B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase

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B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase

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dc.contributor.author Cariappa, Annaiah
dc.contributor.author Takematsu, Hiromu
dc.contributor.author Liu, Haoyuan
dc.contributor.author Diaz, Sandra
dc.contributor.author Haider, Khaleda
dc.contributor.author Kalloo, Geetika
dc.contributor.author Varki, Nissi
dc.contributor.author Varki, Ajit
dc.contributor.author Boboila, Cristian
dc.contributor.author Connole, Michelle Ann
dc.contributor.author Shi, Hai Ning
dc.contributor.author Pillai, Shiv Subramaniam
dc.date.accessioned 2011-04-18T02:09:40Z
dc.date.issued 2009
dc.identifier.citation Cariappa, Annaiah, Hiromu Takematsu, Haoyuan Liu, Sandra Diaz, Khaleda Haider, Cristian Boboila, Geetika Kalloo, et al. 2009. B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase. Journal of Experimental Medicine 206(1): 125-138. en_US
dc.identifier.issn 0022-1007 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:4853404
dc.description.abstract We show that the enzymatic acetylation and deacetylation of a cell surface carbohydrate controls B cell development, signaling, and immunological tolerance. Mice with a mutation in sialate:O-acetyl esterase, an enzyme that specifically removes acetyl moieties from the 9-OH position of α2–6-linked sialic acid, exhibit enhanced B cell receptor (BCR) activation, defects in peripheral B cell development, and spontaneously develop antichromatin autoantibodies and glomerular immune complex deposits. The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling. These results describe a novel catalytic regulator of B cell signaling and underscore the crucial role of inhibitory signaling in the maintenance of immunological tolerance in the B lineage. en_US
dc.language.iso en_US en_US
dc.publisher Rockefeller University Press en_US
dc.relation.isversionof doi:10.1084/jem.20081399 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626685/pdf/ en_US
dash.license LAA
dc.title B Cell Antigen Receptor Signal Strength and Peripheral B Cell Development are Regulated by a 9-O-Acetyl Sialic Acid Esterase en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Journal of Experimental Medicine en_US
dash.depositing.author Connole, Michelle Ann
dc.date.available 2011-04-18T02:09:40Z
dash.affiliation.other HMS^New England Primate Research Center en_US
dash.affiliation.other HMS^Medicine-Massachusetts General Hospital en_US
dash.affiliation.other HMS^Health Sciences and Technology en_US

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