Browsing by Author "Mitnick, Carole"

Now showing items 1-16 of 16

    • 5-SPICE: the application of an original framework for community health worker program design, quality improvement and research agenda setting 

      Palazuelos, Daniel; Ellis, Kyla; DaEun Im, Dana; Peckarsky, Matthew; Schwarz, Dan; Farmer, Didi Bertrand; Dhillon, Ranu; Johnson, Ari; Orihuela, Claudia; Hackett, Jill; Bazile, Junior; Berman, Leslie; Ballard, Madeleine; Panjabi, Rajesh Ramesh; Ternier, Ralph; Slavin, Samuel Dennis; Lee, Scott; Selinsky, Steve; Mitnick, Carole Diane (Co-Action Publishing, 2013)
      Introduction: Despite decades of experience with community health workers (CHWs) in a wide variety of global health projects, there is no established conceptual framework that structures how implementers and researchers ...

    • Acquired and Transmitted Multidrug Resistant Tuberculosis: The Role of Social Determinants 

      Odone, Anna; Calderon, Roger; Becerra, Mercedes C.; Zhang, Zibiao; Contreras, Carmen C.; Yataco, Rosa; Galea, Jerome; Lecca, Leonid; Bonds, Matthew H.; Mitnick, Carole D.; Murray, Megan B. (Public Library of Science, 2016)
      Although risk factors for multi-drug resistant tuberculosis are known, few studies have differentiated between acquired and transmitted resistance. It is important to identify factors associated with these different ...

    • Aggressive Regimens for Multidrug-Resistant Tuberculosis Decrease All-Cause Mortality 

      Mitnick, Carole Diane; Franke, Molly Forrest; Rich, Michael Leonard; Alcantara Viru, Felix A.; Appleton, Sasha C.; Atwood, Sidney S.; Bayona, Jaime N.; Bonilla, Cesar A.; Chalco, Katiuska; Fraser, Hamish S. F.; Furin, Jennifer J.; Guerra, Dalia; Hurtado, Rocio M.; Joseph, Keith; Llaro, Karim; Mestanza, Lorena; Mukherjee, Joia S.; Muñoz, Maribel; Palacios, Eda; Sanchez, Epifanio; Seung, Kwonjune J.; Shin, Sonya S.; Sloutsky, Alexander; Tolman, Arielle W.; Becerra, Mercedes C. (Public Library of Science, 2013)
      Rationale: A better understanding of the composition of optimal treatment regimens for multidrug-resistant tuberculosis (MDR-TB) is essential for expanding universal access to effective treatment and for developing new ...

    • Evaluation of high-dose rifampin in patients with new, smear-positive tuberculosis (HIRIF): study protocol for a randomized controlled trial 

      Milstein, Meredith; Lecca, Leonid; Peloquin, Charles; Mitchison, Denis; Seung, Kwonjune; Pagano, Marcello; Coleman, David; Osso, Elna; Coit, Julia; Vargas Vasquez, Dante Elmo; Sanchez Garavito, Epifanio; Calderon, Roger; Contreras, Carmen; Davies, Geraint; Mitnick, Carole D. (BioMed Central, 2016)
      Background: Evidence has existed for decades that higher doses of rifampin may be more effective, but potentially more toxic, than standard doses used in tuberculosis treatment. Whether increased doses of rifampin could ...

    • Issues in design and interpretation of MDR-TB clinical trials: report of the first Global MDR-TB Clinical Trials Landscape Meeting 

      Mitnick, Carole D; Rusen, ID; Bain, Lisa J; Horsburgh, C Robert (BioMed Central, 2015)
      Recognizing that the current MDR-TB regimen is suboptimal and based on low-quality evidence, the Global MDR-TB Clinical Trials Landscape Meeting was held in December, 2014 to strategize about coordination of research and ...

    • Long-term Follow-up for Multidrug-Resistant Tuberculosis 

      Shin, Sonya Sunhi; Furin, Jennifer J.; Alcántara, Felix; Bayona, Jaime; Sánchez, Epifanio; Mitnick, Carole Diane (Centers for Disease Control and Prevention, 2006)
      Patients treated in Peru for multidrug-resistant tuberculosis (MDR-TB) were followed-up for a median of 67 months. Among 86 patients considered cured after completion of treatment, 97% remain healthy; 1 patient relapsed. ...

    • Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible 

      Bonilla, Cesar A.; Crossa, Aldo; Jave, Hector O.; Jamanca, Ronal B.; Herrera, Cesar; Asencios, Luis; Mendoza, Alberto; Zignol, Matteo; Jaramillo, Ernesto; Mitnick, Carole Diane; Bayona, Jaime (Public Library of Science, 2008)
      Aim: To describe the incidence of extensive drug-resistant tuberculosis (XDR-TB) reported in the Peruvian National multidrug-resistant tuberculosis (MDR-TB) registry over a period of more than ten years and present the ...

    • Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients 

      Ahuja, Shama D.; Ashkin, David; Avendano, Monika; Banerjee, Rita; Bauer, Melissa; Bayona, Jamie N.; Becerra, Mercedes C.; Benedetti, Andrea; Burgos, Marcos; Centis, Rosella; Chan, Eward D.; Chiang, Chen-Yuan; Cox, Helen; D'Ambrosio, Lia; DeRiemer, Kathy; Dung, Nguyen Huy; Enarson, Donald; Falzon, Dennis; Flanagan, Katherine; Flood, Jennifer; Garcia-Garcia, Maria L.; Gandhi, Neel; Granich, Reuben M.; Hollm-Delgado, Maria G.; Holtz, Timothy H.; Iseman, Michael D.; Jarlsberg, Leah G.; Keshavjee, Salmaan A.; Kim, Hye-Ryoun; Koh, Won-Jung; Lancaster, Joey; Lange, Christophe; de Lange, Wiel C. M.; Leimane, Vaira; Leung, Chi Chiu; Li, Jiehui; Menzies, Dick; Migliori, Giovanni B.; Mishustin, Sergey P.; Mitnick, Carole Diane; Narita, Masa; O'Riordan, Philly; Pai, Madhukar; Palmero, Domingo; Park, Seung-kyu; Pasvol, Geoffrey; Peña, Jose; Pérez-Guzmán, Carlos; Quelapio, Maria I. D.; Ponce-de-Leon, Alfredo; Riekstina, Vija; Robert, Jerome; Royce, Sarah; Schaaf, H. Simon; Seung, Kwonjune Justin; Shah, Lena; Shim, Tae Sun; Shin, Sonya Sunhi; Shiraishi, Yuji; Sifuentes-Osornio, José; Sotgiu, Giovanni; Strand, Matthew J.; Tabarsi, Payam; Tupasi, Thelma E.; van Altena, Robert; Van der Walt, Martie; Van der Werf, Tjip S.; Vargas, Mario H.; Viiklepp, Pirett; Westenhouse, Janice; Yew, Wing Wai; Yim, Jae-Joon (Public Library of Science, 2012)
      Background: Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of ...

    • Multidrug-Resistant Tuberculosis Management in Resource-Limited Settings 

      Nathanson, Eva; Lambregts-van Weezenbeek, Catharina; Gupta, Rajesh; Blöndal, Kai; Caminero, José A.; Cegielski, J. Peter; Danilovits, Manfred; Espinal, Marcos A.; Hollo, Vahur; Jaramillo, Ernesto; Leimane, Vaira; Nunn, Paul; Pasechnikov, Alexander; Tupasi, Thelma; Wells, Charles; Raviglione, Mario C.; Rich, Michael Leonard; Bayona, Jaime; Mitnick, Carole Diane; Mukherjee, Joia Stapleton (Centers for Disease Control and Prevention, 2006)
      Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: ...

    • Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method 

      Mitnick, Carole D.; White, Richard A.; Lu, Chunling; Rodriguez, Carly A.; Bayona, Jaime; Becerra, Mercedes C.; Burgos, Marcos; Centis, Rosella; Cohen, Theodore; Cox, Helen; D'Ambrosio, Lia; Danilovitz, Manfred; Falzon, Dennis; Gelmanova, Irina Y.; Gler, Maria T.; Grinsdale, Jennifer A.; Holtz, Timothy H.; Keshavjee, Salmaan; Leimane, Vaira; Menzies, Dick; Migliori, Giovanni Battista; Milstein, Meredith B.; Mishustin, Sergey P.; Pagano, Marcello; Quelapio, Maria I.; Shean, Karen; Shin, Sonya S.; Tolman, Arielle W.; van der Walt, Martha L.; Van Deun, Armand; Viiklepp, Piret (European Respiratory Society, 2016)
      Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of ...

    • The need to accelerate access to new drugs for multidrug-resistant tuberculosis 

      Cox, Helen S; Furin, Jennifer J; Mitnick, Carole D; Daniels, Colleen; Cox, Vivian; Goemaere, Eric (World Health Organization, 2015)
      Abstract Approximately half a million people are thought to develop multidrug-resistant tuberculosis annually. Barely 20% of these people currently receive recommended treatment and only about 10% are successfully treated. ...

    • Programmatic Management of Drug-Resistant Tuberculosis: An Updated Research Agenda 

      Mitnick, Carole D.; Rodriguez, Carly A.; Hatton, Marita L.; Brigden, Grania; Cobelens, Frank; Grobusch, Martin P.; Horsburgh, Robert; Lange, Christoph; Lienhardt, Christian; Oren, Eyal; Podewils, Laura J.; Seaworth, Barbara; van den Hof, Susan; Daley, Charles L.; Gebhard, Agnes C.; Wares, Fraser (Public Library of Science, 2016)
      Introduction: There are numerous challenges in delivering appropriate treatment for multidrug-resistant tuberculosis (MDR-TB) and the evidence base to guide those practices remains limited. We present the third updated ...

    • Propensity Score-Based Approaches to Confounding by Indication in Individual Patient Data Meta-Analysis: Non-Standardized Treatment for Multidrug Resistant Tuberculosis 

      Fox, Gregory J.; Benedetti, Andrea; Mitnick, Carole D.; Pai, Madhukar; Menzies, Dick (Public Library of Science, 2016)
      Background: In the absence of randomized clinical trials, meta-analysis of individual patient data (IPD) from observational studies may provide the most accurate effect estimates for an intervention. However, confounding ...

    • A Systematic Review of Reported Cost for Smear and Culture Tests during Multidrug-Resistant Tuberculosis Treatment 

      Lu, Chunling; Liu, Qingsong; Sarma, Aartik Ananthsai; Fitzpatrick, Christopher; Falzon, Dennis; Mitnick, Carole Diane (Public Library of Science, 2013)
      Background: In 2011, World Health Organization revised its recommendation for microbiological monitoring during treatment for multidrug-resistant tuberculosis (MDR-TB) by increasing the frequency of culture examination ...

    • Time to Culture Conversion and Regimen Composition in Multidrug-Resistant Tuberculosis Treatment 

      Tierney, Dylan B.; Franke, Molly F.; Becerra, Mercedes C.; Alcántara Virú, Félix A.; Bonilla, César A.; Sánchez, Epifanio; Guerra, Dalia; Muñoz, Maribel; Llaro, Karim; Palacios, Eda; Mestanza, Lorena; Hurtado, Rocío M.; Furin, Jennifer J.; Shin, Sonya; Mitnick, Carole D. (Public Library of Science, 2014)
      Sputum cultures are an important tool in monitoring the response to tuberculosis treatment, especially in multidrug-resistant tuberculosis. There has, however, been little study of the effect of treatment regimen composition ...

    • Treatment Outcomes for Adolescents With Multidrug-Resistant Tuberculosis in Lima, Peru 

      Tierney, Dylan B.; Milstein, Meredith B.; Manjourides, Justin; Furin, Jennifer J.; Mitnick, Carole D. (SAGE Publications, 2016)
      Treatment outcomes for adolescents with multidrug-resistant tuberculosis are rarely reported and, to date, have been poor. Among 90 adolescents from Lima, Peru, 68 (75.6%) achieved cure or completion of treatment. Unsuccessful ...