Browsing by Author "Bergman, Jack"

Now showing items 1-2 of 2

    • Probing the Carboxyester Side Chain in Controlled Deactivation (−)-Δ8-Tetrahydrocannabinols 

      Nikas, Spyros P.; Sharma, Rishi; Paronis, Carol A.; Kulkarni, Shashank; Thakur, Ganesh A.; Hurst, Dow; Wood, JodiAnne T.; Gifford, Roger S.; Rajarshi, Girija; Liu, Yingpeng; Raghav, Jimit Girish; Guo, Jason Jianxin; Järbe, Torbjörn U.C.; Reggio, Patricia H.; Bergman, Jack; Makriyannis, Alexandros (American Chemical Society, 2014)
      We recently reported on a controlled deactivation/detoxification approach for obtaining cannabinoids with improved druggability. Our design incorporates a metabolically labile ester group at strategic positions within the ...

    • Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid 

      Justinova, Zuzana; Mascia, Paola; Wu, Hui-Qiu; Secci, Maria E.; Redhi, Godfrey H.; Panlilio, Leigh V.; Scherma, Maria; Barnes, Chanel; Parashos, Alexandra; Zara, Tamara; Fratta, Walter; Solinas, Marcello; Pistis, Marco; Bergman, Jack; Kangas, Brian D.; Ferré, Sergi; Tanda, Gianluigi; Schwarcz, Robert; Goldberg, Steven R. (2013)
      In the reward circuitry of the brain, alpha-7-nicotinic acetylcholine receptors (α7nAChRs) modulate effects of delta-9-tetrahydrocannabinol (THC), marijuana’s main psychoactive ingredient. Kynurenic acid (KYNA) is an ...