dc.contributor.author | Cariappa, Annaiah | |
dc.contributor.author | Takematsu, Hiromu | |
dc.contributor.author | Liu, Haoyuan | |
dc.contributor.author | Diaz, Sandra | |
dc.contributor.author | Haider, Khaleda | |
dc.contributor.author | Kalloo, Geetika | |
dc.contributor.author | Varki, Nissi | |
dc.contributor.author | Varki, Ajit | |
dc.contributor.author | Boboila, Cristian | |
dc.contributor.author | Connole, Michelle Ann | |
dc.contributor.author | Shi, Hai Ning | |
dc.contributor.author | Pillai, Shiv Subramaniam | |
dc.date.accessioned | 2011-04-18T02:09:40Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Cariappa, Annaiah, Hiromu Takematsu, Haoyuan Liu, Sandra Diaz, Khaleda Haider, Cristian Boboila, Geetika Kalloo, et al. 2009. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. Journal of Experimental Medicine 206(1): 125-138. | en_US |
dc.identifier.issn | 0022-1007 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:4853404 | |
dc.description.abstract | We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of α2–6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposits. The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling. These results describe a novel catalytic regulator of B cell signaling and underscore the crucial role of inhibitory signaling in the maintenance of immunological tolerance in the B lineage. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Rockefeller University Press | en_US |
dc.relation.isversionof | doi:10.1084/jem.20081399 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626685/pdf/ | en_US |
dash.license | LAA | |
dc.title | B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Journal of Experimental Medicine | en_US |
dash.depositing.author | Connole, Michelle Ann | |
dc.date.available | 2011-04-18T02:09:40Z | |
dash.affiliation.other | HMS^New England Primate Research Center | en_US |
dash.affiliation.other | HMS^Medicine-Massachusetts General Hospital | en_US |
dash.affiliation.other | HMS^Health Sciences and Technology | en_US |
dc.identifier.doi | 10.1084/jem.20081399 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Shi, Hai | |
dash.contributor.affiliated | Connole, Michelle | |
dash.contributor.affiliated | Pillai, Shiv | |