarelli, Andrea (Frontiers Media S.A., 2013)
      Background: The underlying molecular mechanisms of PTSD are largely unknown. Distinct expression signatures for PTSD have been found, in particular for immune activation transcripts. DNA methylation may be significant in ...

    • Systematic Evaluation of Factors Influencing ChIP-Seq Fidelity 

      Negre, Nicolas; Li, Qunhua; Mieczkowska, Joanna O.; Slattery, Matthew; Kim, Tae-Kyung; Zieba, Jennifer; Ruan, Yijun; Bickel, Peter J.; Wold, Barbara J.; Lieb, Jason D.; Chen, Yiwen; Liu, Tao; Zhang, Yong; He, Housheng H; Myers, Richard M.; White, Kevin P.; Liu, Xiaole Shirley (Nature Publishing Group, 2012)
      We performed a systematic evaluation of how variations in sequencing depth and other parameters influence interpretation of Chromatin immunoprecipitation (ChIP) followed by sequencing (ChIP-seq) experiments. Using Drosophila ...