The Bile Acid Synthesis Pathway Is Present and Functional in the Human Ovary

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The Bile Acid Synthesis Pathway Is Present and Functional in the Human Ovary

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dc.contributor.author Nierstenhoefer, Maik
dc.contributor.author Tobiasch, Edda
dc.contributor.author Usheva, Anny
dc.contributor.author Smith, Laura
dc.contributor.author Yoo, Sang Wook
dc.contributor.author Penzias, Alan Stewart
dc.date.accessioned 2011-03-16T02:35:48Z
dc.date.issued 2009
dc.identifier.citation Smith, Laura P., Maik Nierstenhoefer, Sang Wook Yoo, Alan S. Penzias, Edda Tobiasch, and Anny Usheva. 2009. The Bile Acid Synthesis Pathway Is Present and Functional in the Human Ovary. PLoS ONE 4(10): e7333. en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4742698
dc.description.abstract Background: Bile acids, end products of the pathway for cholesterol elimination, are required for dietary lipid and fat-soluble vitamin absorption and maintain the balance between cholesterol synthesis in the liver and cholesterol excretion. They are composed of a steroid structure and are primarily made in the liver by the oxidation of cholesterol. Cholesterol is also highly abundant in the human ovarian follicle, where it is used in the formation of the sex steroids. Methodology/Principal Findings: Here we describe for the first time evidence that all aspects of the bile acid synthesis pathway are present in the human ovarian follicle, including the enzymes in both the classical and alternative pathways, the nuclear receptors known to regulate the pathway, and the end product bile acids. Furthermore, we provide functional evidence that bile acids are produced by the human follicular granulosa cells in response to cholesterol presence in the culture media. Conclusions/Significance: These findings establish a novel pathway present in the human ovarian follicle that has the capacity to compete directly with sex steroid synthesis. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0007333 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752198/pdf/ en_US
dash.license LAA
dc.subject cell biology en_US
dc.subject physiology en_US
dc.subject reproductive physiology en_US
dc.subject women's health en_US
dc.subject female subfertility and gynecological endocrinology en_US
dc.title The Bile Acid Synthesis Pathway Is Present and Functional in the Human Ovary en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US
dash.depositing.author Penzias, Alan Stewart
dc.date.available 2011-03-16T02:35:48Z
dash.affiliation.other HMS^Stipendees - Div of Medical Sciences en_US
dash.affiliation.other HMS^Obstetrics Gynecology and Repro. Bio. - BIDMC en_US

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