Browsing by Author "Houseman, Eugene Andres"

Now showing items 1-6 of 6

    • Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context 

      Christensen, Brock C.; Marsit, Carmen J.; Zheng, Shichun; Wrensch, Margaret R.; Wiemels, Joseph L.; Nelson, Heather H.; Karagas, Margaret R.; Padbury, James F.; Yeh, Ru-Fang; Wiencke, John K.; Kelsey, Karl T.; Houseman, Eugene Andres; Bueno, Raphael; Sugarbaker, David John (Public Library of Science, 2009)
      Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human ...

    • Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Marsit, Carmen J.; Houseman, Eugene Andres; Lopez-Fagundo, Cristina Y.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Nelson, Heather H.; Kelsey, Karl T. (Oxford University Press, 2008)
      Malignant pleural mesothelioma (MPM) is a rapidly fatal tumor with increasing incidence worldwide responsible for many thousands of deaths annually. Although there is a clear link between exposure to asbestos and mesothelioma, ...

    • Breast Cancer DNA Methylation Profiles Are Associated with Tumor Size and Alcohol and Folate Intake 

      Christensen, Brock C.; Kelsey, Karl T.; Zheng, Shichun; Marsit, Carmen J.; Wrensch, Margaret R.; Wiemels, Joseph L.; Nelson, Heather H.; Karagas, Margaret R.; Kushi, Lawrence H.; Kwan, Marilyn L.; Wiencke, John K.; Horwitz, Marshall S.; Houseman, Eugene Andres (Public Library of Science, 2010)
      Although tumor size and lymph node involvement are the current cornerstones of breast cancer prognosis, they have not been extensively explored in relation to tumor methylation attributes in conjunction with other tumor ...

    • Genetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted 

      Poage, Graham M.; Christensen, Brock C.; McClean, Michael D.; Wiencke, John K.; Posner, Marshall R.; Nelson, Heather H.; Marsit, Carmen J.; Kelsey, Karl T.; Hoheisel, Jörg; Houseman, Eugene Andres; Clark, John Ross (Public Library of Science, 2010)
      Background: Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Little work has been done that simultaneously ...

    • The Impact of Diet and Betel Nut Use on Skin Lesions Associated with Drinking-Water Arsenic in Pabna, Bangladesh 

      McCarty, Kathleen M.; Houseman, Eugene Andres; Quamruzzaman, Quazi; Rahman, Mahmuder; Mahiuddin, Golam; Smith, Thomas J.; Ryan, Louise Marie; Christiani, David C. (National Institute of Environmental Health Sciences, 2005)
      An established exposure–response relationship exists between water arsenic levels and skin lesions. Results of previous studies with limited historical exposure data, and laboratory animal studies suggest that diet may ...

    • Model-based Clustering of DNA Methylation Array Data: A Recursive-Partitioning Algorithm for High-dimensional Data Arising as a Mixture of Beta Distributions 

      Christensen, Brock C; Yeh, Ru-Fang; Marsit, Carmen J; Karagas, Margaret R; Wrensch, Margaret; Nelson, Heather H; Wiemels, Joseph; Zheng, Shichun; Wiencke, John K; Kelsey, Karl T; Houseman, Eugene Andres (BioMed Central, 2008)
      Background: Epigenetics is the study of heritable changes in gene function that cannot be explained by changes in DNA sequence. One of the most commonly studied epigenetic alterations is cytosine methylation, which is a ...