Browsing by Author "Platzer, Barbara"

Now showing items 1-4 of 4

    • Antigen Cross-Presentation of Immune Complexes 

      Platzer, Barbara; Stout, Madeleine; Fiebiger, Edda (Frontiers Media S.A., 2014)
      The ability of dendritic cells (DCs) to cross-present tumor antigens has long been a focus of interest to physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A ...

    • Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites 

      Platzer, Barbara; Baker, Kristi; Vera, Miguel Pinilla; Singer, Kathleen; Panduro, Marisella; Lexmond, Willem S.; Turner, Devin; Vargas, Sara O.; Kinet, Jean-Pierre; Maurer, Dieter; Baron, Rebecca M.; Blumberg, Richard S.; Fiebiger, Edda (2014)
      Antigen-mediated crosslinking of Immunoglobulin E (IgE) bound to mast cells/basophils via FcεRI, the high affinity IgE Fc-receptor, is a well-known trigger of allergy. In humans, but not mice, dendritic cells (DCs) also ...

    • A single glycan on IgE is indispensable for initiation of anaphylaxis 

      Shade, Kai-Ting C.; Platzer, Barbara; Washburn, Nathaniel; Mani, Vinidhra; Bartsch, Yannic C.; Conroy, Michelle; Pagan, Jose D.; Bosques, Carlos; Mempel, Thorsten R.; Fiebiger, Edda; Anthony, Robert M. (The Rockefeller University Press, 2015)
      Immunoglobulin ε (IgE) antibodies are the primary mediators of allergic diseases, which affect more than 1 in 10 individuals worldwide. IgE specific for innocuous environmental antigens, or allergens, binds and sensitizes ...

    • A Soluble Form of the High Affinity IgE Receptor, Fc-Epsilon-RI, Circulates in Human Serum 

      Dehlink, Eleonora; Platzer, Barbara; Baker, Alexandra H.; LaRosa, Jessica; Pardo, Michael; Dwyer, Peter; Yen, Elizabeth Hechavarria; Szepfalusi, Zsolt; Nurko, Samuel; Fiebiger, Edda (Public Library of Science, 2011)
      Soluble IgE receptors are potential in vivo modulators of IgE-mediated immune responses and are thus important for our basic understanding of allergic responses. We here characterize a novel soluble version of the IgE-binding ...