dc.contributor.author | Carrasco, Daniel R. | |
dc.contributor.author | Sukhdeo, Kumar | |
dc.contributor.author | Protopopova, Marina | |
dc.contributor.author | Enos, Miriam | |
dc.contributor.author | Zheng, Mei | |
dc.contributor.author | Mani, Mala | |
dc.contributor.author | Ivanova, Elena V. | |
dc.contributor.author | Tonon, Giovanni | |
dc.contributor.author | Sinha, Raktim | |
dc.contributor.author | Carrasco, Daniel E. | |
dc.contributor.author | Henderson, Joel Michael | |
dc.contributor.author | Pinkus, Geraldine Sowinski | |
dc.contributor.author | Munshi, Nikhil C | |
dc.contributor.author | Horner, James W. | |
dc.contributor.author | Protopopov, Alexei | |
dc.contributor.author | Anderson, Kenneth Carl | |
dc.contributor.author | DePinho, Ronald A. | |
dc.date.accessioned | 2012-02-14T00:30:54Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Carrasco, Daniel R., Kumar Sukhdeo, Marina Protopopova, Raktim Sinha, Miriam Enos, Daniel E. Carrasco, Mei Zheng, et al. 2007. The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis. Cancer Cell 11(4): 349-360. | en_US |
dc.identifier.issn | 1535-6108 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:8160855 | |
dc.description.abstract | Multiple myeloma (MM) evolves from a highly prevalent premalignant condition termed MGUS. The factors underlying the malignant transformation of MGUS are unknown. We report a MGUS/MM phenotype in transgenic mice with Eμ-directed expression of the XBP-1 spliced isoform (XBP-1s), a factor governing unfolded protein/ER stress response and plasma-cell development. Eμ-XBP-1s elicited elevated serum Ig and skin alterations. With age, Eμ-xbp-1s transgenics develop features diagnostic of human MM, including bone lytic lesions and subendothelial Ig deposition. Furthermore, transcriptional profiles of Eμ-xbp-1s lymphoid and MM cells show aberrant expression of known human MM dysregulated genes. The similarities of this model with the human disease, coupled with documented frequent XBP-1s overexpression in human MM, serve to implicate XBP-1s dysregulation in MM pathogenesis. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Cell Press | en_US |
dc.relation.isversionof | doi:10.1016/j.ccr.2007.02.015 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1885943/pdf/ | en_US |
dash.license | LAA | |
dc.subject | cell cycle | en_US |
dc.title | The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Cancer Cell | en_US |
dash.depositing.author | Pinkus, Geraldine Sowinski | |
dc.date.available | 2012-02-14T00:30:54Z | |
dash.affiliation.other | HMS^Pathology | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dash.affiliation.other | HMS^Medicine-Brigham and Women's Hospital | en_US |
dc.identifier.doi | 10.1016/j.ccr.2007.02.015 | * |
dash.authorsordered | false | |
dash.contributor.affiliated | Sinha, Raktim | |
dash.contributor.affiliated | Horner, James W. | |
dash.contributor.affiliated | Henderson, Joel | |
dash.contributor.affiliated | Protopopov, Alexei | |
dash.contributor.affiliated | DePinho, Ronald A. | |
dash.contributor.affiliated | Pinkus, Geraldine | |
dash.contributor.affiliated | Munshi, Nikhil | |
dash.contributor.affiliated | Anderson, Kenneth | |