Browsing by Author "Bush, A"

Now showing items 1-2 of 2

    • Intracellular Amyloid Formation in Muscle Cells of Aβ-Transgenic Caenorhabditis Elegans: Determinants and Physiological Role in Copper Detoxification 

      Minniti, Alicia N; Rebolledo, Daniela L; Grez, Paula M; Fadic, Ricardo; Aldunate, Rebeca; Volitakis, Irene; Cherny, Robert A; Opazo, Carlos; Masters, Colin; Inestrosa, Nibaldo C; Bush, Ashley Ian (BioMed Central, 2009)
      Background: The amyloid β-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The intrinsic and external/environmental factors that determine ...

    • Mechanisms of Copper Ion Mediated Huntington's Disease Progression 

      Fox, Jonathan H.; Kama, Jibrin A.; Lieberman, Gregory; Chopra, Raman; Dorsey, Kate; Volitakis, Irene; Cherny, Robert A.; Chopra, Vanita; Bush, Ashley Ian; Hersch, Steven M. (Public Library of Science, 2007)
      Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and striatal degeneration. Copper and iron are ...