Now showing items 1-9 of 9

    • Amygdala Perfusion Is Predicted by Its Functional Connectivity with the Ventromedial Prefrontal Cortex and Negative Affect 

      Coombs III, Garth; Loggia, Marco L.; Greve, Douglas N.; Holt, Daphne J. (Public Library of Science, 2014)
      Background: Previous studies have shown that the activity of the amygdala is elevated in people experiencing clinical and subclinical levels of anxiety and depression (negative affect). It has been proposed that a reduction ...
    • Asymmetric projections of the arcuate fasciculus to the temporal cortex underlie lateralized language function in the human brain 

      Takaya, Shigetoshi; Kuperberg, Gina R.; Liu, Hesheng; Greve, Douglas N.; Makris, Nikos; Stufflebeam, Steven M. (Frontiers Media S.A., 2015)
      The arcuate fasciculus (AF) in the human brain has asymmetric structural properties. However, the topographic organization of the asymmetric AF projections to the cortex and its relevance to cortical function remain unclear. ...
    • Automated MRI Measures Identify Individuals with Mild Cognitive Impairment and Alzheimer's Disease 

      Desikan, Rahul S.; Cabral, Howard J.; Hess, Christopher P.; Dillon, William P.; Glastonbury, Christine M.; Weiner, Michael W.; Schmansky, Nicholas J.; Salat, David H.; Greve, Douglas N.; Buckner, Randy Lee; Fischl, Bruce R.; Alzheimer’s Disease Neuroimaging Initiative (Oxford University Press, 2009)
      Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic ...
    • The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals 

      Dickerson, Bradford Clark; Bakkour, Akram; Salat, David H.; Feczko, Eric; Pacheco, Jenni; Greve, Douglas N.; Grodstein, Francine; Wright, Christopher Ian; Blacker, Deborah Lynne; Rosas, Herminia Diana; Sperling, Reisa Anne; Atri, Alireza; Growdon, John Herbert; Hyman, Bradley Theodore; Morris, John C.; Fischl, Bruce R.; Buckner, Randy Lee (Oxford University Press, 2009)
      Alzheimer's disease (AD) is associated with neurodegeneration in vulnerable limbic and heteromodal regions of the cerebral cortex, detectable in vivo using magnetic resonance imaging. It is not clear whether abnormalities ...
    • Dopamine D1 signaling organizes network dynamics underlying working memory 

      Roffman, Joshua L.; Tanner, Alexandra S.; Eryilmaz, Hamdi; Rodriguez-Thompson, Anais; Silverstein, Noah J.; Ho, New Fei; Nitenson, Adam Z.; Chonde, Daniel B.; Greve, Douglas N.; Abi-Dargham, Anissa; Buckner, Randy L.; Manoach, Dara S.; Rosen, Bruce R.; Hooker, Jacob M.; Catana, Ciprian (American Association for the Advancement of Science, 2016)
      Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined ...
    • Mindfulness-Based Stress Reduction, Fear Conditioning, and The Uncinate Fasciculus: A Pilot Study 

      Hölzel, Britta K.; Brunsch, Vincent; Gard, Tim; Greve, Douglas N.; Koch, Kathrin; Sorg, Christian; Lazar, Sara W.; Milad, Mohammed R. (Frontiers Media S.A., 2016)
      Mindfulness has been suggested to impact emotional learning, but research on these processes is scarce. The classical fear conditioning/extinction/extinction retention paradigm is a well-known method for assessing emotional ...
    • Neuronal Dysfunction and Disconnection of Cortical Hubs in Non-Demented Subjects with Elevated Amyloid Burden 

      Drzezga, Alexander; Sreenivasan, Aishwarya; Talukdar, Tanveer; Sullivan, Caroline; Sepulcre, Jorge; Putcha, Deepti; Becker, John Alex; van Dijk, Koene R A; Greve, Douglas N.; Johnson, Keith Alan; Sperling, Reisa Anne; Schultz, Aaron (Oxford University Press, 2011)
      Disruption of functional connectivity between brain regions may represent an early functional consequence of b-amyloid pathology prior to clinical Alzheimer’s disease. We aimed to investigate if non-demented older individuals ...
    • A Phenotype of Early Infancy Predicts Reactivity of the Amygdala in Male Adults 

      Schwartz, C. E.; Kunwar, P. S.; Greve, Douglas N.; Kagan, Jerome; Snidman, Nancy Claire; Bloch, R. B. (Nature Publishing Group, 2011)
      One of the central questions that has occupied those disciplines concerned with human development is the nature of continuities and discontinuities from birth to maturity. The amygdala plays a central role in the processing ...
    • Regional White Matter Volume Differences in Nondemented Aging and Alzheimer's Disease 

      Salat, David; Greve, Douglas; Pacheco, Jennifer; Quinn, Brian T.; Helmer, Karl; Buckner, Randy; Fischl, Bruce (Elsevier, 2009)
      Accumulating evidence suggests that altered cerebral white matter (WM) influences normal aging, and further that WM degeneration may modulate the clinical expression of Alzheimer's disease (AD). Here we conducted a study ...