Browsing by Author "Wang, Changning"
Now showing items 1-6 of 6
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Design, Synthesis, and Evaluation of Hydroxamic Acid-Based Molecular Probes for In Vivo Imaging of Histone Deacetylase (HDAC) in Brain
Hooker, Jacob M; Wang, Changning; Eessalu, Thomas E.; Barth, Vanessa N.; Mitch, Charles H.; Wagner, Florence F.; Hong, Yijia; Neelamegam, Ramesh; Schroeder, Frederick A; Holson, Edward B.; Haggarty, Stephen John (e-Century Publishing, 2014)Hydroxamic acid-based histone deacetylase inhibitors (HDACis) are a class of molecules with therapeutic potential currently reflected in the use of suberoylanilide hydroxamic acid (SAHA; Vorinostat) to treat cutaneous ... -
Evaluation of Potential PET Imaging Probes for the Orexin 2 Receptors
Wang, Changning; Wilson, Colin M.; Moseley, Christian K.; Carlin, Stephen M.; Hsu, Shirley; Arabasz, Grae; Schroeder, Frederick A; Sander, Christin Y.; Hooker, Jacob M (Elsevier BV, 2013)A wide range of central nervous system (CNS) disorders, particularly those related to sleep, are associated with the abnormal function of orexin (OX) receptors. Several orexin receptor antagonists have been reported in ... -
Imaging Evaluation of 5HT\(_{2C}\) Agonists, [\(^{11}\)C]WAY-163909 and [\(^{11}\)C]Vabicaserin, Formed by Pictet–Spengler Cyclization
Neelamegam, Ramesh; Hellenbrand, Tim; Schroeder, Frederick A; Wang, Changning; Hooker, Jacob M (American Chemical Society (ACS), 2014)The serotonin subtype 2C (5HT\(_{2C}\)) receptor is an emerging and promising drug target to treat several disorders of the human central nervous system. In this current report, two potent and selective 5HT\(_{2C}\) full ... -
In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs
Wang, Changning; Schroeder, Frederick A.; Wey, Hsiao-Ying; Borra, Ronald; Wagner, Florence F.; Reis, Surya; Kim, Sung Won; Holson, Edward B.; Haggarty, Stephen J.; Hooker, Jacob M. (American Chemical Society, 2014)Epigenetic enzymes are now targeted to treat the underlying gene expression dysregulation that contribute to disease pathogenesis. Histone deacetylases (HDACs) have shown broad potential in treatments against cancer and ... -
Radiosynthesis and Evaluation of [11C]EMPA as a Potential PET Tracer for Orexin 2 Receptors
Wang, Changning; Moseley, Christian K.; Carlin, Stephen M.; Wilson, Colin M.; Neelamegam, Ramesh; Hooker, Jacob M (Elsevier BV, 2013)EMPA is a selective antagonist of orexin 2 (OX2) receptors. Previous literature with [3H]-EMPA suggest that it may be used as an imaging agent for OX2 receptors; however, brain penetration is known to be modest. To evaluate ... -
Visualizing Epigenetics: Current Advances and Advantages in HDAC PET Imaging Techniques
Wang, Changning; Schroeder, Frederick A; Hooker, Jacob M (Elsevier BV, 2014)Abnormal gene regulation as a consequence of flawed epigenetic mechanisms may be central to the initiation and persistence of many human diseases. However, the association of epigenetic dysfunction with disease and the ...