Browsing by Author "Wester, C"

Now showing items 1-5 of 5

    • Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana 

      Shapiro, R.L.; Hughes, M.D.; Ogwu, Anthony; Kitch, Doug William; Lockman, Shahin; Moffat, C.; Makhema, Joseph Moeketsi; Moyo, S; Thior, Ibou; McIntosh, Kenneth; van Widenfelt, E.; Leidner, Jean A.; Powis, Kathleen Marie; Asmelash, A.; Tumbare, E.; Zwerski, S.; Sharma, Upasna; Handelsman, E.; Mburu, K.; Jayeoba, O.; Moko, E.; Souda, Shashidhar Vaman; Lubega, E.; Akhtar, M.; Wester, C William; Tuomola, R.; Snowden, W.; Martinez-Tristani, M.; Mazhani, L.; Essex, Myron Elmer (New England Journal of Medicine (NEJM/MMS), 2010)
      BACKGROUND: The most effective highly active antiretroviral therapy (HAART) to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) in pregnancy and its efficacy during breast-feeding are ...

    • HIV-1 Subtype C-Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission 

      Baum, Marianna; Thior, Ibou; Asmelash, Aida; Campa, Adriana; van Widenfelt, Erik; Mine, Madisa; Moffat, Claire; Mmalane, Mompati; Gilbert, Peter; Novitsky, Vladimir A.; Wang, Rui; Bussmann, Hermann; Lockman, Shahin; Shapiro, Roger L.; Wester, Carolyn Negley; Wester, C William; Ogwu, Anthony; Musonda, Rosemary Mubanga; Moyo, Sikhulile; Makhema, Joseph Moeketsi; Marlink, Richard George; Seage, George R.; De Gruttola, Victor Gerard; Essex, Myron Elmer (Public Library of Science, 2010)
      The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in Botswana, the median baseline plasma ...

    • Nutrition and Inflammation Serum Biomarkers Are Associated with 12-Week Mortality among Malnourished Adults Initiating Antiretroviral Therapy in Zambia 

      Blevins, Meridith; Nyirenda, Christopher; Zulu, Isaac; Mwango, Albert; Koethe, John R.; Kabagambe, Edmond K.; Shepherd, Bryan E.; Wester, C. William; Chiasera, Janelle M.; Mulenga, Lloyd B.; Heimburger, Douglas C. (BioMed Central, 2011)
      Background: A low body mass index (BMI) at antiretroviral therapy (ART) initiation is a strong predictor of mortality among HIV-infected adults in resource-constrained settings. The relationship between nutrition and ...

    • Risk Factors for Symptomatic Hyperlactatemia and Lactic Acidosis Among Combination Antiretroviral Therapy-Treated Adults in Botswana: Results from a Clinical Trial 

      Wester, C William; Eden, Svetlana K.; Shepherd, Bryan E.; Bussmann, Hermann; Novitsky, Vladimir A.; Samuels, David C.; Hendrickson, Sher L.; Winkler, Cheryl A.; O, Stephen J.; Essex, Myron Elmer; D, Richard T.; De Gruttola, Victor Gerard; Marlink, Richard G. (Mary Ann Liebert Inc., 2012)
      Nucleoside analogue reverse transcriptase inhibitors are an integral component of combination antiretroviral treatment regimens. However, their ability to inhibit polymerase-γ has been associated with several mitochondrial ...

    • Virologic, Immunologic and Clinical Responses in Foreign-Born versus US-Born HIV-1 Infected Adults Initiating Antiretroviral Therapy: An Observational Cohort Study 

      Parrish, Deidra D.; Blevins, Meridith; Stinnette, Samuel E.; Rebeiro, Peter F.; Shepherd, Bryan E.; Sterling, Timothy R.; McGowan, Catherine C.; Wester, C William (Public Library of Science, 2012)
      Introduction: Mortality rates within the first year of combination antiretroviral therapy (cART) initiation are several-fold higher in resource-limited countries than in resource-replete settings. However studies in western ...