Lead Exposure and Behavior Among Young Children in Chennai, India

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Lead Exposure and Behavior Among Young Children in Chennai, India

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dc.contributor.author Roy, Ananya
dc.contributor.author Hu, Howard
dc.contributor.author Bouchard, Maryse
dc.contributor.author Palaniappan, Kavitha
dc.contributor.author Balakrishnan, Kalpana
dc.contributor.author Bellinger, David C.
dc.contributor.author Schwartz, Joel David
dc.contributor.author Ettinger, Adrienne S
dc.contributor.author Wright, Robert O.
dc.date.accessioned 2012-01-21T02:02:14Z
dc.date.issued 2009
dc.identifier.citation Roy, Ananya, David Bellinger, Howard Hu, Joel Schwartz, Adrienne S. Ettinger, Robert O. Wright, Maryse Bouchard, Kavitha Palaniappan, and Kalpana Balakrishnan. 2009. Lead exposure and behavior among young children in Chennai, India. Environmental Health Perspectives 117(10): 1607-1611. en_US
dc.identifier.issn 0091-6765 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8000910
dc.description.abstract Background: Lead exposure has long been associated with deficits in IQ among children. However, few studies have assessed the impact of lead on specific domains of behavior and cognition. Objective: We evaluated the associations between lead and different domains of neurobehavior and their relative sensitivity to lead. Methods: We determined blood lead levels using a LeadCare instrument in 756 children 3–7 years of age attending pre- and elementary schools in Chennai, India. Anxiety, social problems, inattention, hyperactivity, and attention deficit hyperactivity disorder (ADHD), as well as executive function were assessed in children by their schoolteachers using Conners’ Teacher Rating Scales-39, Conners’ ADHD/Diagnostic and Statistical Manual for Mental Disorders, 4th Edition Scales (CADS), and the Behavior Rating Inventory of Executive Function questionnaires, with higher scores denoting worse behavior. Analyses were carried out using multivariate generalized estimating equations with comparisons of outcome Z-scores to assess the relative strengths of the associations between log-blood lead and the different domains of behavior. Results: Mean blood lead level was 11.4 ± 5.3 μg/dL. Blood lead was associated with higher anxiety (β = 0.27, p = 0.01), social problems (β = 0.20, p = 0.02), and higher scores in the ADHD index (β = 0.17; p = 0.05). The effect estimate was highest for global executive function (β = 0.42; p < 0.001). Conclusions: Higher blood lead levels in this population of young children is associated with increased risk of neurobehavioral deficits and ADHD, with executive function and attention being particularly vulnerable domains to the effects of lead. en_US
dc.language.iso en_US en_US
dc.publisher National Institute of Environmental Health Sciences en_US
dc.relation.isversionof doi://10.1289/ehp.0900625 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790517/pdf/ en_US
dash.license LAA
dc.subject ADHD en_US
dc.subject anxiety en_US
dc.subject blood lead en_US
dc.subject children en_US
dc.subject executive function en_US
dc.subject India en_US
dc.subject sociability en_US
dc.title Lead Exposure and Behavior Among Young Children in Chennai, India en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Environmental Health Perspectives en_US
dash.depositing.author Bellinger, David C.
dc.date.available 2012-01-21T02:02:14Z
dash.affiliation.other HMS^Neurology-Children's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Exposure Epidemiology and Risk Program en_US
dash.affiliation.other HMS^Medicine-Brigham and Women's Hospital en_US
dash.affiliation.other SPH^Environmental+Occupational Medicine+Epi en_US
dash.affiliation.other HMS^Pediatrics-Children's Hospital en_US

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