Browsing by Author "Januzzi, James"

Now showing items 1-11 of 11

    • Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab 

      Sawaya, H.; Sebag, I. A.; Plana, J. C.; Januzzi, James Louis; Ky, B.; Tan, T. C.; Cohen, V.; Banchs, J.; Carver, J. R.; Wiegers, S. E.; Martin, R. P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, E; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Ovid Technologies (Wolters Kluwer Health), 2012)
      Background: Because cancer patients survive longer, the impact of cardiotoxicity associated with the use of cancer treatments escalates. The present study investigates whether early alterations of myocardial strain and ...

    • Association of Novel Biomarkers of Cardiovascular Stress With Left Ventricular Hypertrophy and Dysfunction: Implications for Screening 

      Xanthakis, Vanessa; Larson, Martin G.; Wollert, Kai C.; Aragam, Jayashri; Cheng, Susan; Ho, Jennifer; Coglianese, Erin; Levy, Daniel; Colucci, Wilson S.; Michael Felker, G.; Benjamin, Emelia J.; Januzzi, James L.; Wang, Thomas J.; Vasan, Ramachandran S. (Blackwell Publishing Ltd, 2013)
      Background: Currently available screening tools for left ventricular (LV) hypertrophy (LVH) and systolic dysfunction (LVSD) are either expensive (echocardiography) or perform suboptimally (B‐type natriuretic peptide [BNP]). ...

    • Common Genetic Variation at the IL1RL1 Locus Regulates IL-33/ST2 Signaling 

      Ho, Jennifer E.; Chen, Wei-Yu; Chen, Ming-Huei; Larson, Martin G.; McCabe, Elizabeth L.; Cheng, Susan; Ghorbani, Anahita; Coglianese, Erin; Emilsson, Valur; Johnson, Andrew D.; Walter, Stefan; Franceschini, Nora; O'Donnell, Christopher Joseph; Dehghan, Abbas; Lu, Chen; Levy, Daniel; Newton-Cheh, Christopher Holmes; Lin, Honghuang; Felix, Janine F.; Schreiter, Eric R.; Vasan, Ramachandran S.; Januzzi, James Louis; Lee, Richard Theodore; Wang, Thomas (American Society for Clinical Investigation, 2013)
      The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response ...

    • Depression and Cardiac Disease: Epidemiology, Mechanisms, and Diagnosis 

      Huffman, Jeffery C.; Celano, Christopher Michael; Beach, Scott; Motiwala, Shweta Rajeev; Januzzi, James Louis (Hindawi Publishing Corporation, 2013)
      In patients with cardiovascular disease (CVD), depression is common, persistent, and associated with worse health-related quality of life, recurrent cardiac events, and mortality. Both physiological and behavioral ...

    • Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients 

      Sawaya, Heloisa; Sebag, Igal A.; Plana, Juan Carlos; Januzzi, James Louis; Ky, Bonnie; Cohen, Victor; Gosavi, Sucheta; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2011)
      As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction ...

    • Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab 

      Ky, Bonnie; Putt, Mary; Sawaya, Heloisa; French, Benjamin; Januzzi, James Louis; Sebag, Igal A.; Plana, Juan Carlos; Cohen, Victor; Banchs, Jose; Carver, Joseph R.; Wiegers, Susan E.; Martin, Randolph P.; Picard, Michael Howard; Gerszten, Robert Edgardo; Halpern, Elkan; Passeri, Jonathan James; Kuter, Irene; Scherrer-Crosbie, Marielle (Elsevier BV, 2014)
      Objectives: The aim of this study was to determine if individual or multiple biomarkers are associated with cardiotoxicity in patients with breast cancer undergoing cancer therapy. Background: Current methods to identify ...

    • Evidence of Uncoupling between Renal Dysfunction and Injury in Cardiorenal Syndrome: Insights from the BIONICS Study 

      Legrand, Matthieu; De Berardinis, Benedetta; Gaggin, Hanna K.; Magrini, Laura; Belcher, Arianna; Zancla, Benedetta; Femia, Alexandra; Simon, Mandy; Motiwala, Shweta; Sambhare, Rasika; Di Somma, Salvatore; Mebazaa, Alexandre; Vaidya, Vishal S.; Januzzi, James L.; (GREAT), from the Global Research on Acute Conditions Team (Public Library of Science, 2014)
      Objective: The objective of the study was to assess urinary biomarkers of renal injury for their individual or collective ability to predict Worsening renal function (WRF) in patients with acutely decompensated heart failure ...

    • Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab 

      Putt, M.; Hahn, V. S.; Januzzi, James Louis; Sawaya, H.; Sebag, I. A.; Plana, J. C.; Picard, Michael Howard; Carver, J. R.; Halpern, E; Kuter, Irene; Passeri, Jonathan James; Cohen, V.; Banchs, J.; Martin, R. P.; Gerszten, Robert Edgardo; Scherrer-Crosbie, Marielle; Ky, B. (American Association for Clinical Chemistry (AACC), 2015)
      BACKGROUND: Biomarkers may play an important role in identifying patients at risk for cancer therapy cardiotoxicity. Our objectives were to define the patterns of change in biomarkers with cancer therapy and their associations ...

    • Prognostic Significance of Elevated Cardiac Troponin-T Levels in Acute Respiratory Distress Syndrome Patients 

      Rivara, Matthew B.; Bajwa, Ednan Khalid; Januzzi, James Louis; Gong, Michelle Ng; Thompson, B. Taylor; Christiani, David C. (Public Library of Science, 2012)
      Background: Elevated levels of biochemical markers of myocardial necrosis have been associated with worsened outcomes in Acute Respiratory Distress Syndrome (ARDS), but there are few prospective data on this relationship. ...

    • The prosurvival protein BAG3: a new participant in vascular homeostasis 

      Carrizzo, Albino; Damato, Antonio; Ambrosio, Mariateresa; Falco, Antonia; Rosati, Alessandra; Capunzo, Mario; Madonna, Michele; Turco, Maria C; Januzzi, James L; De Laurenzi, Vincenzo; Vecchione, Carmine (Nature Publishing Group, 2016)
      Bcl2-associated athanogene 3 (BAG3), is constitutively expressed in a few normal cell types, including myocytes, peripheral nerves and in the brain, and is also expressed in certain tumors. To date, the main studies about ...

    • Usefulness of Combining Galectin-3 and BIVA Assessments in Predicting Short- and Long-Term Events in Patients Admitted for Acute Heart Failure 

      De Berardinis, Benedetta; Magrini, Laura; Zampini, Giorgio; Zancla, Benedetta; Salerno, Gerardo; Cardelli, Patrizia; Di Stasio, Enrico; Gaggin, Hanna K.; Belcher, Arianna; Parry, Blair A.; Nagurney, John T.; Januzzi, James L.; Di Somma, Salvatore (Hindawi Publishing Corporation, 2014)
      Introduction:. Acute heart failure (AHF) is associated with a higher risk for the occurrence of rehospitalization and death. Galectin-3 (GAL3) is elevated in AHF patients and is an indicator in predicting short-term ...