A Method for High-Throughput Gene Expression Signature Analysis
| Title: | A Method for High-Throughput Gene Expression Signature Analysis |
| Author: |
Peck, David; Crawford, Emily D; Ross, Kenneth N; Stegmaier, Kimberly; Golub, Todd R.; Lamb, Justin
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Peck, David, Emily D. Crawford, Kenneth N. Ross, Kimberly Stegmaier, Todd R. Golub, and Justin Lamb. 2006. A method for high-throughput gene expression signature analysis. Genome Biology 7(7): R61. |
| Full Text & Related Files: |
1779561.pdf (254.4Kb; PDF) 
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| Abstract: | Genome-wide transcriptional profiling has shown that different biologic states (for instance, disease and response to pharmacologic manipulation) can be recognized by the expression pattern of relatively small numbers of genes. However, the lack of a practical and cost-effective technology for detection of these gene expression 'signatures' in large numbers of samples has severely limited their exploitation in important medical and pharmaceutical discovery applications. Here, we describe a solution based on the combination of ligation-mediated amplification with an optically addressed microsphere and flow cytometric detection system. |
| Published Version: | doi: 10.1186/gb-2006-7-7-r61 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779561/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4621133 |
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