Patient-Tailored Connectomics Visualization for the Assessment of White Matter Atrophy in Traumatic Brain Injury

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Patient-Tailored Connectomics Visualization for the Assessment of White Matter Atrophy in Traumatic Brain Injury

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dc.contributor.author Irimia, Andrei
dc.contributor.author Chambers, Micah C.
dc.contributor.author Torgerson, Carinna M.
dc.contributor.author Filippou, Maria
dc.contributor.author Hovda, David A.
dc.contributor.author Alger, Jeffry R.
dc.contributor.author Gerig, Guido
dc.contributor.author Toga, Arthur W.
dc.contributor.author Vespa, Paul M.
dc.contributor.author Van Horn, John D.
dc.contributor.author Kikinis, Ron
dc.date.accessioned 2012-03-29T17:56:02Z
dc.date.issued 2012
dc.identifier.citation Irimia, Andrei, Micah C. Chambers, Carinna M. Torgerson, Maria Filippou, David A. Hovda, Jeffry R. Alger, Guido Gerig, et al. 2012. Patient-tailored connectomics visualization for the assessment of white matter atrophy in traumatic brain injury. Frontiers in Neurology 3:10. en_US
dc.identifier.issn 1664-2295 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:8462352
dc.description.abstract Available approaches to the investigation of traumatic brain injury (TBI) are frequently hampered, to some extent, by the unsatisfactory abilities of existing methodologies to efficiently define and represent affected structural connectivity and functional mechanisms underlying TBI-related pathology. In this paper, we describe a patient-tailored framework which allows mapping and characterization of TBI-related structural damage to the brain via multimodal neuroimaging and personalized connectomics. Specifically, we introduce a graphically driven approach for the assessment of trauma-related atrophy of white matter connections between cortical structures, with relevance to the quantification of TBI chronic case evolution. This approach allows one to inform the formulation of graphical neurophysiological and neuropsychological TBI profiles based on the particular structural deficits of the affected patient. In addition, it allows one to relate the findings supplied by our workflow to the existing body of research that focuses on the functional roles of the cortical structures being targeted. A graphical means for representing patient TBI status is relevant to the emerging field of personalized medicine and to the investigation of neural atrophy. en_US
dc.language.iso en_US en_US
dc.publisher Frontiers Research Foundation en_US
dc.relation.isversionof doi://10.3389/fneur.2012.00010 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275792/pdf/ en_US
dash.license LAA
dc.subject connectonomics en_US
dc.subject traumatic brain injury en_US
dc.subject atrophy en_US
dc.subject rehabilitation en_US
dc.subject DTI en_US
dc.title Patient-Tailored Connectomics Visualization for the Assessment of White Matter Atrophy in Traumatic Brain Injury en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Frontiers in Neurology en_US
dash.depositing.author Kikinis, Ron
dc.date.available 2012-03-29T17:56:02Z

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